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Product Name: Menatetrenone
Synonyms: Vitamin K2, Menaquinone-4
Chemical Formula: C31H40O2
CAS Number: 863-61-6
Recommended Use: Active pharmaceutical ingredient, dietary supplement ingredient
Supplier Contact: Available from manufacturer upon request
Emergency Phone: Refer to local regulations or supplier details
GHS Classification: Not classified as hazardous under GHS
Signal Word: None
Hazard Statements: May cause mild eye or skin irritation upon prolonged contact
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling
Potential Health Effects: Low toxicity, may act as mild irritant
Environmental Hazards: Potential hazard for aquatic environments if released in significant amounts
Chemical Name: Menatetrenone
Common Names: Vitamin K2-4, Menaquinone-4
Concentration: ≥ 98%, depending on manufacturer
Impurities: May contain residual solvents or process impurities at trace levels
Other Components: None identified at significant concentration
Inhalation: Move to fresh air, seek medical attention if respiratory symptoms occur
Skin Contact: Remove contaminated clothing, wash skin with soap and water
Eye Contact: Rinse immediately with water for at least 15 minutes, remove contact lenses if present
Ingestion: Rinse mouth with water, seek medical advice if large quantities are swallowed
Notes to Physician: Treat symptomatically, no specific antidote known
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam
Unsuitable Extinguishing Media: Direct water stream may spread fire
Hazardous Combustion Products: May release carbon oxides, irritating fumes and smoke
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Special Precautions: Prevent runoff from entering drains or watercourses
Personal Precautions: Wear gloves, chemical safety goggles, and protective clothing
Environmental Precautions: Prevent material from reaching waterways, sewers, or soil
Containment: Use inert absorbent material to prevent spread of dust
Cleaning Methods: Sweep up material without raising dust, transfer to a labeled container for proper disposal
Disposal: Dispose of collected material according to local regulations
Safe Handling Practices: Minimize dust generation, avoid contact with skin, eyes, and clothing
Hygiene Measures: Wash hands after handling, do not eat or drink near product\n\
Technical Measures: Use adequate ventilation or local exhaust
Storage Conditions: Store in cool, dry, well-ventilated area away from direct sunlight and incompatible substances
Incompatibilities: Oxidizing agents, strong acids or bases could react with product
Specific Storage Requirements: Store in tightly sealed container
Exposure Limits: No occupational exposure limits established for Menatetrenone
Engineering Controls: Use local exhaust ventilation or general room ventilation
Personal Respiratory Protection: Use dust mask if dust formation is possible
Eye Protection: Chemical splash-proof safety goggles
Skin Protection: Nitrile or other chemical-resistant gloves
Body Protection: Lab coat or equivalent protective clothing
Environmental Controls: Prevent release to environment, use process enclosures or waste containment as needed
Appearance: Yellow to orange crystalline powder
Odor: Mild or odorless
Odor Threshold: Not established
pH: Not applicable (insoluble in water)
Melting Point / Freezing Point: 53–56°C
Boiling Point: Not determined (decomposes before boiling)
Flash Point: >110°C (closed cup estimate)
Evaporation Rate: Not applicable
Flammability: May be combustible as an organic solid
Vapor Pressure: Negligible
Vapor Density: No data
Relative Density: 0.97–1.04 g/cm3
Solubility in Water: Insoluble
Solubility in Solvents: Soluble in chloroform, ether, and vegetable oils
Partition Coefficient (n-octanol/water): logP ~ 8.5
Auto-Ignition Temperature: Not determined
Decomposition Temperature: >90°C
Viscosity: Not applicable
Chemical Stability: Stable under normal conditions, sensitive to light, heat, and air exposure
Reactivity: No known dangerous reactions under normal storage and use
Conditions to Avoid: High temperatures, exposure to sunlight, humidity
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Produces carbon monoxide, carbon dioxide, possible toxic fumes if heated to decomposition
Polymerization: Product does not polymerize
Acute Toxicity: Oral LD50 in rats estimated >5000 mg/kg, low risk of acute poisoning
Chronic Toxicity: No evidence of significant toxicity after long-term exposure at normal use concentrations
Skin Corrosion/Irritation: Non-corrosive, mild irritant on contact
Serious Eye Damage/Irritation: Possible mild irritation
Sensitization: No known sensitizing effects
Germ Cell Mutagenicity: No mutagenic effect identified in standard assays
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Reproductive Toxicity: No evidence of harm to fertility or unborn child based on available animal studies
STOT – Single Exposure: No effects anticipated at occupational levels
STOT – Repeated Exposure: No target organ toxicity at anticipated exposures
Other Information: Persons with known hypersensitivity to menadione derivatives should avoid contact
Aquatic Toxicity: No acute aquatic toxicity data available, suspected low toxicity based on structure and solubility
Persistence and Degradability: Readily biodegradable in soil and water under aerobic conditions
Bioaccumulative Potential: High logP may suggest potential to bioaccumulate in aquatic organisms
Mobility in Soil: Limited mobility, strong affinity for solid phase
Other Adverse Effects: No significant ozone depleting potential, negligible photochemical reactivity
Precautions: Avoid uncontrolled release to surface waters, minimize environmental exposure
Waste Treatment Methods: Dispose of product in accordance with local, regional, and national regulations
Product Disposal: Incinerate or landfill only as allowed by regulations, do not discharge to drains or water bodies
Packaging Disposal: Rinse empty containers, dispose or recycle according to local waste management regulations
Special Instructions: Consider consulting hazardous waste disposal contractor for large quantities
Contaminated Packaging: Treat as hazardous waste if product residue remains
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class(es): None
Packing Group: None
Environmental Hazards: Not classified as marine pollutant
Special Precautions: Avoid exposure to direct sunlight or moisture during transport
Segregation Requirements: Separate from oxidizing agents and foodstuffs
Occupational Safety: Not subject to specific OSHA occupational exposure standards
TSCA Status: Listed or excluded from control
REACH Status: Exempt or registered depending on intended use in Europe
International Inventories: Product may appear under different identifiers in chemical inventories in the US, EU, Japan, and elsewhere
Labeling Requirements: Not required under GHS for non-hazardous chemicals, observe general laboratory safety labeling
Other Regulations: Use in foods and supplements regulated under FDA or national equivalents, adhere to maximum permitted levels
SARA Title III: No Section 302 EHS, no Section 313 chemicals
California Proposition 65: Not listed
