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Product Name: Methylprednisolone
Chemical Name: 6α-Methylprednisolone
Synonyms: Medrol, Depo-Medrol, Solu-Medrol
CAS Number: 83-43-2
Molecular Formula: C22H30O5
Molecular Weight: 374.47 g/mol
Manufacturer: Pharmaceutical suppliers and chemical companies
Recommended Use: Anti-inflammatory and immunosuppressive medication
Emergency Phone: Refer to local poison control center
Address: Refer to specific supplier’s contact
Emergency Overview: White or off-white powder or crystalline substance, no significant odor reported, not classified for acute toxicity under GHS
Main Hazards: Mild irritation to skin, eyes, respiratory system at high exposure; may cause allergies or hypersensitivity in susceptible individuals; risk increases after frequent handling without protective gear
GHS Label Elements: Not a hazardous substance as per GHS classification
Signal Word: Not applicable
Pictograms: Not required
Precautionary Statements: Avoid inhalation, ingestion, or extended contact with skin and eyes; observe safe laboratory or workplace hygiene
Other Hazards: Medication misuse can trigger systemic side effects; not environmentally hazardous in low volumes but spills should be minimized
Chemical Name: Methylprednisolone
Concentration: 100% in pure form; pharmaceutical forms contain excipients such as lactose, sodium succinate as appropriate
CAS Number: 83-43-2
EC Number: 201-482-7
Impurities: None significant in pharmaceutical grade preparation
Additives: Tablets or vials may include stabilizers or fillers
Inhalation: Move affected person to fresh air; seek medical attention for unusual symptoms like coughing, shortness of breath, or difficulty breathing
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; medical review for persistent irritation or rash
Eye Contact: Flush eyes immediately with plenty of water for 15 minutes, holding eyelids apart; seek eye care for pain, redness, or visual changes
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel; get prompt medical advice if self-medication is suspected
Note for Doctors: Symptomatic and supportive treatment; look for allergic responses and steroid-induced complications in repeated exposure scenarios
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, foam, or water spray for fires involving this chemical
Unsuitable Extinguishing Media: Avoid direct water stream for safety
Specific Hazards: Combustion may produce irritating or toxic fumes including oxides of carbon
Protective Equipment for Fire Fighters: Wear self-contained breathing apparatus, full protective gear, chemical-resistant suit where needed
Special Procedures: Prevent run-off from entering drains and water courses; cool fire-exposed containers
Personal Precautions: Use personal protective equipment including gloves, lab coat, and eye protection; avoid creation of dust
Environmental Precautions: Prevent further leakage or spillage if safe; avoid discharge into drains, water courses, or soil
Spill Clean-Up: Clean with HEPA-filter vacuum or moistened absorbent material; avoid dry sweeping; transfer collected material to suitable waste container
Other Measures: Ventilate area and wash spillage site after material pickup is complete
Safe Handling: Avoid contact with eyes, skin, and clothing; minimize airborne dust generation; wash hands after handling
Technical Precautions: Use only in well-ventilated areas, employ local exhaust ventilation if dust risk appears
Storage Conditions: Store in original, tightly closed container; keep away from direct sunlight, heat, and moisture; preferred storage temperature is 15-30°C (59-86°F)
Incompatibilities: Strong oxidizing agents
Storage Area: Secure, well-marked medical or laboratory facility, limiting unauthorized access
Occupational Exposure Limits: No occupational exposure limit value established for this compound
Engineering Controls: Use process enclosures, local exhaust, or other controls to keep airborne levels as low as possible
Respiratory Protection: Required for high dust levels; approved particulate respirator
Skin Protection: Chemical-resistant gloves, lab coat, long sleeves to minimize direct skin contact
Eye Protection: Safety goggles or face shield in high-contact environments
Hygiene Measures: Do not eat, drink, or smoke where this material is handled; wash hands and remove contaminated clothing immediately after use
Appearance: White to practically white, odorless, crystalline powder
Odor: Odorless
pH: Not determined
Melting Point: 238-241°C (460-466°F)
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Solubility: Practically insoluble in water, soluble in methanol, ethanol, dimethyl sulfoxide, acetone
Partition Coefficient: logP (octanol/water): 1.39
Vapor Pressure: Not applicable
Density: ~1.3 g/cm³
Other Properties: Stable under ordinary conditions, not volatile or flammable in standard use
Chemical Stability: Stable at room temperature under recommended storage conditions
Reactivity: Not chemically reactive with most common materials
Incompatible Materials: Avoid contact with strong oxidizers, acids, or bases
Hazardous Decomposition Products: Thermal decomposition may release carbon monoxide, carbon dioxide, and irritating smoke
Conditions to Avoid: Temperature extremes, sources of ignition, direct light, humidity
Acute Toxicity: Low oral toxicity in animal studies (LD50 rat > 1000 mg/kg)
Inhalation: Limited evidence for acute inhalation toxicity, but high exposures may irritate airways
Skin Irritation: May cause mild irritation in sensitive individuals with frequent/prolonged use
Eye Irritation: May cause mild transient discomfort
Sensitization: Rare, though individuals with corticosteroid allergies at risk
Chronic Effects: High doses or repeated overexposure linked to immune suppression, adrenal effects, endocrine disturbance, blood sugar elevation, osteoporosis
Carcinogenicity: No evidence for carcinogenic effects based on animal testing and human clinical experience
Reproductive Toxicity: May affect fetus when taken long-term during pregnancy; consult medical experts for risk assessment
Ecotoxicity: Not readily biodegradable in aquatic systems, unknown toxicity to aquatic life in low concentrations
Environmental Impact: No significant bioaccumulation expected; persistent in the environment at higher concentrations
Degradation: Not expected to hydrolyze rapidly or undergo direct photolysis
Other Adverse Effects: Direct input into water or soil should be avoided; pharmaceuticals can affect aquatic organisms if present in sufficient concentrations
Waste Disposal Methods: Dispose of via incineration or according to local regulations for hazardous pharmaceutical waste; avoid landfill whenever possible
Contaminated Packaging: Treat packaging as hazardous and subject to local or national regulations
Special Precautions: Do not flush down drains or discharge to environment; compliance with environmental management programs for medical waste
UN Number: Not regulated as a hazardous material for transport
Proper Shipping Name: Not applicable for most ground, air, or sea freight
Transport Hazard Class: Not classified as dangerous
Packing Group: Not assigned
Special Transport Precautions: Protect from rough handling, temperature extremes, and moisture; ensure labeling remains intact
EU Regulations: Not classified as hazardous substance or mixture under EC Directive 1272/2008 (CLP/GHS)
US Regulations: Not listed on OSHA HazCom Standard; prescription drug under FDA authority
Other Regulations: Not on List of Extremely Hazardous Substances; pharmaceutical control may limit distribution, sale and handling
SARA/Title III: Not subject to reporting requirements
REACH Status: Exempted as human medicinal product
Maximum Allowable Concentrations: Established by pharmaceutical guidelines, not occupational standards
Other Labeling Requirements: All containers must be clearly labeled and handled according to pharmaceutical safety laws
