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Product Name: Minoxidil Sulfate
Chemical Name: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide sulfate salt
CAS Number: 83701-22-8
Synonyms: 2,4-Diamino-6-piperidinopyrimidine 3-oxide sulfate
Recommended Use: Active pharmaceutical ingredient for topical applications
Manufacturer: Details available through supplier
Emergency Contact: Available through local poison control or on-site supervisor
Relevant Identified Uses: Research, manufacturing, pharmaceutical formulation for hair loss treatment
Classification: Eye Irritant Category 2A, Skin Sensitizer Category 1
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause allergic skin reaction
Precautionary Statements: Wear protective gloves and eye protection, avoid breathing dust or powder, wash hands after handling
Physical Hazards: Not classified as flammable, not combustive under normal storage
Health Hazards: Skin and eye contact causes irritation, ingestion or inhalation leads to systemic effects
Environment Hazards: Not expected to pose acute hazard to aquatic life, yet persistent release to watercourse requires reporting
Chemical Identity: Minoxidil Sulfate
Chemical Formula: C9H15N5O · H2SO4
Purity: 98% minimum (pharmaceutical grade)
Impurities: Minor related substances below 1%, inert excipients in formulated products
Concentration: Usually 100% for raw material, lower in diluted pharmaceutical forms
Additives: None present in pure substance, excipients added by end-user
CAS No: 83701-22-8
Inhalation: Move affected person to fresh air, seek medical attention for significant symptoms or difficulty breathing
Skin Contact: Remove contaminated clothing, rinse skin with water, use mild soap if irritation develops
Eye Contact: Rinse with clean running water for 15 minutes, lift eyelids to flush thoroughly, consult physician if irritation persists
Ingestion: Rinse mouth, seek medical advice, do not induce vomiting unless directed by healthcare personnel
Acute Effects: Irritation, redness, headaches with excessive exposure
Delayed Effects: Allergic reaction, dermatitis after repeated exposure
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, or foam
Unsuitable Extinguishing Media: Do not use water jet directly on powder and dust
Fire Hazards: Decomposes under high heat, emitting nitrogen oxides, sulfur oxides, and carbon oxides
Protective Equipment: Full protective gear and self-contained breathing apparatus recommended
Specific Risks: Toxic fumes likely during thermal breakdown
Explosion Data: Not expected to present explosion hazard under normal conditions
Spill Response: Evacuate area, ventilate if indoors, avoid dust formation
Personal Protection: Wear gloves, protective eyewear, lab coat, dust mask or respirator
Containment: Sweep up with non-sparking equipment, place in closed containers for disposal
Cleaning Method: Damp wipe area, avoid raising dust clouds, dispose of rags and debris securely
Environmental Precautions: Prevent release into drains, watercourses, and soil where feasible
Reporting: Notify environmental authorities if large quantities enter waterways
Handling: Avoid direct skin and eye contact, minimize dust generation, use in well-ventilated area
Hygiene Measures: Wash thoroughly after handling, no eating, drinking, or smoking near product
Storage Conditions: Store in cool, dry, lockable area, keep container tightly closed
Incompatible Materials: Strong oxidizers, acids, strong bases may react
Container Recommendations: Use sealed containers, label clearly, protect from direct sunlight and moisture
Temperature Range: Keep at 2-8°C for best stability, avoid heat above 25°C for extended periods
Engineering Controls: Work in fume hood or use localized ventilation, keep airborne dust to minimum
Exposure Limits: No established occupational exposure limits, follow good chemical hygiene practices
Personal Protection: Wear chemical-resistant gloves, safety goggles, lab coat or coverall
Respiratory Protection: Use NIOSH/MSHA-approved particulate respirator if airborne levels approach nuisance threshold
Environmental Protection: Prevent product from entering sewers or water bodies
Physical State: Solid, crystalline powder
Color: White to off-white
Odor: Odorless
Melting Point: Approximately 262°C (decomposes)
Boiling Point: Not applicable (decomposes on melting)
Solubility: Freely soluble in water, slightly soluble in alcohol
pH: Neutral to slight acidity in aqueous solution
Vapor Pressure: Not volatile
Relative Density: About 1.37 g/cm³
Partition Coefficient (log Pow): Not determined for the sulfate form
Flash Point: Not flammable
Evaporation Rate: Not applicable
Chemical Stability: Stable under normal storage and handling conditions
Conditions to Avoid: Exposure to moisture, prolonged heat, and sunlight
Reactive Substances: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition: Nitrogen oxides, sulfur oxides, carbon oxides form during high heat
Polymerization: No hazardous polymerization occurs
Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Toxicity: Oral LD50 (rat) estimated above 1000 mg/kg
Chronic Exposure: May cause skin sensitization and dermatitis, rare systemic reactions
Irritation: Causes substantial eye and moderate skin irritation
Sensitization: Documented risk of allergenic response in susceptible individuals
Mutagenicity: Not reported as mutagenic in standard assays
Carcinogenicity: No evidence in published animal studies
Reproductive Toxicity: Animal data show no adverse reproductive risks at therapeutic levels
Aquatic Toxicity: Limited data indicate low acute hazard to aquatic organisms
Mobility: Water soluble, possible leaching through soil in significant spills
Persistence and Degradability: Not rapidly biodegradable, may persist in treated environments
Bioaccumulation: Low potential for bioaccumulation in aquatic species
Ecotoxicity Thresholds: Detailed testing unavailable, prudent to minimize environmental discharge
Additional Notes: Keep away from streams, lakes, and fields to avoid unnecessary spread
Waste Treatment: Dispose as hazardous chemical waste through approved contractor
Methods of Disposal: Incinerate solids in a chemical waste incinerator with afterburner and scrubber
Contaminated Packaging: Rinse thoroughly before discarding as chemical waste
Special Precautions: Avoid direct landfill disposal, prevent soil and water contamination
Regulatory References: Consult local, regional, national waste management authorities
UN Number: Not classified for transport under ADR, DOT, IATA, IMDG
Proper Shipping Name: Minoxidil Sulfate, Non-hazardous for transport
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Environmental Hazards: Not a marine pollutant
Special Precautions for Transport: Keep in tightly closed, clearly labeled containers, store away from incompatible materials
Inventory Listings: Registered in several chemical and pharmaceutical substance inventories
Labeling: Meets GHS and CLP labeling requirements for hazardous materials
Workplace Controls: Subject to local chemical safety and occupational hazard legislation
Regulatory Status: Approved API in certain regions, restricted to licensed manufacturing or dispensing sites
Community and National Regulations: Subject to chemical safety, REACH, and environmental protection rules in Europe
Other Applicable Laws: Controlled under transport, waste, and occupational health statutes
