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Product Name: Mesna
Chemical Name: Sodium 2-mercaptoethanesulfonate
Synonyms: Uromitexan, Sodium mesna
CAS Number: 19767-45-4
Manufacturer: [Insert Manufacturer Name]
Uses: Prevention of urothelial toxicity in chemotherapy
Contact Info: [Insert Emergency Contact Number, Address, Email]
Product Code: [Insert Product Code]
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Respiratory tract irritation, Specific target organ toxicity - single exposure (Category 3)
Pictograms: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, causes skin irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust or mist, wash thoroughly after handling, use in well-ventilated areas, wear protective gloves/eye protection/face protection
Potential Health Effects: Harmful if inhaled, ingested, or in contact with skin, can aggravate pre-existing respiratory conditions
Chemical Composition:
Mesna (Sodium 2-mercaptoethanesulfonate)
CAS Number: 19767-45-4
Concentration: 98-100%
Impurities: Trace levels of related compounds, sodium chloride possible as stabilizer
Molecular Formula: C2H5NaO3S2
Molecular Weight: 164.18 g/mol
Inhalation: Move person to fresh air, keep at rest in a comfortable position for breathing, seek medical attention for persistent symptoms
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing immediately, wash skin with plenty of soap and water, seek medical attention if irritation develops
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention as soon as possible
Note for Doctor: Treat symptomatically and provide general supportive measures; monitor for allergic reactions, especially in those with history of sulfur compound hypersensitivity
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Extinguishing Media: High volume water jet (could spread material)
Specific Hazards Arising: Combustion may yield sulfur oxides, sodium oxides, carbon oxides
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective clothing
Other Instructions: Remove containers from fire area if safe to do so, cool exposed containers with water
Additional Precautions: Avoid inhalation of decomposition products, prevent runoff into drains and water sources
Personal Precautions: Wear suitable protective equipment including gloves, goggles, face shield, and respirator
Environmental Precautions: Prevent entry into waterways, sewers, basements, or confined areas; notify authorities as needed
Clean Up Methods: Sweep up spilled material and place in suitable, labeled, closed containers for proper disposal; avoid dust formation; ventilate area; wash spill site after material pickup is complete
Decontamination: Use water and detergent to clean affected surface
Emergency Procedures: Restrict access to contaminated area until cleanup is complete
Safe Handling: Handle in a fume hood or well-ventilated environment; avoid contact with skin, eyes, and clothing; do not breathe dust or vapors
Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated place; keep away from incompatible substances such as strong oxidizers and acids
Storage Temperature: 15-25°C (59-77°F) recommended for long-term stability
Special Instructions: Keep container upright and away from moisture; protect from physical damage
Occupational Exposure Limits: Not established for Mesna; use general dust/mist exposure limits as guidance
Engineering Controls: Local exhaust ventilation, eyewash stations, and safety showers recommended near use area
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), splash goggles, lab coat, appropriate respiratory protection for dusts/mists
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling; do not eat, drink, or smoke during product use; launder contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Faint mercaptan (thiol) odor
Odor Threshold: Not established
pH: 7 to 8.5 for a 10% aqueous solution
Melting Point/Freezing Point: 167-168°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density: 1.41 g/cm³
Solubility: Soluble in water
Partition Coefficient (n-octanol/water): Not available
Auto-Ignition Temperature: Not Determined
Decomposition Temperature: >170°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Possible Hazardous Reactions: Contact with strong oxidizing agents may produce hazardous reactions; releases sulfur oxides under fire conditions
Conditions to Avoid: Excessive heat, exposure to moisture
Incompatible Materials: Strong acids, strong oxidizers, heavy metal salts
Hazardous Decomposition Products: Sulfur oxides, sodium oxides, carbon oxides
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): approximately 2900 mg/kg; low acute toxicity in animal studies
Skin Corrosion/Irritation: May cause skin irritation
Serious Eye Damage/Irritation: May cause eye irritation
Respiratory Sensitization: Data insufficient; potential for mild respiratory irritation
Skin Sensitization: Not considered a skin sensitizer
Chronic Toxicity: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in animal models
Other Data: Can cause gastrointestinal upset if swallowed; excessive exposure can aggravate asthma-like symptoms
Ecotoxicity: Low aquatic toxicity expected; not anticipated to bioaccumulate
Persistence and Degradability: Rapidly biodegradable in water and soil environments
Bioaccumulative Potential: Low (log Kow < 1)
Mobility in Soil: High mobility due to water solubility
Other Adverse Effects: No data on long-term environmental effects; avoid release to environment to minimize burden on aquatic and terrestrial organisms
Waste Disposal Methods: Dispose of waste material in accordance with local, regional, and national regulations; incineration or landfill permitted for non-hazardous pharmaceutical waste
Container Handling: Rinse containers thoroughly before disposal; do not reuse packaging for other materials
Environmental Precautions: Prevent product from entering drains, waterways, or environment
UN Number for Waste (if applicable): Not regulated as hazardous waste
UN Number: Not regulated as a dangerous good
Proper Shipping Name: Not classified
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Marine Pollutant: Not identified as a marine pollutant
Special Transport Precautions: Keep containers tightly sealed, within temperature ranges, and protected from moisture during transit
Safety, Health, and Environmental Regulations: Mesna is registered for medical uses and is not classified as a hazardous substance under most national and international chemical safety legislation
TSCA (USA): Listed
EINECS (EU): Listed
REACH (EU): Not classified as dangerous under regulation; registration/notification may apply
OSHA Hazards: Skin and eye irritant
WHMIS (Canada): Not controlled product
Other Regulations: Users must comply with all applicable local, national, and international regulations for handling and use; professional training recommended for workplace use of the substance
