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Product Name: Methyl Isobutyrate
Chemical Formula: C5H10O2
Synonyms: 2-Methylpropanoic acid methyl ester
CAS Number: 547-63-7
EC Number: 208-925-3
Recommended Use: Industrial solvent, chemical intermediate, flavoring agent
Manufacturer Contact: Emergency phone numbers, technical information contact, company name and address are required to be clearly supplied on the label and SDS distribution.
Classification: Flammable liquid (Category 3), Eye irritant (Category 2A), Acute toxicity (Inhalation, Category 5)
Label Elements: Pictogram displaying flame, exclamation mark
Signal Word: Warning
Hazard Statements: May cause irritation to eyes. Vapors can lead to drowsiness or dizziness. Flammable in liquid and vapor forms.
Precautionary Statements: Keep away from sparks and heat sources. Use explosion-proof equipment. Ground all containers to prevent static discharge. Avoid breathing vapors. Wear protective gloves and safety goggles during handling.
Chemical Name: Methyl Isobutyrate
Concentration: >99% by weight
CAS Number: 547-63-7
Impurities: Trace levels of water (<0.1%), residual solvents (as low as practically achievable), other volatile organic compounds (as detected during quality assurance analysis).
Inhalation: Move person to fresh air right away, loosen tight clothing, and provide oxygen if breathing seems difficult. Medical attention should be sought if symptoms persist or worsen.
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and mild soap for at least 15 minutes. Medical attention for irritation or blistering is necessary.
Eye Contact: Flush eyes gently and thoroughly with lukewarm water for at least 15 minutes, holding eyelids apart to ensure maximum exposure of eye tissue. Contact an eye specialist if irritation continues.
Ingestion: Do not induce vomiting. Rinse mouth with plenty of water and seek immediate medical attention. Keep the individual under observation for respiratory distress.
Suitable Extinguishing Media: Use dry chemical, foam, or carbon dioxide. Evacuate all non-essential personnel.
Specific Hazards Arising: Vapors may form explosive mixtures with air, may travel to ignition sources, and cause flashbacks. Emits toxic fumes upon burning, such as carbon monoxide and carbon dioxide.
Special Protective Equipment: Use self-contained breathing apparatus and full protective gear. Cool fire-exposed containers with water spray to prevent rupture.
Advice for Firefighters: Approach from upwind, keep unauthorized people away, and always remain outside explosion risk zones wherever possible.
Personal Precautions: Wear chemical-resistant gloves, eye protection, and positive pressure breathing apparatus. Remove all ignition sources in the spill area.
Environmental Precautions: Prevent release to sewers and waterways. Isolate area and contain spill using inert absorbent materials like sand or vermiculite.
Methods for Cleanup: Scoop up for disposal as chemical waste in sealed chemical containers. Dispose of contaminated absorbent in accordance with environmental laws and regulations. Adequate ventilation is a must during cleanup efforts.
Precautions for Safe Handling: Use only in well-ventilated areas or under fume extraction hoods. Employ spark-proof tools and explosion-proof electrical systems. Avoid direct contact with skin and eyes, and avoid inhalation of vapors.
Conditions for Safe Storage: Store away from oxidizers, acids, heat and open flames. Keep containers tightly closed in cool, dry, and well-ventilated places. The ideal storage temperature should not exceed 30°C (86°F). Separate from incompatible substances to prevent violent reactions.
Incompatibilities: Strong oxidizing agents, strong acids, bases, and reducing agents.
Exposure Limits: ACGIH TLV not established; local country specific limits may apply.
Engineering Controls: Employ proper local ventilation/extraction/air filtration. Fume hoods strongly recommended for laboratory work.
Personal Protective Equipment: Employees must wear chemical-resistant gloves such as nitrile or neoprene, safety goggles or a face shield, and impervious clothing. Respirators should be used if airborne concentrations exceed safe limits.
Hygiene Measures: Wash thoroughly after handling and before eating, drinking, or smoking. Remove and clean contaminated clothing prior to reuse.
Physical State: Liquid
Appearance: Clear, colorless to slightly yellow
Odor: Fruity, sweet, ester-like
Melting Point: -89°C
Boiling Point: 94–96°C
Flash Point: 14°C (Closed cup)
Autoignition Temperature: 446°C
Explosive Limits: Lower 1.3%, Upper 7.5% (v/v in air)
Vapor Pressure: 57 mmHg at 20°C
Solubility: Slightly soluble in water, readily miscible with organic solvents like ethanol and ether
Density: 0.871 g/cm³
Viscosity: Low; flows easily
Partition Coefficient: log Kow approximately 1.2
Chemical Stability: Stable under recommended storage conditions. Avoid high temperatures, static discharge, and unprotected exposure to light.
Possibility of Hazardous Reactions: Reacts vigorously with oxidizing agents, bases, and strong acids; may form peroxides under some conditions.
Conditions to Avoid: Heat, flames, sparks, static electricity, incompatible materials.
Hazardous Decomposition Products: Emits carbon monoxide and carbon dioxide gases when thermally decomposed.
Acute Toxicity: Oral LD50 (rat): 7630 mg/kg. Inhalation LC50 (rat): >5000 ppm/4hr. Low acute toxicity through skin absorption.
Symptoms of Exposure: Can cause dizziness, headaches, nausea, and mild respiratory irritation. Prolonged or repeated skin contact sometimes causes mild dermatitis.
Chronic Effects: No reports of carcinogenicity, mutagenicity, or reproductive toxicity from long-term exposure.
Routes of Exposure: Skin, eyes, inhalation, oral intake.
Target Organs: Central nervous system, mucous membranes of eyes and respiratory tract.
Ecotoxicity: Fish LC50 (96hr): 68 mg/L (Pimephales promelas). Daphnia LC50 (48hr): 136 mg/L. Not expected to be highly toxic in aquatic systems at levels below environmentally relevant concentrations.
Persistence and Degradability: Biodegradable in natural environments; breaks down through photolytic and microbial activity.
Bioaccumulative Potential: Low; low log Kow value.
Mobility in Soil: Moderately mobile due to solubility; may leach into groundwater if spilled in large amounts.
Other Adverse Effects: High vapor pressure contributes to atmospheric volatility. Not classified as an ozone-depleting substance under current regulations.
Waste Treatment Methods: Handle as hazardous chemical waste. Incinerate at facilities with proper emissions control. Absorb spills with suitable inert media before disposal.
Disposal Containers: Use containers approved for flammable liquids, with tight lids, labeled according to chemical contents.
Precautions: Use PPE during disposal procedures. Never pour unused product down drains, toilets or stormwater systems.
Local Regulations: Follow regional, national, and local regulations for waste material management.
UN Number: UN 3278
Proper Shipping Name: Methyl isobutyrate
Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Labels Required: Flammable liquid
Environmental Hazards: None classified
Special Precautions: Keep containers upright and tightly sealed during transit. Vehicle must be equipped for flammable cargo, drivers trained in handling hazardous materials.
Transport Notes: Follow IATA, IMDG, ADR requirements for land, air, and sea shipments respectively.
Inventory Status: Listed on TSCA, EINECS, DSL, AICS, ENCS, and other country inventories.
Safety Regulations: Covered by OSHA for workplace exposure, EPA for environmental release reporting (CERCLA), and SARA Title III for emergency planning.
Hazard Symbols: GHS02 (Flame), GHS07 (Exclamation Mark)
Chemical Safety Assessment: Assessment completed for workplace and environmental exposure. Recommended procedures for risk mitigation supplied in company risk management programs.
Other Standards: Compliance with REACH, Canadian WHMIS, Australian WorkSafe, and relevant transportation security regulations must be verified regularly by safety officers.
