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Product Name: Metoprolol Tartrate
Synonyms: 1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L-tartrate; Lopressor
Chemical Formula: C15H25NO3 • C4H6O6
Molecular Weight: 684.82 g/mol
Recommended Use: Used as a beta-blocker in the treatment of hypertension, angina, heart failure
Supplier Details: Contact information available through distributor or manufacturer
Emergency Contact: Local Poison Control Center, medical professional, or local emergency services
GHS Classification: Not classified as hazardous according to OSHA Hazard Communication Standard
Hazard Statements: May cause cardiovascular, respiratory, or central nervous system effects with overexposure
Signal Word: Caution
Hazard Symbol: Not required under GHS guidelines
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Potential Health Effects: Headache, dizziness, bradycardia, hypotension, fatigue; prolonged exposure could aggravate underlying health conditions involving heart or lungs
Environmental Impacts: Not expected to cause significant adverse effects in aquatics or environment at typical concentrations
Active Ingredient: Metoprolol Tartrate
CAS Number: 56392-17-7
Percentage (%): 98–100% (pure substance)
Other Components: Pharmaceutical formulations may contain fillers, binders, or colorants; excipient composition varies by manufacturer
Impurities: Not known to contain hazardous impurities at significant levels based on available data
Inhalation: Move exposed person to fresh air; seek medical attention for persistent symptoms
Skin Contact: Wash area with soap and water; remove contaminated clothing; medical attention if irritation develops
Eye Contact: Rinse eyes cautiously with water for several minutes; remove contact lenses if present; seek medical advice if irritation persists
Ingestion: Rinse mouth with water; do not induce vomiting; call Poison Control or medical professional
Most Important Symptoms: Slow or irregular heartbeat, faintness, tiredness, labored breathing
Suitable Extinguishing Media: Use water spray, dry chemical powder, carbon dioxide, or foam
Specific Hazards: Product is not considered highly flammable; thermal decomposition could produce oxides of carbon and nitrogen
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective gear
Fire/Explosion Risks: Dust may form explosive mixtures with air; avoid dust generation and accumulation
Special Procedures: Prevent runoff from entering drains or water sources; cool fire-exposed containers with water spray
Personal Precautions: Avoid dust formation; ventilate area; use appropriate personal protective equipment
Spill Response: Sweep up spilled material without creating dust; dispose of in accordance with local regulations
Environmental Precautions: Prevent product from entering soil, waterways, or drains; notify authorities if large quantities enter the environment
Cleanup Methods: Use damp cloth or absorbent material to remove residue; wash contaminated surfaces with soap and water
Handling Recommendations: Use adequate ventilation; avoid breathing dust; wash hands thoroughly after handling
Safe Storage Requirements: Keep container tightly closed in a cool, dry, well-ventilated area
Packaging Materials: Store in original packaging or compatible container; protect from moisture and light
Incompatibilities: Strong acids, bases, oxidizing agents may react with product; separate from incompatible materials
Hygiene Measures: No eating, drinking, or smoking in area where material is handled or stored
Engineering Controls: Use local exhaust ventilation if dust is generated; safety shower and eyewash station nearby
Personal Protective Equipment:
Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Odor Threshold: Not applicable
pH: 5–7 (1% solution in water)
Melting Point/Freezing Point: 120–124°C (decomposes)
Boiling Point/Range: Not available
Flash Point: Not available
Evaporation Rate: Not applicable
Flammability: Not flammable by standard testing
Solubility: Freely soluble in water, alcohol, chloroform; slightly soluble in acetone, ether
Vapor Pressure: Not applicable
Relative Density: Approximately 1.2 g/cm³
Partition Coefficient (log Kow): 1.88–1.89
Decomposition Temperature: >120°C
Chemical Stability: Stable under normal conditions of storage and handling
Reactivity: No dangerous reaction known under normal conditions
Conditions to Avoid: Extreme heat, open flame, exposure to moisture or direct sunlight
Incompatible Materials: Strong oxidizing agents, acids, strong bases
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, possibly toxic fumes
Likely Routes of Exposure: Inhalation, ingestion, dermal contact
Acute Toxicity: Oral LD50 (rat): 2,090 mg/kg; low acute toxicity for single exposure
Chronic Effects: Long-term use leads to bradycardia, hypotension, heart failure, bronchospasm in susceptible people
Skin/Eye Irritation: Not classified as a primary skin or eye irritant
Carcinogenicity: Animal data do not show evidence of carcinogenicity; not listed by IARC, NTP, or OSHA
Reproductive Toxicity: No clear evidence of reproductive toxicity from available studies
Sensitization: Not reported to cause skin or respiratory sensitization
Ecotoxicity: Data on aquatic toxicity limited; not expected to bioaccumulate or persist
Mobility in Soil: Soluble in water, potential to move through soil to groundwater
Biodegradability: Likely biodegradable but rate may vary depending on environmental conditions
Persistence: Not considered persistent under normal environmental conditions
Bioaccumulation Potential: Low based on chemical structure and partition coefficient
Aquatic Toxicity: No significant impact predicted at relevant concentrations
Disposal Methods: Dispose of in accordance with all local, regional, and national regulations
Packaging Disposal: Empty containers must be triple rinsed before disposal or sent for incineration or recycling
Precautions: Avoid direct disposal to sewers or waterways; incinerate under controlled conditions where permitted
Unused Product: Never discharge unused product into the environment or public water systems
UN Number: Not regulated as a hazardous material
DOT Classification: Not classified as dangerous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Proper Shipping Name: Metoprolol Tartrate, not restricted
Environmental Hazards: No marking required
Special Precautions: Protect packaging from extreme temperature and direct moisture during transit
OSHA Status: Not specifically regulated under the OSHA Hazard Communication Standard
TSCA Status: Exempt as a pharmaceutical
SARA Title III: Not classified as a hazardous chemical; not a listed hazardous substance
CERCLA Reportable Quantity: Not applicable
California Proposition 65: Not listed as a chemical known to cause cancer, birth defects, or other reproductive harm
WHMIS Classification (Canada): Not controlled
Other Regulatory Info: Pharmaceutical substances typically require oversight under local, state, and national drug safety laws
