© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Chemical Name: 2,6-Dimethoxybenzoyl Chloride
Synonyms: 2,6-Dimethoxybenzoic acid chloride
CAS Number: 4136-95-2
Chemical Formula: C9H9ClO3
Appearance: White to off-white crystalline powder; distinct pungent odor
Use: Intermediate for pharmaceuticals and organic synthesis in laboratory settings.
Hazard Class: Corrosive to skin, eyes, and respiratory tract
GHS Label Elements: Skull and crossbones for toxicity; exclamation mark for irritation
Potential Health Effects: Causes severe burns on contact with skin or eyes; inhalation irritates respiratory system.
Chronic Effects: Prolonged exposure leads to dermatitis and respiratory difficulties.
Environmental Impact: Toxic to aquatic life if released in large quantities.
Main Ingredient: 2,6-Dimethoxybenzoyl Chloride (by weight, near purity for laboratory samples)
Impurities: Trace solvents or related acid chlorides from synthesis
Source: Derived from 2,6-dimethoxybenzoic acid and thionyl chloride in most lab scenarios.
Eye Contact: Rinse immediately with clean running water for at least fifteen minutes; keep eyelids apart.
Skin Contact: Remove contaminated clothing at once and wash affected area thoroughly with soap and water.
Inhalation: Move person to fresh air; seek medical attention for persistent coughing, shortness of breath, or burning.
Ingestion: Do not encourage vomiting; rinse mouth with water and consult a physician.
Symptoms: Redness, blistering, burning pain for skin and eyes; coughing, chest tightness for inhalation.
Suitable Extinguishing Methods: Use dry chemical, CO2, or alcohol-resistant foam. Water may spread corrosive fumes.
Hazardous Combustion Products: Releases hydrogen chloride, carbon monoxide, phosgene in a fire.
Precautions: Firefighters should wear full protective gear and self-contained breathing equipment.
Further Risks: Combustion causes the formation of highly corrosive, toxic byproducts; containment matters.
Personal Protection: Wear chemical splash goggles, gloves, and lab coat; ensure efficient room ventilation.
Spill Cleanup: Contain powder with absorbent; prevent dust formation. Collect into sealed container for proper disposal.
Environmental Precautions: Prevent runoff into waterways and drains.
Decontamination: Use dilute sodium bicarbonate to neutralize residual materials after cleanup—rinse surfaces thoroughly.
Incident Response: Stop source if safe; avoid all bodily exposure to spilled powder or vapors.
Handling Instructions: Work in a well-ventilated lab, fume hood if possible. Avoid all direct skin or eye contact.
Procedure Tips: Use airtight containers, minimize transfer operations, and never pipette by mouth.
Storage Requirements: Store in a tightly closed bottle, away from moisture and incompatible chemicals such as alcohols, bases, or amines.
Temperature: Room temperature is acceptable, but keep out of direct sunlight.
Cross-Contamination: Do not store with strong acids or oxidizers.
Personal Protective Equipment (PPE): Chemical-resistant gloves, splash goggles, lab coat, closed-toe shoes.
Engineering Controls: Use fume hood or local exhaust to control vapor and dust.
Hygiene Practices: Wash hands and exposed skin after handling—never eat or drink near working areas.
Exposure Limits: No established OSHA or ACGIH limits for this specific compound, treat as hazardous.
Respiratory Protection: Wear NIOSH-approved respirator if dust or fumes present.
Molecular Weight: 200.62 g/mol
Physical State: Solid, crystalline
Color: White to pale beige
Odor: Pungent and irritating
Melting Point: 63-65°C
Boiling Point: Decomposes before boiling
Solubility: Reacts with water, soluble in organic solvents such as dichloromethane, ether
Vapor Pressure: Low at room temperature
Reactivity with Water: Forms 2,6-dimethoxybenzoic acid and hydrochloric acid gas
Stability: Stable under tightly sealed, dry conditions away from sunlight.
Reactivity: Reacts vigorously with water, alcohols, bases, and amines, releasing heat and corrosive fumes.
Hazardous Decomposition: Produces hydrogen chloride gas, phosgene, and other toxic vapors in fire.
Polymerization: Does not polymerize under normal conditions.
Incompatibilities: Keep away from strong oxidizing agents, strong bases.
Acute Toxicity: Data on human toxicity is limited. Animal studies suggest significant irritation and moderate systemic toxicity with exposure.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion.
Symptoms: Burning of skin, tearing or burning sensation in eyes, respiratory irritation or chest pain, nausea if swallowed.
Chronic Effects: Repeated exposure may damage skin, lungs, or mucous membranes.
Carcinogenic Status: No established link to cancer by IARC, ACGIH, or OSHA; treat as hazardous based on structure and related compounds.
Persistence and Degradability: Reacts with moisture readily, forming acid byproducts.
Bioaccumulation: Low potential due to hydrolysis in aquatic environment.
Aquatic Toxicity: Corrosive action poses risk to aquatic organisms. Small spills react completely but large spills harm local wildlife.
Mobility: Limited mobility due to rapid breakdown after contact with water and soil.
Recommendations: Prevent discharge into lakes, streams, or public waste systems.
Waste Disposal: Place any remaining material or cleanup debris in sealed, labeled containers for hazardous waste collection.
Neutralization: Small amounts can be cautiously neutralized with dilute sodium bicarbonate under controlled conditions.
Regulatory Guidance: Follow all local, state, and national regulations for disposal of corrosive organic chemicals.
Special Handling: Never flush with water into drains or open environments.
Recycling: Unlikely due to toxicity and reactivity.
UN Number: Noted for hazardous delivery; normally handled as a Class 8 (corrosive) chemical for transport.
Packing Group: Appropriate packing required—avoid glass if potential for breakage and moisture exposure.
Labelling: Clearly display corrosive pictogram and hazard warnings on outer packaging.
Precautions: Store upright, protected from physical damage and water exposure during transport.
Restrictions: Many carriers restrict or require special documentation for acid chlorides such as this.
EU Regulation: Subject to REACH Annexes for industrial substances
US TSCA: Listed for research use; not broadly commercialized or registered for general sale.
Risk Phrases: Reference R34 (causes burns) and R37 (irritating to respiratory system) as standard European labeling.
SARA / CERCLA: Not a listed hazardous air pollutant or reportable quantity under US federal registers, but always consult current guidelines.
Workplace Control: Demands chemical hygiene plan for laboratory handling; regular staff training strongly advised.
