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Product Name: Methylcobalamin
Chemical Family: Vitamin B12 analog, Cobalamin Derivative
Molecular Formula: C63H91CoN13O14P
Synonyms: MeCbl, Cobamamide, Coα-Methylcobalamin
CAS Number: 13422-55-4
Recommended Use: Vitamin supplement, clinical research, pharmaceutical compounding
Supplier Details: Fill in company name, address, and emergency contact number relevant to local laws and jurisdictions
Emergency Phone: Refer to local, national, or global chemical emergency contact
GHS Classification: Not classified as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200)
Acute Toxicity: Low; potential for allergies or irritation in susceptible people
Health Hazards: May cause mild eye, skin, or respiratory tract irritation; ingestion considered safe at recommended dosages
Environmental Hazards: Not anticipated with proper containment; always avoid uncontrolled release
Signal Word: None required
Hazard Statements: May cause slight transient discomfort on contact
Precautionary Statements: Avoid unnecessary contact with dust, do not breathe powder, ensure prompt clean-up of spills
Symptoms: Rare hypersensitivity reactions like skin rash, allergic response; symptoms typically mild
Chemical Name: Methylcobalamin
Concentration: ≥97% by weight (pure material)
Additives: None in pure powder; tablet or injectable form may include excipients—see relevant product sheet
Impurities: Trace levels of other B12 analogs may occur, generally below reportable limits
Form: Solid (crystalline powder) or as a solution in water for injection/administration
Inhalation: Move to fresh air; seek medical attention for persistent symptoms
Skin Contact: Wash with soap and water; remove contaminated clothing; medical attention if persistent irritation
Eye Contact: Rinse cautiously with clean water; remove contact lenses if easy; continue rinsing; see medical care if irritation persists
Ingestion: Rinse mouth; drink water if possible; consult a healthcare provider if large quantities or chronic exposure cause concern
Note to Physicians: Symptomatic treatment; rare allergies or sensitivities may require antihistamines or supportive therapies
Flammability: Not considered flammable under normal conditions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam suitable for surrounding material
Hazardous Combustion Products: Decomposition may produce oxides of carbon, nitrogen, cobalt, and phosphorous
Special Protective Equipment: Firefighters use self-contained breathing apparatus and protective clothing
Additional Information: Avoid inhaling smoke or dust from burning material
Personal Precautions: Wear gloves, protective eyewear, avoid dust formation
Environmental Precautions: Prevent entry into drains or surface waters; sweep or vacuum without generating dust
Spill Clean-Up: Collect material in appropriate waste containers for disposal; wash area to remove residues
Decontamination: Use water and mild detergent; ventilate the area well
Precautions for Safe Handling: Avoid inhalation and contact with skin or eyes; wear appropriate PPE; operate in well-ventilated area
Storage Conditions: Store in cool, dry, well-ventilated location; tightly sealed containers; protect from light
Incompatibilities: Strong oxidizers, strong acids, extreme heat
Specific End Uses: Only as intended for laboratory, medical, or supplement use
Engineering Controls: Local exhaust or general ventilation
Personal Protective Equipment: Safety glasses or goggles; gloves resistant to chemicals; lab coat or protective garments
Respiratory Protection: Not required under normal conditions; dust mask if powder forms or airborne particles
Exposure Limits: No occupational exposure limits established, handle as a fine chemical
Hygiene Measures: Wash hands after handling, remove contaminated clothing, avoid eating or drinking in experimental areas
Appearance: Crimson to reddish crystalline powder (pure form)
Odor: Odorless
Molecular Weight: 1344.38 g/mol
Melting Point: 230–240 °C (decomposes)
Solubility: Freely soluble in water, practically insoluble in alcohol and ether
pH (in solution): Typical values 4–7
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible
Density: About 1.87 g/cm³ at 20 °C
Partition Coefficient: Not determined
Chemical Stability: Stable under recommended storage conditions; sensitive to light and heat, decomposes on prolonged exposure
Reactivity: No known dangerous reactions if used properly
Incompatible Materials: Strong oxidizing and reducing agents, bases, acids
Hazardous Decomposition Products: Oxides of carbon, nitrogen, cobalt, and phosphorus when heated to decomposition
Polymerization: Not expected
Acute Toxicity: Low toxicity by oral route in animals and humans
LD50 (oral, rat): >5,000 mg/kg
Skin Irritation: Unlikely; may cause mild irritation in sensitive individuals
Eye Irritation: Unlikely; can cause mild discomfort if particles enter eye
Chronic Effects: Not associated with chronic toxicity at supplement doses
Carcinogenicity: Not identified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence supporting reproductive risk at normal intake levels
Additional Information: Occasional allergic response; risk increases only with exposure to high levels far above nutritional amounts
Ecotoxicity: No specific data indicate significant risk; presumed low environmental hazard due to biological function as a vitamin
Persistence and Degradability: Expected to degrade in the environment through microbial processes
Bioaccumulative Potential: Unlikely to bioaccumulate in aquatic or terrestrial organisms
Mobility in Soil: Highly soluble; likely to disperse with water movement
Other Adverse Effects: None established; prudent practice avoids direct discharge into waterways or soil
Waste Disposal Methods: Dispose according to local, regional, national, and international regulations for pharmaceuticals or lab chemicals
Product/Unused Material: Contain and transfer to an authorized chemical disposal facility; avoid flushing to sewer
Contaminated Packaging: Rinse thoroughly and dispose as chemical waste; if heavily contaminated, treat as hazardous
UN Number: Not applicable
Proper Shipping Name: Not regulated under international or domestic transport guidelines for chemicals
Hazard Class: Not classified
Packing Group: Not assigned
Special Precautions: Protect from excessive heat and direct sunlight, avoid container damage
US Regulations: Not listed as a hazardous substance under CERCLA, SARA Title III, or RCRA
Canada (DSL/NDSL): Included or exempt
European Union: Not classified as dangerous under Regulation (EC) No 1272/2008
Other Inventories: Listed or exempt on Australia AICS, Chinese IECSC, Japanese ENCS (consult national regulations)
Restrictions: Pharmaceutical, nutritional, and laboratory-use only; ensure compliance with relevant health and safety regulations
