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Product Name: Methanesulfonic Anhydride
Chemical Formula: C2H6O5S2
Chemical Family: Sulfonic anhydrides
Synonyms: MS Anhydride, MSA Anhydride
Recommended Use: Chemical synthesis, industrial applications
Manufacturer/Supplier: Refer to company safety contacts
Emergency Phone: Refer to national poison centers
CAS Number: 1993-08-6
Hazard Classification: Corrosive to skin, eyes; may cause serious respiratory irritation
GHS Label Elements: Danger pictogram, signal word “Danger”
Hazard Statements: Causes severe skin burns and serious eye damage. May cause respiratory irritation.
Precautionary Statements: Avoid all direct contact. Avoid breathing vapors or dust. Wear proper protective clothing. Handle exclusively in a chemical fume hood.
Routes of Exposure: Inhalation, ingestion, contact with skin or eyes
Target Organs: Skin, eyes, respiratory system
Chemical Name: Methanesulfonic anhydride
Concentration: ≥98% by weight
Impurities: Trace sulfonic acids or water
Other Components: Non-applicable for this substance
Inhalation: Remove individual to fresh air without delay. Get medical attention if breathing is labored.
Skin Contact: Remove contaminated clothing at once. Wash affected area thoroughly with copious water for at least 15 minutes. Seek medical aid.
Eye Contact: Rinse with water for at least 15 minutes, spread eyelids apart to ensure thorough flushing. Emergency room assessment is needed.
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical help.
General Advice: Provide rescuers protection, avoid self-exposure, keep airways open, transport to healthcare facility without delay.
Flammability: Product is not considered flammable.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, or alcohol-resistant foam; avoid water streams that may cause violent reaction.
Specific Hazards: Generates toxic and corrosive fumes (SOx, carbon oxides, sulfonic acids) under combustion or high heat.
Protective Equipment for Firefighters: Self-contained breathing apparatus, chemical-protective clothing with gloves and boots.
Other Information: Keep containers cool with water spray. Leave scene to trained fire professionals if material is involved.
Personal Precautions: Evacuate area, keep away nonessential personnel, ventilate spill space.
Environmental Precautions: Prevent discharge into soil, waterways, drains. Minimize airborne spread.
Methods for Cleanup: Wear full PPE and respirator. Absorb with inert material such as sand or vermiculite. Transfer residues to chemical waste drums. Wash spill area thoroughly.
Decontamination: Neutralize small spills carefully with dilute alkali. Do not touch contaminated surfaces.
Waste Disposal: Collect all residues as hazardous waste according to local regulations.
Handling: Use only in fume hoods or areas with proper ventilation. Avoid all skin or eye contact. Prevent formation of aerosols or dust. Use anti-static equipment and grounding/protection from discharge.
Storage: Keep in tightly sealed, chemically resistant containers. Store in dry, cool, and well-ventilated area, away from bases, water, and oxidizers.
Incompatibilities: Strong bases, water, oxidizing agents, amines.
Special Handling Advice: Inspect storage areas for leaks regularly, post warning labels visibly.
Occupational Exposure Limits: Non-specific, treat as hazardous substance.
Engineering Controls: Local extraction ventilation required. Enclose critical processes. Use eyewash fountains and safety showers near chemical handling zones.
Personal Protective Equipment: Splash-resistant laboratory goggles, face shield, chemical-resistant gloves (nitrile or butyl rubber), flame-retardant laboratory coat, full-coverage shoes; use organic vapor respirator if ventilation is insufficient.
Hygiene Measures: Wash hands and face after handling. Do not eat, drink or smoke in work areas. Remove contaminated clothing prior to leaves or breaks.
Appearance: Clear, colorless to pale yellow liquid
Odor: Sharp or pungent, characteristic
Melting Point: Not well-defined, decomposes
Boiling Point: 161–162 °C at atmospheric pressure
Flash Point: Information not readily available
Autoignition Temperature: Not established
Solubility: Decomposes in water, soluble in organic solvents
Vapor Pressure: ~0.1 mmHg at 20 °C
Density: 1.63 g/cm³ at 20 °C
pH: Not applicable (reacts with water rapidly)
Partition Coefficient (log Pow): Data unavailable
Chemical Stability: Unstable with moisture, hydrolyzes in water
Instability Conditions: Exposure to air, humidity, strong bases
Materials to Avoid: Water, alcohols, strong bases, oxidizers, reducing agents
Hazardous Decomposition Products: Methanesulfonic acid, sulfur oxides, possible hazardous gases on contact with water or acids
Polymerization: Will not polymerize under standard storage conditions
Acute Toxicity: Highly corrosive to tissues; irritates respiratory tract and gastrointestinal system severely
Skin Corrosion/Irritation: Causes burns upon contact
Serious Eye Damage/Irritation: Severe tissue injury, possible blindness
Respiratory Effects: Burning, coughing, inflammation, possible pulmonary edema
Ingestion Effects: Severe gastrointestinal burns, risk of systemic toxicity
Chronic Exposure: Unclear mutagenic/carcinogenic data. Reliable toxicity reports limited.
Routes of Sensitization: No reliable evidence for sensitization.
Environmental Fate: Reacts rapidly with water forming methanesulfonic acid
Bioaccumulation Potential: Low, as hydrolysis occurs quickly
Aquatic Toxicity: Methanesulfonic acid, the hydrolysis product, is harmful to aquatic life at high concentrations
Mobility in Soil: High mobility due to acidic nature
Persistence/Degradability: Not persistent, but immediate environmental hazard if released
Product Disposal: Treat as hazardous chemical waste. Neutralize cautiously under fume extraction with suitable neutralizing agents. Transfer residues in tightly closed containers to licensed waste handler.
Contaminated Packaging: Clean thoroughly before recycling or incinerate as hazardous waste.
Legal Compliance: Follow all applicable federal, state, and local environmental regulations.
UN Number: 3265
Transport Hazard Class: 8 (Corrosive substances)
Packing Group: II or III, depending on concentration and volume
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (Methanesulfonic Anhydride)
Special Precautions: Transport in sealed and labeled corrosion-resistant drums or bottles. Avoid temperature extremes and moisture.
TSCA Status: Listed or complies with significant new use rule
REACH Registration: Covered by generic registration for sulfonic anhydrides in EU
SARA Title III (US): Not specifically listed, but reportable as hazardous due to corrosivity
Workplace Designations: Corrosive, hazardous; appropriate warning signage required; safety data sheet availability mandated by OSHA
Additional National/Regional Regulations: Subject to regulatory classifications for hazardous transport, storage, and usage under GHS, DOT, ADR, IMDG, IATA.
