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Product Name: Micafungin Nucleus
Chemical Family: Echinocandin Antifungal
Synonyms: None known for nucleus intermediate
CAS Number: Assigned to the active substance, variations for intermediates
Recommended Use: Pharmaceutical synthesis, research
Supplier Details: Sourcing department or pharmaceutical manufacturer/contact
Emergency Number: Available from supplier/manufacturer
Classification: Based on GHS, hazard class may include Eye Irritation Category 2A, Skin Sensitizer Category 1B, Specific Target Organ Toxicity on single exposure
Signal Word: Warning
Hazard Statements: May cause skin, eye, and respiratory irritation, may sensitize with repeated contact
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust/fumes, wash thoroughly after handling, wear protection, seek medical advice after exposure
Chemical Identity: Intermediate in syntheses of active micafungin
Purity: Above 95% by chromatographic analysis
Impurities: By-product traces, residual solvents below regulatory thresholds
Main Constituents: Echinocandin nucleus-related molecules, minimal additives
Molecular Weight: 700-1100 g/mol typical for nucleus basis
CAS Number: Assigned per synthetic stage
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses, seek medical review
Skin Contact: Immediately wash with soap and water, remove contaminated clothing, medical attention if irritation develops
Inhalation: Move to fresh air, monitor breathing, get medical help if symptoms continue
Ingestion: Rinse mouth with water, consult medical personnel, do not induce vomiting
Most Important Symptoms: Possible mild irritation; severe cases might include delayed allergic responses
Special Notes: Clinical intervention depends on symptoms, provide the SDS to caregivers
Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide for small fires
Hazards: Combustion may release toxic fumes including oxides of carbon, nitrogen, sulfur
Protective Equipment: Full protective suit, self-contained breathing equipment
Procedures: Remove non-essential personnel, contain water used in firefighting to prevent environmental contamination
Special Hazards: Powder can create dust explosion risk in certain conditions
Personal Precautions: Use respiratory protection, gloves, goggles, prevent dust formation
Spill Cleanup Methods: Sweep up avoiding dust, ventilate area, collect in suitable container for disposal
Environmental Precautions: Prevent runoff to sewers or waterways, notify authorities if contamination occurs
Decontamination: Clean spilled site with detergent; avoid solvent-based cleaning for powder
Disposal: According to local, federal, national regulations
Handling: Keep containers tightly closed, handle in area with good local ventilation, avoid contact and inhalation
Storage Conditions: Store away from direct light, humidity, and incompatible substances; temperatures between 2°C and 8°C
Incompatible Materials: Strong oxidizers, acids, bases, reactive chemicals
Special Requirements: Dedicated chemical storeroom, controlled access for authorized personnel
Additional Measures: Use closed processes or local exhaust, label containers clearly
Exposure Limits: No occupational exposure limits set for nucleus, precautionary approach advised
Engineering Controls: Work in certified chemical fume hood, ensure emergency eyewash and showers present
Personal Protection: Chemical-resistant gloves (nitrile recommended), tight safety goggles, lab coat, suitable mask (P3/HEPA for powder)
Hygiene Practices: Remove contaminated clothing immediately, wash hands after handling, keep food away from work area
Environmental Controls: Filtration or scrubbing of exhaust air
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic odor
Odor Threshold: Not determined
pH: Solution-specific (usually near neutral)
Melting Point/Freezing Point: 230-250°C approximate, decomposition likely above 200°C
Boiling Point: Decomposes without boiling
Flash Point: Not flammable in aqueous suspension
Evaporation Rate: Not applicable
Solubility: Sparingly soluble in water, more soluble in DMSO, DMF, methanol
Vapor Pressure: Negligible
Density: 1.2-1.4 g/cm³ estimated
Partition Coefficient: Log Pow estimated below 3
Decomposition Temperature: Above 200°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Inert to most lab reagents under ambient conditions
Conditions to Avoid: Moisture, high temperature, incompatible substances
Materials to Avoid: Strong oxidizers, acids, alkali, peroxides
Hazardous Decomposition: Toxic vapors, including carbon monoxide, carbon dioxide, and oxides of nitrogen/sulfur in fire
Polymerization: Will not occur
Acute Toxicity: Oral and dermal toxicity data limited; animal studies suggest low to moderate toxicity
Inhalation: Large amounts may cause symptoms like headaches, dizziness, or respiratory tract irritation
Skin Irritation: Possible mild irritation on repeated contact; allergic dermatitis reported in susceptible individuals
Eye Irritation: Powder or dust may irritate eyes
Chronic Exposure: Not fully studied, but structural similarity to related compounds suggests low chronic risk at occupational levels
Sensitization: Possible in sensitive individuals
Data Sources: Evaluations based on animal, in vitro, and similar chemical reports
Toxicity to Aquatic Life: Limited data; similar compounds may harm aquatic fungi, invertebrates at high concentrations
Persistence and Degradability: Expected to show moderate environmental persistence due to molecular complexity
Bioaccumulation Potential: Low; structure resists lipid absorption
Mobility: Substance not very mobile in soil; binds to organic matter
Other Adverse Effects: Avoid release to environment; pharmaceutical effluent requires special management for wastewater treatment
Waste Treatment Methods: Small amounts can be incinerated; large volumes should use licensed hazardous chemical disposal
Contaminated Packaging: Dispose of like laboratory waste containers after triple-rinsing, or via incineration
Special Precautions: Avoid landfilling, do not pour into drains
Legal Requirements: Follow regional, national, local hazardous waste regulation
UN Number: Not classified for transport as dangerous goods
Transport Hazard Class: Not regulated under international ADR/RID/IMDG/IATA codes
Packing Group: Not assigned
Transport Label: None required in most regions
Special Transport Precautions: Ship in tightly sealed container, avoid temperature extremes, protect from physical damage
Regulatory Notes: For research or regulated medical use, other transport requirements might apply
Safety Assessment: Evaluated for workplace and environmental hazard in key markets
Regulatory Status: Precursor/intermediate not scheduled under global conventions
Label Requirements: Hazard labeling, use classification pictograms as per region
Chemical Inventories: Not listed as finished API; precursor use may be regulated under local pharmaceutical or chemical law
Additional Regulatory Information: Compound under active regulation regarding synthesis for finished drug substance; environmental and occupational rules apply based on usage and handling volume
