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Product Name: Metacycline Hydrochloride
Synonyms: Methacycline Hydrochloride
CAS Number: 3963-97-9
Molecular Formula: C22H22N2O8·HCl
Recommended Use: Laboratory chemical, pharmaceutical intermediate
Supplier Details: Refer to manufacturer for local distribution
Emergency Contact: Controlled through regional Poison Control Centers
GHS Classification: Acute Toxicity (Oral) Category 4, Skin Irritation Category 2, Eye Damage Category 2A, Specific Target Organ Toxicity (Single Exposure) Category 3
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation or allergic reactions
Pictogram: Exclamation mark
Precautionary Statements: Avoid breathing dust, wear protection for hands, eyes, and skin, wash thoroughly after handling
Other Hazards: Not listed as carcinogenic by NTP, IARC, or OSHA; care needed to avoid generating dust.
Chemical Identity: Metacycline Hydrochloride
Concentration: ≥99%
Impurities: May contain trace levels of related tetracycline analogs, water, and mineral acids
EINECS Number: 223-546-0
Hazardous Components: Main hazard stems from the active compound
Inhalation: Remove from exposure area; move to fresh air immediately; seek medical attention if symptoms persist.
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical personnel; get medical help promptly.
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek attention for any skin irritation.
Eye Contact: Rinse immediately with gently flowing clean water for fifteen minutes; consult an ophthalmologist if irritation or pain persists.
Note to Physicians: Symptomatic treatment recommended; there is no specific antidote for this substance.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Hazardous Decomposition: Toxic gases including nitrogen oxides, hydrogen chloride, carbon oxides
Protective Equipment: Use self-contained breathing apparatus, full protective gear
Specific Hazards: Substance decomposes under intense heat; risk of exposure to hazardous fumes
Advice for Firefighters: Move containers from fire area only if it can be done safely; keep combustibles away from product; stay upwind
Personal Protection: Wear safety goggles, gloves, dust mask or respirator, chemical-resistant clothing
Spill Cleanup: Avoid generating dust, ventilate area, collect spilled material using non-sparking tools, sweep gently into disposal containers without water washdown
Decontamination: Wash spill site after material pick-up; prevent runoff into drains
Environmental Precautions: Prevent large releases to soil, drains, surface water, or groundwater; alert environmental authorities as required
Handling: Handle in well-ventilated location, avoid dust formation, do not ingest, do not inhale, prevent contact with skin and eyes; wash hands before eating, drinking, smoking; keep containers closed when not in use
Storage: Store away from light, moisture, incompatible chemicals, heat, ignition sources; keep between 2–8°C in tightly sealed, labeled container; segregate from strong oxidizers, acids, alkalis
Incompatible Materials: Strong oxidizing agents, strong acids and bases, sunlight
Occupational Exposure Limits: No established ACGIH or OSHA limits
Engineering Controls: Work in fume hood if available, use local exhaust; provide eyewash and safety shower
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, long-sleeved lab coat, NIOSH-approved N95 or similar if dust exposure probable
Hygienic Measures: Wash hands after handling; do not eat, drink, or smoke during use
Appearance: Pale yellow crystalline powder
Odor: Essentially odorless
Molecular Weight: 478.9 g/mol
Melting Point: 218–225°C (decomposes)
Solubility: Freely soluble in water, very slightly soluble in organic solvents
pH (1% Solution): 2.5–3.5
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible
Partition Coefficient: No data available
Flash Point: Non-flammable solid
Chemical Stability: Stable under recommended storage conditions; sensitive to light and moisture
Reactivity: Not highly reactive; forms salts with acids and bases
Hazardous Reactions: May react with strong oxidizers or strong acids
Decomposition Products: CO, CO2, nitrogen oxides, hydrogen chloride on combustion or decomposition
Conditions to Avoid: Strong light, humidity, high temperatures, incompatible materials
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Harmful if swallowed, causes skin/eye irritation
Chronic Effects: Prolonged or repeated exposure may cause allergic reactions, skin sensitization
LD50 (Oral, Rat): Estimated at 1700 mg/kg
Mutagenicity/Carcinogenicity: No evidence for mutagenic or carcinogenic effects in available studies
Target Organs: Possible effects on liver, kidneys, and hematopoietic system after significant exposures
Symptoms of Overexposure: Nausea, vomiting, diarrhea, respiratory symptoms, headache
Ecotoxicity: Avoid release to environment; may cause long-lasting adverse effects in aquatic settings
Persistence/Degradability: No robust biodegradation data; likely to persist in water, soil
Bioaccumulative Potential: Low expected due to compound size and solubility
Mobility in Soil: Likely mobile in aqueous environments because of high solubility
Other Environmental Hazards: Can negatively impact beneficial soil and aquatic microorganisms
Chronic Hazards: Risk of antimicrobial resistance in environmental bacteria with chronic exposures
Waste Treatment: Treat as hazardous laboratory waste; avoid discharge to sewers or waterways
Disposal Method: Incineration in approved commercial facility is preferred; consult national, state, and local environmental regulations
Contaminated Packaging: Rinse empty containers with water; dispose in accordance with institutional and regulatory policy
UN Number: Not regulated as a hazardous material for ground, air, or maritime transport
Proper Shipping Name: Metacycline Hydrochloride
Transport Hazard Class: Non-regulated for transport
Packing Group: Not applicable
Special Handling: Avoid extreme temperature, moisture, direct sunlight during transit
Environmental Precautions: Avoid container rupture; no bulk transport data
Global Inventories: Listed or exempted under most national chemical inventories; check for compliance in your jurisdiction
Regulated Material: Not listed under U.S. SARA Title III, CERCLA, or RCRA; check for national designations
Workplace Regulations: Observe U.S. OSHA, EU REACH, national worker safety laws; handle using proper lab protocols
Labeling: Follow GHS/OSHA hazard warning requirements; ensure secondary containers carry similar information
Restrictions: Not intended for food, cosmetic, or direct medical application outside of controlled pharmaceutical manufacturing settings
