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Product Name: Methazolamide
Chemical Formula: C5H8N4O3S2
CAS Number: 554-57-4
Synonyms: N-(5-methyl-3,4-thiadiazol-2-yl)sulfamoylacetamide
Recommended Uses: Pharmaceutical agent, particularly for glaucoma
Supplier Information: Manufacturer or distributor details found on label
Emergency Contact: Poison control or medical emergency number
Classification: Harmful if swallowed, respiratory sensitizer, eye irritant
Signal Word: Warning
Hazard Statements: May cause serious eye irritation, may cause allergy or asthma symptoms or breathing difficulties
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use in ventilated environments
Symbols: Exclamation mark, health hazard pictograms
Potential Health Effects: Respiratory irritation, nausea, dizziness, headache, allergic reactions in sensitive individuals
Methazolamide: 99%–100%
Impurities: May contain trace process solvents or decomposition byproducts
Other Components: No significant non-active ingredients identified
Inhalation: Remove to fresh air immediately, keep individual at rest, seek medical attention if symptoms persist
Skin contact: Remove contaminated clothing, wash affected skin with water and soap, seek medical advice if irritation develops
Eye contact: Rinse thoroughly with clean water for at least fifteen minutes, remove contact lenses if present and easy to do, seek immediate medical attention
Ingestion: Rinse mouth, do not induce vomiting, provide water if conscious, obtain urgent medical attention
Special notes for providers: Symptomatic treatment as per clinical guidelines
Suitable Extinguishing Media: Water spray, carbon dioxide, powder extinguisher, foam
Unsuitable Extinguishing Media: Do not use direct high-pressure water streams
Hazardous Combustion Products: Sulfur oxides, nitrogen oxides, carbon oxides, toxic smoke
Firefighter Protection: Wear full protective gear and self-contained breathing apparatus, cool exposed containers with water spray
Explosion Hazards: Dust may form explosive mixtures with air in confined spaces
Personal Precautions: Use protective gloves and goggles, avoid breathing dust, ventilate area
Environmental Precautions: Prevent runoff into waterways, avoid soil contamination
Spill Cleanup: Sweep or scoop up material, use damp cloth or absorbent for residues, place collected waste in properly labeled containers
Disposal: Follow local regulations regarding disposal, do not release into drains
Handling: Handle in accordance with good industrial hygiene practices, avoid dust generation, use only in controlled environment
Storage: Keep container tightly closed, store in a cool, dry location, separate from incompatible substances such as strong acids and oxidizers
Safe Packaging: Use shatter-resistant, clearly labeled containers
Technical Precautions: Ensure storage area has proper ventilation
Exposure Limits: No OSHA or ACGIH exposure limits established for methazolamide
Engineering Controls: Local ventilation, fume hoods for bulk quantities
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, lab coat, NIOSH-approved dust mask where dust risk exists
Hygiene Measures: Wash hands thoroughly after handling, avoid eating or drinking near product
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: Approximately 210°C (decomposes)
Boiling Point: Not applicable
Solubility: Slightly soluble in ethanol and acetone, practically insoluble in water
Vapor Pressure: Not determined due to low volatility
Partition Coefficient (log P): Approximately -0.1
Density: 1.59 g/cm³
Flash Point: Data not available
Evaporation Rate: Not applicable
Explosive Properties: Dust can pose explosion risk in enclosed spaces
Chemical Stability: Stable under recommended conditions
Conditions to Avoid: Contact with strong oxidizing agents, acids, bases, elevated temperatures, open flames
Hazardous Decomposition: May release toxic gases (NOx, SOx, COx) during thermal decomposition
Reactivity: No polymerization expected under normal usage
Acute Toxicity: Oral LD50 in rats ~1200 mg/kg
Skin Irritation: Moderate irritation in experimental animals
Eye Irritation: Can cause severe irritation
Respiratory Sensitization: Experimental data suggest risk of sensitization after repeated inhalation
Chronic Effects: Case reports describe allergic reactions, kidney function changes with prolonged exposure in humans
Carcinogenicity: Not listed by IARC, NTP, OSHA as a carcinogen
Reproductive Toxicity: No conclusive animal or human data
Symptoms of Overexposure: Nausea, vomiting, dizziness, difficulty breathing, rash
Ecotoxicity: Minimal data, but pharmaceuticals can accumulate and affect aquatic organisms
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: Low, based on low partition coefficient
Mobility in Soil: Expected low due to poor water solubility
Other Adverse Effects: Release into waterways not recommended
Waste Treatment: Dispose according to national and local regulations
Incineration: Preferable method when large quantities handled, under controlled conditions
Unused Product: Avoid disposal in regular solid waste or drains
Container Handling: Rinse empty containers thoroughly before disposal or recycling
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Methazolamide
Transport Hazard Class: Not regulated under ADR, IMDG, IATA
Packing Group: Not assigned
Special Precautions: Secure packaging to prevent leaks or spills, keep away from incompatible materials
TSCA Status: Listed
REACH Status: Substance registration may be required in the EU
OSHA Status: Not regulated as a hazardous chemical
California Proposition 65: Methazolamide not listed
Other Regulations: Subject to drug and pharmaceutical control laws in some jurisdictions; always follow local, state, and national guidelines for handling, reporting, and disposal
