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Product Name: Meloxicam
Chemical Name: 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
CAS Number: 71125-38-7
Intended Use: Pharmaceutical ingredient, veterinary applications
Manufacturer Information: Supplied by various pharmaceutical firms, information available from batch-specific documentation
Emergency Contact: Consult local poison control center or emergency services
Hazard Classification: Not classified as hazardous under GHS for solid product
Acute Effects: May cause irritation to eyes, skin, and respiratory tract upon contact
Chronic Effects: Long-term exposure can induce gastrointestinal discomfort, headache, or dizziness
Signal Word: Warning
Hazard Statements: Causes mild skin and eye irritation; harmful if ingested in large quantities
Symptoms of Overexposure: Nausea, vomiting, abdominal pain, signs of hypersensitivity
Precautionary Statements: Use with adequate ventilation, avoid prolonged exposure, wash hands after handling
Chemical Name: Meloxicam
CAS Number: 71125-38-7
Molecular Formula: C14H13N3O4S2
Concentration: 100% pure solid in bulk form, or as per label for mixtures
Impurities/Additives: Trace synthesis byproducts may be present at very low levels, not expected to influence hazards
Inhalation: Remove to fresh air, seek medical attention if respiratory irritation develops or persists
Skin Contact: Wash affected area with soap and water, remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, consult a physician
Ingestion: Do not induce vomiting, rinse mouth thoroughly, contact medical assistance promptly
Important Symptoms: Redness, itching, burning, nausea, or headache
Note for Physicians: Symptomatic treatment as required, monitor for gastrointestinal distress or allergic reaction
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: Avoid high-pressure water streams that may spread powder
Special Hazards: Combustion generates hazardous decomposition products like carbon monoxide, nitrogen oxides, sulfur oxides
Protective Equipment: Self-contained breathing apparatus, full protective clothing for fire fighters
Explosion Data: Dust may form explosive mixture with air in rare cases; handle powders carefully
Personal Precautions: Prevent dust formation, use personal protective equipment including gloves and masks
Environmental Precautions: Prevent from entering drains, surface water, or soil
Cleanup Methods: Sweep up without raising dust, place in closed containers for disposal according to regulations
Decontamination: Wash spill area thoroughly with water once organic matter removed
Reporting Requirements: Notify authorities if environmental release threatens public water or safety
Handling: Use with proper ventilation, minimize dust generation and accumulation, wash hands thoroughly before breaks and at end of shift
Hygiene Measures: Avoid eating, drinking, or smoking when using product, wear suitable gloves and clothing
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated place, away from incompatible chemicals
Packaging Materials: Use containers made of non-reactive, sealed material to prevent contamination or deterioration
Storage Temperature: Keep between 15–30°C, protect from moisture
Engineering Controls: Use process enclosures, local exhaust ventilation, eye wash stations and safety showers
Personal Protective Equipment: Protective gloves, safety goggles, lab coat, respiratory protection if dust is generated
Occupational Exposure Limits: No established OSHA or ACGIH limits; handle as a pharmaceutical active substance
Environmental Controls: Prevent uncontrolled environmental release, use filters and containment during processing
Appearance: Light yellow crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: Slightly acidic to neutral (around pH 5.5–7 in suspension)
Melting Point: 255–263 °C
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined
Evaporation Rate: Not applicable (solid)
Flammability: Not highly flammable; dust may pose minor risk
Vapor Pressure: Negligible
Solubility: Practically insoluble in water; soluble in DMSO, slightly soluble in methanol
Partition Coefficient (log Kow): 2.22
Relative Density: ~1.6 g/cm3
Vapor Density: Not applicable
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 255°C
Viscosity: Not applicable
Reactivity: Does not react under standard conditions
Chemical Stability: Stable at room temperature in dry, closed containers
Conditions to Avoid: Heat, humidity, strong light
Incompatible Materials: Strong oxidizers, strong bases
Hazardous Decomposition Products: Thermal decomposition yields carbon monoxide, sulfur oxides, and nitrogen oxides
Polymerization: Does not occur under normal handling
Acute Toxicity: LD50 oral (rat): >200 mg/kg; lower for smaller animals
Skin Corrosion/Irritation: Slight irritant to skin based on animal studies
Eye Damage/Irritation: Can cause mild transient eye irritation
Respiratory Sensitization: May cause mild respiratory irritation with repeated exposure to dust
Germ Cell Mutagenicity: No evidence in standard tests
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: Possible risk of harm to unborn child at high, chronic exposures (animal models)
STOT — Single Exposure: May cause drowsiness, headache, digestive upset
STOT — Repeated Exposure: Chronic ingestion may affect liver, kidney, or gastrointestinal tract
Aspiration Hazard: Not expected due to physical form
Ecotoxicity: Toxic to aquatic organisms at high concentrations; low potential for bioaccumulation
Persistence/Degradability: Degrades slowly in soil and water; photodegradation possible
Mobility in Soil: Low mobility due to poor water solubility
Bioaccumulative Potential: Not expected to accumulate significantly based on log Kow
Other Adverse Effects: Long-term large-scale release may disrupt aquatic environments, residues not recommended for disposal in natural waterways
Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations, preferably by incineration in approved facility
Contaminated Packaging: Empty containers should be triple rinsed and given to an approved waste handler
Special Precautions: Avoid large-scale disposal in landfill or sewage, prevent environmental contamination
UN Number: Not regulated for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not classified as hazardous for transport
Packing Group: Not applicable
Environmental Hazards: None identified during normal transport
Special Precautions: Handle as a pharmaceutical product, use secure packaging to prevent exposure in case of accidental spillage
U.S. Regulations: Not subject to TSCA; for pharmaceutical use only, subject to FDA requirements
EU Regulations: Registered under REACH as a pharmaceutical intermediate, not classified as hazardous
Other International Regulations: Subject to prescription and veterinary drug laws in many jurisdictions
Labeling Requirements: Pharmaceutical packaging includes standard warning and hazard statements as required by local regulations
Occupational Health: Recommendations and safe work practices guided by institutional control measures and workplace safety policies
