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Product Name: Mevastatin
Chemical Name: (1S,3R,7S,8S,8aR)-8-{(2R,4R)-4-hydroxy-6-oxooxan-2-yl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
Synonyms: Compactin, ML-236B
CAS Number: 73573-88-3
Recommended Use: Research and pharmaceutical development
Supplier Identification: Name, address, and contact details of supplier
Emergency Phone: Available 24 hours, listed by supplier or local poison control
Classification: Specified as harmful if swallowed, irritating to skin, eyes, and respiratory tract
GHS Label Elements: Pictogram indicating health hazard, harmful/irritant symbol
Signal Word: Warning
Hazard Statements: Causes skin/eye irritation, may cause allergic reactions, harmful if inhaled or ingested
Precautionary Statements: Avoid breathing dust, use protective gloves/eye protection, wash hands thoroughly after handling, do not eat, drink, or smoke during use
Other Hazards: Occupational exposure potentially causes organ damage through prolonged or repeated contact
Chemical Identity: Mevastatin
Purity: Typically >98% by HPLC
Impurities: Trace solvents, related statin compounds (usually <2%)
Molecular Formula: C23H34O5
Molecular Weight: 390.51 g/mol
Component Analysis: No additional hazardous components disclosed within the formulation beyond those intrinsic to mevastatin
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and plenty of water, remove contaminated clothing, consult physician if symptoms develop
Inhalation: Move exposed person to fresh air, position comfortably for breathing, provide oxygen or artificial respiration if needed, get medical attention for symptoms
Ingestion: Rinse mouth, do not induce vomiting, give water if person is conscious, call a physician or poison center immediately
Most Important Symptoms: Potential irritation, allergy-like symptoms, possible systemic toxicity at high or repeated doses
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder or appropriate foam
Unsuitable Media: Avoid water jet as this spreads fire
Special Hazards from Combustion: Carbon oxides, toxic fumes, unidentified organic compounds
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Other Recommendations: Remove containers from fire area if possible, avoid inhalation of combustion products, prevent run-off from fire control from entering waterways
Personal Precautions: Wear gloves, safety goggles, dust mask or respirator suited for powders, avoid direct contact, provide adequate ventilation
Environmental Precautions: Prevent entry into soil, sewers, drains, and waterways, inform authorities if large spill contaminates environment
Cleanup Methods: Sweep up without creating dust, place in closed container for disposal, ventilate area, wash spill site after material disposal, dispose of contaminated clothing appropriately
Handling: Avoid skin and eye contact, prevent dust formation, use in well-ventilated areas, keep away from incompatible chemicals like strong oxidizers, do not eat or drink near material
Hygiene Measures: Wash hands and face after handling, clean protective gear before reuse, maintain good industrial hygiene practice
Storage Conditions: Store in tightly closed containers at 2–8°C, keep dry and in original packaging, protect from light, moisture, and incompatible substances
Incompatible Materials: Strong acids and bases, oxidizing agents
Specific Storage Requirements: Use secure, labeled chemical storage, restrict access to trained personnel
Engineering Controls: Work in chemical fume hood or ventilated enclosure, use local exhaust
Exposure Limits: No established occupational exposure limits for mevastatin, minimize dust exposure
Personal Protection: Wear latex/nitrile gloves, lab coat, safety goggles with side shields, N95 (or higher) particulate respirator for powder handling, ensure eye wash and emergency shower access nearby
Environmental Controls: Prevent powder from entering drains or waterways, use spill containment practices
Appearance: White or off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined (practically insoluble in water)
Melting Point / Freezing Point: 160–166°C (decomposition)
Boiling Point: Not determined
Flash Point: No data available
Evaporation Rate: Not applicable
Flammability: Not readily flammable
Vapor Pressure: Not measured (very low)
Solubility: Practically insoluble in water, soluble in methanol, ethanol, and DMSO
Partition Coefficient: log Pow ≈ 4–5
Auto-ignition Temperature: No data
Decomposition Temperature: Above 160°C
Viscosity: Not relevant (solid powder)
Chemical Stability: Stable under recommended storage conditions, dry at 2–8°C
Reactivity: Non-reactive in normal laboratory use
Stability: Sensitive to moisture, may degrade in presence of strong acids, bases, or light
Hazardous Reactions: May react with oxidizers to form hazardous compounds
Decomposition Products: Releases carbon oxides and other unknown toxic vapors if burned or decomposed
Conditions to Avoid: Excessive heat, light, moisture, open flames
Routes of Exposure: Eyes, skin, inhalation, ingestion
Acute Toxicity: Oral LD50 not precisely defined, potentially low to moderate toxicity in mammals
Skin Corrosion/Irritation: May cause mild to moderate irritation
Eye Damage/Irritation: Potential for redness, watering, discomfort
Respiratory or Skin Sensitization: Possible allergic response with repeated or prolonged exposure
Chronic Effects: Animal tests show liver and muscular changes with repeated high doses, human risk relates mainly to workplace exposure
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogen; long-term organ effects possible, more data needed for risk assessment
Other Data: Not listed as a known carcinogen or reproductive hazard by IARC, NTP, or OSHA
Ecotoxicity: Harmful to aquatic organisms at high concentrations, avoid environmental release
Persistence and Degradability: Mevastatin likely to persist in environment over short term, not readily biodegradable
Bioaccumulative Potential: Possible bioaccumulation due to log Pow value
Mobility in Soil: Limited mobility, binds to soil constituents
Other Adverse Effects: No detailed ecosystem studies available; prudent handling advised to minimize release
Disposal Methods: Dispose in accordance with local, regional, and national regulations, hazardous chemical waste container
Contaminated Packaging: Clean prior to disposal or treat as hazardous waste
Special Disposal Precautions: Prevent spill or contaminant release, do not dispose in household waste or drains
UN Number: Not classified as hazardous for most transport modes
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not defined
Environmental Hazards: Not identified as marine pollutant
Special Precautions: Package securely to prevent breakage and dust release, follow local legal requirements
Safety, Health, Environmental Regulations: No specific guidelines under major chemical safety acts, but general handling prescribed under OSHA Laboratory Standard, Chemical Hygiene Plan, and local workplace safety regulations
Inventory Status: Not listed on the US TSCA Inventory as a commercial substance; research uses may be exempt
Other Regulatory Listings: No CERCLA, SARA, or California Proposition 65 listings
Labelling Requirements: Standard laboratory risk symbols, R and S phrases as per relevant jurisdiction
Workplace Controls: Require training, written safety practices, incident documentation
