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Product Name: Metoclopramide Hydrochloride
Chemical Name: 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide hydrochloride
Common Synonyms: Metoclopramide; Maxolon; Reglan
CAS Number: 364-62-5
Recommended Use: Pharmaceutical active substance, antiemetic
Supplier Identification: Name: [Supplier]; Address: [Location]; Telephone: [Contact Number]; Emergency Telephone: [Emergency Contact Line]
Formula: C14H22ClN3O2·HCl; Molecular Weight: 354.3 g/mol
Classification: Acute Toxicity (Oral, Dermal); Skin Irritation; Eye Irritation; Target Organ Toxicity; Hazardous to the Aquatic Environment
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause allergic skin reaction, causes mild to moderate eye irritation, may cause adverse effects to the central nervous system and gastrointestinal system, harmful to aquatic life
Precautionary Statements: Avoid skin and eye contact, use personal protective equipment, wash thoroughly after handling, avoid release to the environment
Main Ingredient: Metoclopramide Hydrochloride
Concentration: >98%
Impurities: May contain trace quantities of related substances, residual solvents
Additives: None present in raw API
Inhalation: Move to fresh air, ensure clear airways, seek medical help for respiratory distress or persistent symptoms
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap, seek medical attention if irritation or symptoms occur
Eye Contact: Rinse eyes with clean water for at least 15 minutes, remove contact lenses if present and easy to do, get medical attention if irritation persists
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical advice, monitor for nausea, vomiting, central nervous system effects
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Media: Strong water jets
Fire and Explosion Hazards: Fine powder may form explosive dust-air mixtures, thermal decomposition or combustion may release toxic and corrosive gases including hydrogen chloride, nitrogen oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus (SCBA) and full protective gear
Special Precautions: Control runoff water, minimize contamination to drains and watercourses
Personal Precautions: Ventilate area, keep unnecessary personnel away, avoid inhalation and skin contact, use personal protective equipment
Spill Cleanup: Avoid dust generation, absorb spills with inert material, sweep up and shovel into suitable containers for disposal
Environmental Precautions: Prevent entry into drains or waterways, notify relevant authorities in case of large spills
Methods for Disposal: Collect residues in sealable containers, label clearly for hazardous waste handling
Handling: Use in a well-ventilated space, avoid contact with eyes, skin, clothing, and do not breathe dust, do not eat, drink, or smoke during handling, wash hands thoroughly after use
Storage: Store in tightly closed original container, keep away from heat, direct sunlight, incompatible substances (strong oxidizers, acids), keep in a dry, cool, and well-ventilated place
Storage Temperature: 15–30°C (room temperature), avoid freezing or excessive heat
Incompatibilities: Strong oxidizing agents, strong acids
Engineering Controls: Use local exhaust ventilation to minimize dust exposure, safety showers and eye wash stations should be available in work area
Personal Protective Equipment: Eyes: Safety goggles or face shield; Hands: Impervious gloves (nitrile or latex); Skin: Protective clothing, lab coat; Respiratory Protection: Approved dust mask or respirator when dust generation likely
Hygiene Measures: Wash hands after handling, remove and clean contaminated clothing, avoid splashing or airborne particles
Occupational Exposure Limits: No established exposure limits, use caution and apply standard pharmaceutical controls
Physical State: Solid, crystalline powder
Color: White to slightly yellowish
Odor: Odorless
pH (1% solution): Approximately 4.5–6.5
Melting Point: 147–150°C
Boiling Point: Not applicable (decomposes)
Solubility: Freely soluble in water, sparingly soluble in ethanol
Relative Density: Approximately 1.2 g/cm³
Partition Coefficient: log P (octanol/water): -0.3
Vapor Pressure: Not relevant (non-volatile solid)
Other Data: Stable under normal conditions of use and storage
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No dangerous reactions known under normal use
Conditions to Avoid: Heat, light, moisture, incompatible materials
Incompatible Materials: Strong oxidizers, acids, alkalis
Hazardous Decomposition Products: Toxic fumes including hydrochloric acid, nitrogen oxides, carbon monoxide, and carbon dioxide on thermal decomposition
Polymerization: Will not occur
Acute Toxicity: Oral LD50 (rat): ~300–500 mg/kg
Skin Corrosion/Irritation: May cause skin irritation on prolonged or repeated exposure
Serious Eye Damage/Irritation: Can cause eye irritation
Respiratory or Skin Sensitization: May cause allergic reactions in susceptible individuals
Carcinogenicity: Not classified as carcinogen by NTP, IARC, OSHA
Reproductive Toxicity: Studies show potential for adverse effects in fetus at high doses
Other Effects: May induce extrapyramidal symptoms, drowsiness, gastrointestinal distress, and, at overdose, central nervous system depression
Chronic Exposure: Prolonged exposure may affect liver, kidneys, blood parameters
Aquatic Toxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Not readily biodegradable, persists in some environmental compartments
Bioaccumulative Potential: Low potential for bioaccumulation (log Kow: -0.3)
Mobility in Soil: Moderate to high mobility in aqueous systems
Other Information: Avoid uncontrolled release to the environment, pharmaceutical residues can impact aquatic and soil biota
Disposal Methods: Handle as hazardous pharmaceutical waste, dispose through licensed waste management contractor
Unused Material: Incinerate in a chemical incinerator equipped with afterburner and scrubber
Contaminated Packaging: Dispose of as hazardous waste, clean before recycling if possible
Regulatory Requirements: Follow local, regional, and national regulations for pharmaceutical and chemical disposal
UN Number: Not classified as dangerous goods under UN transport regulations
Proper Shipping Name: Not regulated for transport
Hazard Class: None assigned
Packing Group: None assigned
Environmental Hazards: Avoid spillage during transport, follow best containment practices
Special Precautions: Secure packaging, avoid conditions that might damage containers
Labelling: Follow labeling laws for active pharmaceutical ingredients
Inventory Status: Listed in US TSCA, EU EINECS, Canada DSL/NDSL
Regulatory Controls: Subject to GMP requirements as pharmaceutical raw material, controlled under various national and regional health and safety regulations
OSHA Hazard Communication: Hazardous chemical under OSHA Hazard Communication Standard, 29 CFR 1910.1200
Other Specific Regulations: Ensure compliance with GHS, REACH, WHMIS, and other applicable directives
