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Methyl Dichloroacetate: Safety and Responsibility in the Lab

Identification

Chemical Name: Methyl Dichloroacetate
Synonyms: Methyl 2,2-dichloroacetate
Molecular Formula: C3H4Cl2O2
CAS Number: 116-26-7
Appearance: Clear, colorless liquid with a pungent, harsh odor
Uses: Primarily found in research environments for synthesis, not in consumer products

Hazard Identification

GHS Classification: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Signal Word: Warning
Potential Health Effects: Inhalation may trigger coughing, throat discomfort, or even headaches; skin contact can bring about redness or dryness; ingestion risks nausea, abdominal pain

Composition / Information on Ingredients

Component: Methyl Dichloroacetate – 100%

First Aid Measures

Inhalation: Remove person to fresh air. Seek medical help if symptoms worsen.
Skin Contact: Rinse with soap and plenty of water. Remove contaminated clothing.
Eye Contact: Flush cautiously with water for several minutes. Take out contact lenses.
Ingestion: Rinse mouth thoroughly. Do not induce vomiting. Get medical attention if feeling unwell.

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam
Hazardous Combustion Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Precautions for Firefighters: Wear full protective gear including a self-contained breathing apparatus since toxic fumes can release easily.

Accidental Release Measures

Personal Precautions: Use chemical-resistant gloves and goggles. Provide good ventilation.
Environmental Precautions: Prevent spillage from entering drains or waterways
Clean-up Methods: Contain and soak up spill with inert absorbent material like vermiculite. Collect in sealed container for proper disposal. Clean area thoroughly.

Handling and Storage

Handling: Work only in well-ventilated spaces. Avoid coming into direct contact with liquid or vapor. Always secure caps tightly after use.
Storage: Store in a cool, dry spot away from strong oxidizers, acids, and sources of heat or flame. Keep containers closed when not in use.

Exposure Controls and Personal Protection

Engineering Controls: Fume hood or local exhaust strongly recommended
Eye Protection: Chemical splash goggles
Skin Protection: Impermeable gloves, lab coat
Respiratory Protection: Use an approved respirator if exposure levels rise above comfort
Hygiene: Wash hands after handling. Avoid eating or drinking around the material.

Physical and Chemical Properties

Physical State: Liquid
Color: Colorless
Odor: Sharp, pungent
Boiling Point: Around 141°C (286°F)
Melting Point: Not widely reported
Solubility: Slightly soluble in water; mixes well in organic solvents
Vapor Pressure: Moderate at room temperature
Density: Near 1.4 g/cm³

Stability and Reactivity

Chemical Stability: Remains stable under recommended storage and handling
Incompatible Materials: Strong oxidizers, strong acids, bases, reducing agents
Hazardous Reactions: May emit hydrochloric acid and phosgene when exposed to fire or excessive heat

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Eye and skin redness, coughing, headache, possible stomach upset
Sensitization: Not commonly associated with allergic skin reactions
Chronic Exposure: Information is limited; long-term health studies do not exist in abundance for laboratory-scale exposures

Ecological Information

Aquatic Toxicity: Harmful to aquatic life due to persistence and poor biodegradability
Transport/Disposal Concerns: Should not be allowed to reach soil, sewers, or waterways
Persistence/Degradability: Not rapidly biodegradable

Disposal Considerations

Waste Treatment Methods: Dispose through a licensed facility specializing in hazardous chemical waste
Contaminated Packaging: Empty containers must be decontaminated before disposal; follow all local, regional, and national rules

Transport Information

UN Number: 2810 (Toxic liquid, organic, n.o.s.)
Shipping Name: Toxic liquid, organic, n.o.s.
Hazard Class: 6.1
Packing Group: III
Environmental Risks: Confirm transport adheres to local and international regulation due to aquatic harm

Regulatory Information

Global Inventory Status: Included in some chemical inventories, but not broadly registered for commercial use
Lab Safety: Handling and use typically fall under institutional chemical hygiene plans
Restrictions: Not approved for consumer or food applications; stays limited to qualified professional use