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Product Name: Melatonin
Chemical Name: N-Acetyl-5-methoxytryptamine
Synonyms: Pineal hormone, MEL, Circadin
CAS Number: 73-31-4
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28 g/mol
Recommended Use: Dietary supplement, sleep aid, research
Supplier Information: Refer to manufacturer identity on labeling or shipment documentation
Emergency Contact: Refer to local poison control or manufacturer-provided emergency number for technical support
GHS Classification: Not classified as hazardous for supply under GHS
Potential Health Effects: May cause mild eye and skin irritation, avoid inhalation and ingestion in large quantities
Physical Hazards: Not flammable or explosive in supplied form
Label Elements: No pictograms or hazard statements required according to standard labelling criteria
Precautionary Statements: Avoid contact with eyes, prolonged skin contact, ingestion of large doses, and inhalation of powder
Target Organ Effects: Central nervous system (high dosages), minor gastrointestinal effects
Chemical Identity: Melatonin
Purity: Typically ≥98% pure
Other Ingredients: None for pure substance
Impurities: Trace solvents possible, batch dependent (details provided by manufacturer COA)
Inhalation: Remove from exposure, get fresh air, seek medical attention for persistent irritation
Skin Contact: Wash affected area with plenty of soap and water; seek medical care for persistent skin irritation or rash
Eye Contact: Immediately flush eyes with water for several minutes, lifting upper and lower lids; remove contact lenses if present and easy to do; seek medical attention if discomfort continues
Ingestion: Rinse mouth with water if small amounts consumed; consult healthcare provider if discomfort, nausea, or large amounts consumed
Most Important Symptoms: Irritation, headache, drowsiness if overdosed
Advice for Physicians: Symptomatic and supportive care required; treat based on clinical symptoms
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: May emit hazardous fumes such as carbon oxides, nitrogen oxides, and smoke if subjected to excessive heat or fire
Protective Equipment: Wear self-contained breathing apparatus and full protective gear during firefighting efforts
Advice for Firefighters: Prevent runoff from entering water systems; decontaminate firefighting gear after use
Explosion Data: Dust clouds at high concentrations may present a risk, use ventilation to minimize
Personal Precautions: Use personal protective equipment such as gloves, protective eyewear, and dust mask
Environmental Precautions: Prevent large quantities from entering waterways and drains
Cleanup Methods: Sweep up spilled material with care to avoid dust formation; collect for proper disposal; ventilate area if dust is produced
Decontamination: Wipe surfaces with damp cloth, dispose of waste according to local regulations
Safe Handling: Avoid dust production, use appropriate ventilation; do not eat, drink, or smoke during handling
Personal Hygiene: Wash hands thoroughly after handling
Storage Conditions: Store sealed container in a cool, dry, and well-ventilated area; keep away from incompatible substances such as oxidizing agents
Shelf Life: Typically stable for several years under recommended conditions
Storage Temperature: 2–8°C preferred, protect from direct sunlight and moisture
Control Parameters: No official occupational exposure limits set for melatonin; limit airborne dust as much as possible
Engineering Controls: Use laboratory hoods or local exhaust to minimize exposure, especially for weighing or powder transfer
Eye Protection: Safety goggles recommended
Skin Protection: Gloves and lab coat to prevent skin contact
Respiratory Protection: Dust mask or respirator for significant dust exposure
General Hygiene: Do not eat, drink, or smoke in work area; wash hands before breaks and after work
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined in water
Melting Point: 116–118°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Flammability: Not flammable
Vapor Pressure: Negligible
Specific Gravity: 1.175
Solubility: Slightly soluble in water, soluble in ethanol, DMSO
Partition Coefficient (log Kow): 1.2
Decomposition Temperature: Above 200°C
Other Properties: Stable under normal conditions; light sensitive
Chemical Stability: Stable under normal laboratory and storage conditions
Incompatibilities: Strong oxidizers, strong acids
Decomposition Products: Emits carbon oxides and nitrogen oxides under fire conditions
Conditions to Avoid: Direct sunlight, moisture, high temperatures
Hazardous Reactions: No dangerous reactions known under normal use
Acute Toxicity: Oral LD50 in rats greater than 1200 mg/kg (low toxicity)
POTENTIAL HEALTH EFFECTS: May cause mild eye and skin irritation; large doses by mouth may produce sleepiness, headache, gastrointestinal upset
Chronic Effects: No evidence of carcinogenicity or long-term toxicity in standard tests
Sensitization: Not classified as a sensitizer
Mutagenicity: Not genotoxic in standard laboratory tests
Reproductive Effects: No reported adverse reproductive effects at usual human doses
Ecotoxicity: Not expected to pose significant ecological hazard at normal environmental levels
Persistence and Degradability: Biodegradable in soil and water
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: Low; substance binds to organic matter
Aquatic Toxicity: No significant aquatic toxicity found at expected concentrations
Other Adverse Effects: Not classified as PBT or vPvB; spills should be contained to prevent unnecessary release
Waste Disposal Methods: Dispose of in compliance with local, regional, and national regulations
Contaminated Packaging: Triple rinse and follow hazardous waste protocols if contaminated
Special Considerations: Do not dispose of large quantities in general waste; consult licensed waste disposal service for bulk material
Incineration: Recommended for significant amounts of material
UN Number: Not regulated for transport
Proper Shipping Name: Not restricted
Transport Hazard Class: None
Packing Group: None
Environmental Hazards: Not a marine pollutant
Special Precautions: Protect from physical damage, moisture, and direct sunlight during transit
Additional Information: Material is stable and poses minimal transport risk
Health and Safety Regulations: No specific workplace exposure limits; classified as non-hazardous per OSHA and EU CLP
Inventory Listings: Listed on TSCA, EINECS, DSL, AICS
REACH Status: Not subject to registration in typical quantities used
Labeling Requirements: Standard labeling with product name, purity, and supplier information
Other Regulatory Standards: Not listed as hazardous under US SARA, California Prop 65, or RoHS
Export/Import Restrictions: None for standard research or supplement use
