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Name: Molnupiravir
Chemical Name: 4-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-1,2,4-triazol-3-one
Synonyms: EIDD-2801, MK-4482
CAS Number: 2349386-89-4
Formula: C13H19N3O7
Use: Antiviral agent for COVID-19 treatment
Supplier: Refer to packaging for manufacturer identification and emergency contact information.
Classification: Eye irritation (Category 2), Reproductive toxicity (Category 1B)
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, may damage fertility or the unborn child
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Wear protective gloves, clothing, and eye protection. Do not handle until all safety precautions have been read and understood.
Pictograms: Exclamation mark, Health hazard
Main Ingredient: Molnupiravir (≥ 98%)
Impurities: Not expected to be present at hazardous concentrations under typical pharmaceutical-use conditions
Other Components: May contain formulation excipients (consult product label or manufacturer’s safety data), typically non-hazardous at use concentrations.
Inhalation: Move to fresh air. If symptoms develop, get medical attention.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical help if irritation persists.
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes. Remove contact lenses if easy to do. Get medical help.
Ingestion: Rinse mouth with water. Do not induce vomiting unless instructed by a medical professional. Seek medical advice immediately.
Notes for Physicians: Treat symptomatically. Exposure may require monitoring for delayed or systemic effects.
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide.
Unsuitable Media: Direct water jets may spread dust.
Special Hazards: In combustion, toxic fumes (carbon oxides, nitrogen oxides) may form.
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing. Isolate fire area and deny unnecessary entry.
Personal Precautions: Use personal protective equipment including gloves, safety goggles, and lab coat. Avoid dust generation and inhalation.
Environmental Precautions: Prevent further leakage or spillage. Do not allow to enter drains or surface water.
Methods for Cleaning Up: Contain and collect spillage using a vacuum with HEPA filter or damp sweeping. Place in suitable, labeled container for disposal. Ventilate area, wash surfaces with soap and water.
Handling: Handle with care in well-ventilated area, wear suitable personal protective equipment. Wash hands thoroughly after handling. Avoid generation of dust.
Storage: Keep container tightly closed in cool, dry, well-ventilated area. Protect from light and moisture. Segregate from incompatible materials such as oxidizers.
Incompatibilities: Store away from acids, bases, and strong oxidizing agents. Maintain inventory control and limit access to trained personnel.
Exposure Limits: No established occupational exposure limits for molnupiravir. Implement pharmaceutical best practices for low-exposure handling.
Engineering Controls: Work within closed systems or fume hoods. Provide adequate ventilation in processing areas.
Personal Protection: Wear gloves (nitrile recommended), safety goggles, lab coat or impervious clothing. Respiratory protection (N95 or higher) required if risk of inhalation exists.
Hygiene Measures: No food or drink in work area. Wash hands after handling substance, remove contaminated PPE before leaving workspace.
Appearance: White to practically white powder or crystalline solid
Odor: Odorless or slight
Odor Threshold: Not available
pH: Not available
Melting Point: Approximately 164-167 °C
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not available
Solubility: Freely soluble in water
Partition Coefficient (logP): Approximately -0.8
Vapor Pressure: Negligible at room temperature
Density: Not determined
Stability: Stable under recommended storage conditions.
Decomposition: May release toxic gases on heating.
Chemical Stability: Stable under normal conditions, sensitive to moisture and light.
Possible Reactions: May react with strong oxidizers, acids, and bases. Breakdown can produce hazardous fumes.
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides.
Conditions to Avoid: Excessive heat, humidity, exposure to direct sunlight, and contact with incompatible substances.
Polymerization: Not expected to occur under normal conditions.
Acute Toxicity: Information on animal toxicity points to possible mild to moderate systemic effects by oral, dermal, or inhalation exposure.
Chronic Effects: Repeat-dose studies in animals showed potential reproductive and developmental effects.
Routes of Exposure: Inhalation, skin, eyes, ingestion.
Symptoms: Irritation, headache, nausea may occur.
Carcinogenicity: Not classified as carcinogen based on currently available data.
Mutagenicity: May cause genetic changes in vitro; data from in vivo models remain under study.
Reproductive Toxicity: Evidence suggests possible risk to fertility or fetuses.
Target Organs: No conclusive organ-specific toxicity identified in humans to date.
Ecotoxicity: No direct data on aquatic toxicity; careful management is advised due to potential pharmaceutical effects on wildlife.
Persistence/Degradability: Expected to be partially degraded in wastewater treatment, but data remains limited.
Bioaccumulation: Low potential based on chemical structure (logP value).
Mobility in Soil: May exhibit moderate mobility in aqueous environments.
Other Adverse Effects: Release into environment should be minimized; pharmaceuticals in waterways remain a regulatory and public health concern.
Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations. Do not discharge to sewer systems or environment.
Handling of Waste: Use licensed waste disposal contractors. Packages and residues should be treated as hazardous pharmaceutical waste.
Contaminated Packaging: Dispose of as unused material unless thoroughly cleaned.
UN Number: Not regulated for transport under most circumstances as therapeutic products
Transport Hazard Class: None assigned
Packing Group: None
Proper Shipping Name: Not applicable
Special Precautions: Protect from moisture, physical damage, and unauthorized access during transit.
Environmental Hazards: Avoid releases during loading/unloading.
US Regulations: Not listed on major hazardous materials lists (TSCA, OSHA PELs); regulated as a prescription pharmaceutical by FDA.
EU Regulations: Not classified as hazardous per CLP Regulation (EC 1272/2008), subject to EMA medical product authorization.
Other Regulations: Local regulations regarding handling, disposal, and worker protection apply.
Label Elements: Prescription drug labeling requirements apply; special care and training required for handlers and users.
