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Product Name: Minocycline Hydrochloride
Chemical Formula: C23H27N3O7·HCl
Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline hydrochloride, Minocin
Recommended Use: Pharmaceutical intermediate, active pharmaceutical ingredient
Manufacturer Details: Refer to shipment paperwork for supplier and emergency contact
CAS Number: 13614-98-7
UN Number: Not regulated for transport
Classification: Eye irritant, skin sensitizer, harmful if swallowed
Signal Word: Warning
Hazard Statements: Causes moderate eye irritation, may cause allergic skin reaction, harmful to aquatic life
Pictogram: Exclamation mark (GHS07)
Precautionary Statements: Avoid breathing dust, wash skin after handling, do not eat or drink during use, avoid release to the environment
Chemical Name: Minocycline Hydrochloride
Concentration: >98% (active/micronized form may vary)
Impurities: Related compounds within acceptable pharmaceutical standards; minor organic and inorganic impurities
Other Ingredients: None present at reportable levels
Inhalation: Remove individual to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Rinse thoroughly with water, remove contaminated clothing, consult a physician for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if easy, continue rinsing, obtain medical advice if discomfort continues
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical advice
Notes for Doctors: Treat symptomatically, monitor for allergic response, supportive care may be required
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Hazardous Combustion Products: Carbon monoxide, nitrogen oxides, hydrogen chloride gas may be released
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Specific Hazards: Powder dust can form explosive mixtures with air under certain conditions
Personal Precautions: Avoid dust formation, use personal protective equipment, ventilate affected area
Environmental Precautions: Do not allow spilled material to reach drains or water sources
Clean-Up Methods: Sweep up without generating dust, place in designated waste container, wash area with water
Disposal: Refer to local regulations for safe disposal of collected material
Handling: Handle under local exhaust ventilation, avoid contact with eyes and skin, avoid inhalation of dust, use appropriate protective gear
Storage: Store tightly closed in a cool, dry, well-ventilated space, protect from moisture, light, and temperature extremes
Incompatible Materials: Strong oxidizers, strong acids or alkalis
Engineering Controls: Use local exhaust or process enclosure to minimize airborne dust
Personal Protective Equipment: Safety glasses or goggles, gloves (nitrile or latex recommended), lab coat, approved dust respirator if exposure to airborne particles is possible
Workplace Hygiene: Wash hands before breaks and after work, do not eat, drink, or smoke in work area
Exposure Limits: No specific occupational exposure limits established; minimize exposure as prudent practice
Appearance: Yellow crystalline powder
Odor: Odorless
pH: 2.5 - 3.5 (1% aqueous solution)
Melting Point: 220-225°C (with decomposition)
Solubility: Slightly soluble in water; soluble in acids
Boiling Point: Not applicable (decomposes before boiling)
Partition Coefficient: Not available
Flash Point: Not established
Vapor Pressure: Not applicable
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Avoid strong oxidizers and strong acids
Possibility of Hazardous Reactions: No dangerous reactions expected with correct handling
Decomposition Products: Toxic fumes may form under fire conditions
Conditions to Avoid: Moisture, direct sunlight, excessive heat
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) estimated >5000 mg/kg; not classified as acutely toxic
Skin Irritation: Mild irritation possible
Eye Irritation: Moderate irritation possible
Chronic Effects: Prolonged or repeated exposure may cause allergic skin reactions, photosensitivity
Carcinogenicity: Not classified by IARC, ACGIH, NTP, or OSHA
Mutagenicity: No significant evidence from available studies
Reproductive Toxicity: May affect fetal development if administered during pregnancy (animal studies)
Aquatic Toxicity: Harmful to aquatic organisms based on related antibiotics
Persistence and Degradability: May persist in the environment; biodegradability information limited
Bioaccumulative Potential: No data; potential for bioaccumulation considered low
Mobility in Soil: Minimal mobility due to low solubility
Other Adverse Effects: Large releases can disrupt microbial activity in wastewater treatment
Disposal Methods: Incineration in permitted facility preferred, disposal must comply with national and local regulations
Contaminated Packaging: Dispose as unused product, triple rinse and offer for recycling if possible
Precautions: Avoid release to environment, keep out of sewer, surface water, and soil
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not classified
Special Precautions: Keep container tightly closed, protect from rough handling
Inventory Status: Listed or in compliance with major inventories (TSCA, EINECS/ELINCS, DSL, etc.)
Labeling: GHS-compliant label required for handling and storage outside pharmaceutical manufacturing
Regulatory Restrictions: Active pharmaceutical ingredient–use governed by drug regulations
SARA/Title III: Not reportable
California Prop 65: Not listed
Other Safety Laws: Country- or state-specific restrictions and licensing for manufacture or use may apply
