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Product Name: Methylsynephrine
Chemical Name: 4-[1-hydroxy-2-(methylamino)ethyl]phenol
CAS Number: 94-07-5
Synonyms: Oxilofrine, p-Hydroxyephedrine
Recommended Use: Research, Laboratory Chemical
Manufacturer: Chemical suppliers typically associated with laboratory reagents
Emergency Contact: Poison Control Center or local emergency line
GHS Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A, Specific Target Organ Toxicity – Single Exposure Category 3
Pictograms: Exclamation Mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed, Causes serious eye irritation, May cause respiratory irritation
Precautionary Statements: Avoid breathing dust or fumes, Wash hands thoroughly after handling, Wear safety glasses and gloves, Do not eat or drink while using this substance, Use only outdoors or in a well-ventilated area
Chemical Name: Methylsynephrine
Concentration: ≥98% as the main ingredient
Impurities: Trace organic impurities common for synthesis, usually not individually specified
Molecular Formula: C9H13NO2
Molecular Weight: 167.21 g/mol
Form: Solid powder or crystalline substance, typically white or off-white
Eye Contact: Rinse with water for several minutes, remove contact lenses if present, seek medical help if irritation persists
Skin Contact: Wash with plenty of water and soap, remove contaminated clothing, consult a doctor if symptoms develop
Inhalation: Move to fresh air at once, provide artificial respiration if breathing stops, seek immediate medical assistance
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, get prompt medical attention
Important Symptoms and Effects: May provoke rapid heartbeat, anxiety, nausea, respiratory irritation, eye redness, or skin reactions
Immediate Medical Attention: Essential for large exposures or if severe symptoms develop
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, or water spray
Unsuitable Media: Do not use strong jets of water near dust due to potential for spreading
Specific Hazards: May emit toxic fumes of nitrogen oxides and carbon oxides during combustion
Protective Equipment: Firefighters use self-contained breathing apparatus, protective suit, avoid inhaling smoke
Special Precautions: Combustible dust can ignite in air under appropriate conditions, avoid buildup and dispersion
Personal Precautions: Don gloves, goggles, dust mask or respirator, limit exposure to all unnecessary personnel
Environmental Precautions: Prevent from entering drains, surface water, or soil
Cleanup Methods: Scoop up spilled solid, avoid dust generation, ventilate area, dispose in sealed container
Decontamination: Wash contaminated surface with soapy water, ventilate area thoroughly afterward
Safe Handling: Work in fume hood or well-ventilated space, minimize dust formation, wash hands after handling, avoid inhalation or contact
Storage Conditions: Store in tightly closed containers, in cool, dry, ventilated space, avoid sunlight and extremes of temperature
Incompatibilities: Acids, strong oxidizers, bases, sources of ignition or strong reducing agents
Packaging: Use containers made from non-reactive material, clearly labeled
Engineering Controls: Fume hoods or local exhaust required, equipment for dust control
Personal Protection: Chemical splash goggles for eyes, nitrile or similar gloves for hands, lab coat for skin protection, NIOSH-approved respirator for airborne dust
Hygiene Measures: Plenty of hand washing, no eating or drinking in labs, clean contaminated clothing before reuse
Exposure Limits: No established ACGIH TLV or OSHA PEL, workplace limits not well defined—handle with care as a potential drug compound
Appearance: White or off-white crystalline powder
Odor: Nearly odorless
pH: Not available
Melting Point: Approximately 157°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, soluble in alcohol
Vapor Pressure: Not available
Density: Estimated around 1.18 g/cm³
Partition Coefficient: Not measured directly
Flash Point: Not determined due to solid state
Chemical Stability: Stable under recommended handling and storage
Reactivity: Not highly reactive, but can react with oxidizers or acids
Hazardous Reactions: May produce hazardous fumes in fire
Conditions to Avoid: Excess heat, direct sunlight, moisture, sources of ignition
Incompatible Materials: Strong oxidizers, acids, reducing agents
Hazardous Decomposition Products: Emits nitrogen oxides, carbon monoxide and dioxide if burned
Acute Toxicity: Harmful if swallowed, some evidence of cardiovascular effects in animal studies, LD50 not precisely established
Eye Damage: Causes moderate to severe irritation
Skin Irritation: Slight irritation possible
Respiratory Sensitization: Dust can provoke coughing, shortness of breath
Chronic Exposure: Repeated exposure may affect heart rate, cause hypertension, restlessness
Route of Exposure: Primarily oral, but all routes present some hazards
Carcinogenicity: No long-term data available, not classified as carcinogen
Mutagenicity: No evidence found
Reproductive Effects: Not tested systematically in humans
Ecotoxicity: Data sparse, not expected to be highly toxic to aquatic life at low concentrations
Bioaccumulation Potential: No significant potential based on its solubility
Degradability: Breakdown in environment believed to be moderate via standard biochemical processes
Mobility in Soil: Will travel with water if spilled, minimal adsorption to soil
Other Harmful Effects: Be cautious about release, as pharmaceutical agents can disrupt local microflora if chronic exposure occurs
Waste Generators: Treat as hazardous laboratory chemical waste
Disposal Methods: Place in sealed, properly labeled, container, incinerate via licensed provider if possible
Prohibited Disposal: Do not pour down drain, do not discard in regular trash
Environmental Precautions: Prevent chemical from entering waterways or sewer systems
Container Cleaning: Triple-rinse empty containers prior to discarding, follow local chemical hygiene practices
UN Number: Not assigned for small laboratory quantities
Shipping Name: Laboratory chemical, not regulated for transport in most jurisdictions
Transport Hazard Class: Not classified under most regulatory schemes due to research quantities
Packing Group: Not assigned
Precautions: Ship in tightly sealed containers, provide SDS to carriers, avoid moisture and rough handling
TSCA Inventory: Methylsynephrine not listed as a regulated substance
REACH Status: Not subject to European REACH registration in research usage
State Regulations: Focus on local regulations, some jurisdictions may control as analog of pharmaceutical substances
SARA Title III: Not listed as reportable hazardous substance
Other Labels: Marked “for research use only,” not approved for food or drug use
Laboratory Standards: Handle according to standard laboratory safety protocols and local workplace chemical hygiene plans
