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Product Name: Mequitazine
Synonyms: 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)phenothiazine, Allerzil
Chemical Formula: C20H22N2S
CAS Number: 29216-28-2
Recommended Use: Antihistamine for allergies
Manufacturer: Pharmaceutical companies, listed in regulatory submissions
Contact Information: Refer to the supplier on the official product label for emergency support and technical details
Classification: Acute toxicity (oral, category 4); Eye irritation (category 2A); Specific target organ toxicity (single exposure, category 3)
GHS Label Elements: Warning symbol, hazard statement codes H302 (harmful if swallowed); H319 (causes serious eye irritation); H335 (may cause respiratory irritation)
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Hazard Statements: Respiratory tract and eye irritation, possible CNS effects such as drowsiness or confusion, possible allergic reactions if mishandled
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use with proper ventilation
Chemical Name: Mequitazine
Purity: ≥98% (depending on supplier and batch)
Other Ingredients: In pure bulk material, only Mequitazine; in formulated dosage, includes excipients (lactose, cellulose, magnesium stearate, etc.)
Impurities: Pharmaceutical-grade batches meet ICH impurity guidelines, less than 0.1% individual unknowns
Stability Agents: None added to the pure substance
Inhalation: Remove from exposure site, bring to fresh air, seek medical attention if symptoms like coughing, dizziness, or headache persist
Skin Contact: Wash affected skin with soap and water for at least 15 minutes, remove contaminated clothing, get medical advice if irritation or symptoms develop
Eye Contact: Rinse eyes immediately with plenty of water for a minimum of 15 minutes, lifting upper and lower eyelids occasionally, seek immediate medical attention
Ingestion: Rinse mouth, seek medical attention immediately, do not induce vomiting without instructions from medical professionals
Most Important Symptoms / Effects: Respiratory distress, central nervous system depression, eye or skin irritation, severe allergic responses possible in rare cases
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Special Hazards: Thermal decomposition releases toxic fumes such as nitrogen oxides, sulfur oxides, and carbon monoxide
Protective Equipment: Firefighters should wear self-contained breathing apparatus and fully protective gear to avoid exposure to smoke and dust
Explosion Risk: The material in fine powder can pose a dust explosion hazard under strong ignition conditions
Specific Fire Procedures: Move containers away from fire area if it can be done safely, cool containers with water spray to prevent pressure build-up
Personal Precautions: Use proper personal protective equipment to avoid skin and respiratory contact; avoid generating dust; ventilate area well
Environmental Precautions: Prevent further leakage or spillage if safe to do so; avoid contamination of soil, drains, and water sources
Clean-Up Methods: Carefully sweep up and collect spilled material, store in labeled, closed containers for disposal according to local regulations; rinse area with detergent and water
Emergency Procedures: Notify safety personnel, isolate the area, and restrict access to only trained responders
Handling: Handle in a chemical fume hood or well-ventilated area; keep container tightly closed; avoid breathing dust, and prevent contact with skin, eyes, and clothing; proper training and procedures reduce risk
Storage: Store in the original, labeled container at 15–30°C, away from light, moisture, strong acids and oxidizers; store in a cool, dry, locked facility with limited access
Incompatibilities: Avoid storing near strong acids, bases, and oxidizing agents
Control Parameters: No established OSHA, NIOSH, or ACGIH exposure limits, use internal limits based on risk assessment and occupational exposure bands
Engineering Controls: Use chemical fume hoods for dispensing and weighing, local exhaust ventilation to minimize airborne concentrations
Personal Protection: Wear safety goggles, nitrile or latex gloves, long-sleeved lab coats or coveralls, closed-toe shoes; use suitable respiratory protection if dust concentration increases
Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink in work area, remove contaminated clothing and clean before reuse
Appearance: White or pale yellow crystalline powder
Odor: Odorless or slight amine smell
Melting Point: 106–108°C
Solubility: Practically insoluble in water, freely soluble in acetone, ethanol, methanol
pH (1% solution): 4–6 (in methanol-water mixture)
Boiling Point: Decomposes before boiling
Vapor Pressure: Not meaningful at room temperature
Relative Density: About 1.13 g/cm³
Partition Coefficient (log Kow): Approx. 3.5–4.0
Flash Point: Not applicable (decomposes)
Auto-ignition Temperature: Not established
Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not reactive with common materials under ambient conditions
Hazardous Reactions: No dangerous reactions known under normal process use; avoid sources of ignition and incompatible substances
Decomposition Products: Produces toxic gases such as nitrogen oxides, carbon monoxide, and sulfur oxides when heated to decomposition
Polymerization: Will not occur under standard storage and use
Acute Toxicity: Oral LD50 in rats estimated at 350 mg/kg; potentially toxic if ingested by humans, with symptoms such as drowsiness, confusion, dry mouth, blurred vision, and tachycardia reported
Chronic Effects: Long-term exposure linked to anticholinergic side effects, possible cardiac arrhythmias
Skin and Eye Contact: May cause irritation, redness, and pain; repeated exposure can worsen symptoms
Sensitization: Reports of allergic contact dermatitis in sensitized individuals
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogenic, mutagenic, or toxic to reproduction in standard regulatory listings
Other Information: Medical professionals should monitor for central nervous system or cardiovascular symptoms in case of overdose
Ecotoxicity: Limited data; possible harmful effects on aquatic organisms based on chemical class, recommend avoiding contamination of surface water
Persistence and Degradability: Not readily biodegradable, persistent in the environment over time, slow breakdown in soil or water
Bioaccumulation: Moderate potential for bioaccumulation due to log Kow above 3
Mobility in Soil: Limited mobility because of poor water solubility, may bind to organic matter
Other Adverse Effects: Pharmaceutical residues potentially disrupt aquatic invertebrates; disposal and wastewater protocols recommended
Waste Disposal: Dispose as hazardous pharmaceutical waste according to state and national regulations; incinerate in an approved facility
Container Disposal: Triple-rinse and destroy empty containers; ensure labels are removed and containers are not re-used for other purposes
Contaminated Packaging: Treat as chemical waste and follow site-specific disposal instructions
Special Precautions: Do not dispose of via sinks, drains, or municipal waste streams; consult waste contractor or regulatory agency for guidance
UN Number: Not assigned for Mequitazine
UN Proper Shipping Name: Not regulated as a dangerous good for ground, air, or maritime transport
Transport Hazard Class: Not hazardous under transport regulations
Packing Group: Not assigned
Special Precautions: Ship with secure, leak-proof packaging; include proper labeling when sending with commercial couriers; follow company SOPs for pharmaceutical compounds
Safety, Health, and Environmental Regulations: Substance not listed in Annex I of EC Dangerous Substances Directive; not on US TSCA inventory; regulated as a prescription pharmaceutical in most countries
Workplace Regulations: Handle according to standard operating procedures for potent pharmaceuticals; use personal protective equipment; training required for handlers
Other Compliance: Follows GHS labeling where applicable; meet requirements set by local drug and chemical safety agencies; ensure compliance with waste management regulations
SDS Revision Date: Provided on official document from supplier/manufacturer
