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Product Name: Methocarbamol
Chemical Name: 3-(2-Methoxyphenoxy)-1,2-propanediol carbamate
CAS Number: 532-03-6
Synonyms: Robaxin, Carbacot
Manufacturer: Listed by pharmaceutical companies and suppliers
Recommended Use: Muscle relaxant for treatment of musculoskeletal pain
Emergency Phone: Refer to local and national poison control centers; most suppliers also list their own 24-hour line
Classification: Not classified as hazardous according to GHS; always consider potential health impacts due to its pharmacological activity
Acute Effects: Drowsiness, dizziness, nausea, possible allergic reactions
Chronic Effects: Repeated exposure may affect liver and kidney function
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Hazard Symbols: Not considered hazardous under typical laboratory use, though avoid accidental overexposure
Signal Word: None assigned
Precautionary Statements: Prevent exposure by using proper personal protective equipment; do not inhale powder, minimize skin and eye contact
Chemical Identity: Methocarbamol
CAS Number: 532-03-6
Concentration: 100% for pure substance; blends in commercial tablets will have excipients and binders
Other Components: None in pure form; commercial products may contain fillers, coloring agents, and preservatives
Inhalation: Move to fresh air; keep airways open; seek medical attention if symptoms persist
Skin Contact: Wash immediately with plenty of water and mild soap; remove contaminated clothing; medical attention if irritation develops
Eye Contact: Flush with water for a minimum of 15 minutes; contact medical staff if discomfort continues
Ingestion: Rinse mouth, seek immediate medical advice—do not induce vomiting unless directed by medical personnel
Note to Physicians: Treat symptomatically and provide supportive care for overdose or accidental ingestion
Suitable Extinguishing Media: Water fog, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: High pressure water streams, due to possible dust dispersion
Specific Hazards: Methocarbamol is not highly flammable, but thermal decomposition may release toxic gases such as nitrogen oxides and carbon monoxide
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear to prevent inhaling toxic fumes
Firefighting Instructions: Control run-off, contain fires to minimize contamination to water supplies, avoid the use of respiratory irritant-producing methods
Personal Precautions: Wear gloves, laboratory coat, and safety goggles; avoid breathing dust or vapor
Environmental Precautions: Prevent entry into sewers or ground water systems; contain spilled product as much as possible
Cleanup Methods: Sweep up gently or vacuum using an approved filter; transfer to a closed, labeled container for disposal; wash spill area with plenty of water after removal
Disposal: Dispose of waste in compliance with local and national regulations; consult safety guidelines before flushing large quantities
Precautions for Safe Handling: Handle in well-ventilated areas; keep away from incompatible materials; do not eat, drink, or smoke while handling
Hygienic Practices: Wash hands thoroughly after handling; remove contaminated clothing and clean before reuse
Conditions for Storage: Store in a cool, dry, and well-ventilated location; protect from moisture, direct sunlight, and heat; keep container tightly closed
Storage Incompatibilities: Keep away from oxidizing agents and acids; do not store near food or animal feed
Exposure Limits: No established occupational exposure limits for methocarbamol in most regulatory jurisdictions; best practices recommend minimizing airborne concentrations
Engineering Controls: Use local exhaust ventilation or work in a chemical fume hood; monitor dust levels regularly
Personal Protective Equipment: Safety glasses, chemical resistant gloves (nitrile or neoprene), lab coat, respiratory protection where handling powder in bulk or if handling outside of a fume hood
Hygiene Measures: Avoid contact with skin, eyes, and clothing; do not ingest; always clean up spills immediately
Appearance: White or off-white crystalline powder
Odor: Odorless or very faint phenolic smell
pH: Slightly acidic to neutral in solution, typically between 5 and 7
Melting Point: 93 to 96°C (199 to 205°F)
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water (approximately 8 mg/mL), more soluble in methanol and ethanol
Density: About 1.2 g/cm³
Vapor Pressure: Negligible at ambient temperatures
Partition Coefficient (Log P): 1.3, indicating low to moderate potential for bioaccumulation
Chemical Stability: Stable under normal recommended storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, and direct sunlight; incompatible with strong oxidizers and acids
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Hazardous Polymerization: Will not occur under normal conditions
Reactivity: No dangerous reactions under recommended storage and handling guidelines
Acute Toxicity: Oral LD50 in rats: greater than 8,000 mg/kg (low acute toxicity)
Irritation: Possible mild skin and eye irritation with prolonged exposure
Sensitization: Rare instances of allergic reaction reported
Chronic Toxicity: At high or prolonged exposures in animals, possible liver or kidney impacts
Carcinogenicity: No evidence from animal or epidemiological studies of cancer risk
Reproductive Toxicity: No known reproductive hazards in humans documented for therapeutic doses
Mutagenicity: Tests have not shown methocarbamol to be genotoxic at therapeutic concentrations
Environmental Toxicity: Not expected to pose a significant hazard to aquatic or terrestrial environments at standard pharmaceutical use; very limited data on chronic exposures
Persistence and Degradability: Degradable under typical environmental conditions but can accumulate in water systems with persistent release
Bioaccumulation Potential: Low to moderate potential based on log P values
Mobility in Soil: Low, may bind to organic matter, limiting groundwater mobility
Other Effects: Do not release large quantities into waterways; prescription drugs in surface waters can affect aquatic organisms in sensitive ecosystems
Waste Disposal Methods: Incinerate at a licensed facility where possible; consult local authorities for best practice guidance
Container Handling: Rinse containers before disposal; puncture and dispose as regulated waste
Special Precautions: Never dispose to landfill, sewer, or the environment without regulatory approval; keep records of waste consignment for audit and compliance
UN Number: Not regulated for ground, air, or sea transport
Transport Hazard Class: Not classified as hazardous for transportation
Packing Group: Not applicable
Proper Shipping Name: Methocarbamol
Special Precautions: Avoid breakage of containers; keep away from strong oxidizers; observe standard pharmaceutical cargo security measures
EU Regulation: Not considered hazardous according to Regulation (EC) No 1272/2008 (CLP/GHS)
US Regulation: Not listed by OSHA as hazardous; not regulated under TSCA for pharmaceutical preparations
Canada: Not controlled under WHMIS, prescription status applies
SARA Title III: Not a hazardous substance under SARA 302/304/313
Other National Listings: Methocarbamol classified as prescription-only medicinal product by most regulatory agencies; always comply with national pharmacovigilance and controlled substance distribution requirements
