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Product Name: Monoammonium Glycyrrhizinate
Chemical Formula: C42H65NO16
CAS Number: 53956-04-0
Supplier: Contact your company’s chemical safety department
Intended Use: Food additive, pharmaceutical intermediate, flavoring agent
Synonyms: Glycyrrhizic acid, ammonium salt, Monoammonium salt of glycyrrhizic acid
Contact Information: Details for immediate safety concerns or spills should go to your workplace safety officer or listed chemical supplier hotline
Emergency Number: Use the country-specific Poison Help Hotline or emergency response number for chemical exposure
GHS Classification: Not classified as hazardous per OSHA Hazard Communication Standard
Hazard Pictograms: No standard pictograms required
Signal Word: None
Hazard Statements: Dust may irritate eyes, skin, or respiratory tract; ingestion of large amounts could cause gastrointestinal upset
Precautionary Statements: Avoid dust formation, prevent contact with eyes, skin, and clothing, use with adequate ventilation
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Potential Health Effects: Eye irritation, mild respiratory discomfort, nausea if swallowed in considerable quantity; rare allergy reports
Environmental Effects: Low risk, but large spills may disrupt aquatic habitats in confined spaces
Chemical Name: Monoammonium Glycyrrhizinate
Purity: >98% typical for pharmaceutical and food grade
Other Ingredients: In high-purity supplies, contaminant levels usually below reporting limits; may contain trace water or residual process reagents depending on vendor
Impurities: Typically not present above standard detection limits for regulated chemical use
Molecular Weight: 837.95 g/mol
Eye Contact: Immediately flush with gentle running water for at least 15 minutes, lift eyelids, remove contact lenses; seek medical attention for persistent irritation
Skin Contact: Remove contaminated clothing and wash skin with soap and plenty of water; medical attention for skin irritation that does not resolve
Inhalation: Move to fresh air, rest, monitor for breathing difficulty; get medical attention if breathing problems or persistent coughing develop
Ingestion: Rinse mouth with water, give water to dilute if person is conscious; do not induce vomiting unless directed; medical attention recommended for significant quantities
Symptoms: Dryness, irritation, possible mild gastrointestinal upset, sneezing or coughing from dust exposure
Flammability: Not highly flammable, powder may pose minor dust explosion risk in enclosed areas
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: Direct water jet on burning powder clouds
Special Hazards: Combustion can yield carbon oxides, ammonia, nitrogen oxides, possible unidentified toxic fumes
Protective Equipment for Firefighters: Self-contained breathing apparatus and protective clothing recommended
Firefighting Precautions: Move containers from area if safe; avoid inhaling any combustion products; keep upwind if possible
Personal Precautions: Ventilate area, avoid breathing dust, wear protective gloves and goggles
Spill Response: Sweep or vacuum up to avoid generating dust; collect material in appropriate container for disposal; wipe area with damp cloth to eliminate residues
Environmental Precautions: Prevent entry into drains or water supplies; notify environmental authorities if a release could impact waterways
Emergency Procedures: Limit access to area, use proper PPE, remove ignition sources if powder forms clouds
Handling: Keep containers tightly sealed; use only in well-ventilated areas; avoid dust generation by handling carefully; practice good hygiene to prevent accidental ingestion
Storage: Store in original containers, dry cool and well-ventilated space, away from direct sunlight or heat sources, separate from incompatible chemicals like strong oxidizers and acids
Storage Conditions: 15-25°C recommended, humidity under 60% to prevent caking or degradation
Specific Uses: Food ingredient, pharmaceutical raw material, or laboratory reagent; keep stored per local regulations for food-grade or pharma ingredients
Exposure Limits: No established occupational exposure limits; minimize dust inhalation
Engineering Controls: Use local exhaust or general room ventilation
Personal Protection: Safety goggles, gloves, lab coat, and dust mask or particulate respirator in high-dust environments
Hygiene Measures: Wash hands after handling, do not eat/drink/smoke in work area
Environmental Controls: Prevent large-scale dust dissemination to air or water
Appearance: White to off-white fine powder
Odor: Faint sweet or characteristic licorice odor
pH: 4.0–5.5 (1% solution in water)
Melting Point/Range: Decomposes without clear melting
Boiling Point: Not applicable
Solubility in Water: Freely soluble
Solubility (Other): Practically insoluble in organic solvents
Vapor Pressure: Not relevant for this substance
Density: 1.28–1.30 g/cm³
Flash Point: Not flammable in standard laboratory conditions
Partition Coefficient: Not measured
Decomposition Temperature: ≥200°C, with breakdown to ammonia and byproducts
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions under normal conditions
Hazardous Reactions: Strong acids may decompose the compound, releasing toxic fumes
Conditions to Avoid: Excessive heat, moisture, strong oxidizing or reducing agents
Incompatible Materials: Strong oxidizers, mineral acids
Hazardous Decomposition Products: Ammonia, carbon monoxide, carbon dioxide, nitrogen oxides, organic residue
Routes of Entry: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Low oral toxicity; no significant acute toxicity data on humans; large doses may cause gastrointestinal symptoms
Skin Irritation: Not usually irritating, may cause dryness to sensitive individuals
Eye Damage/Irritation: Dust may cause mild irritation, redness, watering
Respiratory Sensitization: Not classified as a respiratory sensitizer
Carcinogenicity: Not listed as a carcinogen
Reproductive Effects: No evidence of reproductive toxicity at typical occupational exposure
Other Effects: People with licorice allergies might encounter allergies, rarely
LD50 (Oral, Rat): Above 2000 mg/kg, indicating low toxicity
Persistence and Degradability: Expected to biodegrade in the environment
Bioaccumulative Potential: Low, based on molecular structure and water solubility
Mobility in Soil: Freely mobile due to water solubility
Aquatic Toxicity: No significant aquatic toxicity at release concentrations likely outside manufacturing settings
Other Adverse Effects: None expected at low concentrations, avoid large-scale discharge to surface water or soil
Decomposition: Breaks down to simple organic molecules under natural conditions
Disposal Methods: Dispose of in accordance with local, regional and national regulations; incineration in approved facility for large quantities
Small Quantities: Can go in general waste if permitted by local authority, otherwise collected as chemical waste
Container Disposal: Triple rinse, then follow standard solid waste protocols or return to supplier for recycling where programs exist
Avoid: Disposal in municipal sewage systems or natural water bodies
UN Number: Not assigned
Transport Hazard Class: Not regulated as hazardous material
Packing Group: Not required
Proper Shipping Name: Monoammonium Glycyrrhizinate
Marine Pollutant: No
Special Precautions: Avoid breakage of packaging, keep away from moisture during shipping
Labeling: Standard labeling for food or pharmaceutical raw materials
TSCA (US): Listed
EINECS (EU): Listed
Food Additive Approval: Approved under several regulations for flavoring or sweetening agents, always check country-specific standards
OSHA: Not regulated as hazardous
Other Regulations: Adhere to food and pharmaceutical handling rules, workplace exposure guidelines, and safe use regulations in place locally
Warning Labels: None required in food-grade applications, but dust warnings recommended for bulk use environments
