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Product Name: Mebhydrolin Naphthalenedisulfonate
Other Names: Mebhydrolin, Histafax
Chemical Formula: C20H22N2O6S2
CAS Number: 91-67-8
Intended Use: Antihistamine agent for pharmaceutical formulations
Manufacturer: Contact supplier or pharmaceutical manufacturer for facility and address
Emergency Contact: Refer to local poison control center or manufacturer's emergency hotline
GHS Classification: Acute Oral Toxicity Category 4, Eye Irritation Category 2A, Skin Sensitizer Category 1
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause allergic skin reaction
Pictograms: Exclamation mark
Precautionary Statements: Do not breathe dust or powder, wash thoroughly after handling, wear protective gloves and eye protection
Routes of Exposure: Inhalation, skin, eye contact, ingestion
Acute Effects: Nausea, vomiting, headache, skin rash, eye irritation, respiratory discomfort
Chemical Name: Mebhydrolin Naphthalenedisulfonate
Concentration: ≥98% by weight
Impurities: ≤2% unspecified related compounds
Additives/Stabilizers: No significant additives present under normal storage conditions
Inhalation: Move affected person to fresh air, keep at rest, monitor breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water for at least 15 minutes, call a doctor if irritation develops
Eye Contact: Rinse gently with running water for several minutes, remove contact lenses if possible, seek medical care if redness or pain continues
Ingestion: Rinse mouth, never provide fluids or induce vomiting in an unconscious person, get medical help
Note to Physician: Treat symptomatically, monitor for allergic reactions and respiratory distress
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Extinguishing Media: High-pressure water jets can scatter powdered material
Hazardous Combustion Products: Sulfur oxides, carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Fire/Explosion Hazards: Product can burn under fire conditions, dust may form explosive atmosphere if dispersed in air
Firefighting Instructions: Move containers away from fire area if safe, prevent runoff from entering drains, cool containers with water spray
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear suitable personal protective equipment including dust mask, gloves, safety goggles, laboratory coat
Spill/Leak Procedures: Avoid production of dust, sweep up or vacuum without raising dust, transfer to designated chemical waste container
Environmental Precautions: Prevent spills from entering drains, soil, waterways
Clean-Up Methods: Wash spill area with soap and water after material pickup, use non-sparking tools
Safe Handling Advice: Avoid inhalation, ingestion, skin, and eye contact, use only in well-ventilated settings, avoid dust generation, keep away from food and beverages
Safe Storage Conditions: Store in tightly sealed original packaging, in a dry, well-ventilated place, away from incompatible substances such as strong oxidizers and acids
Conditions to Avoid: Moisture, excess heat, direct sunlight, potential static discharge
Incompatible Materials: Strong acids, bases, oxidizing agents
Engineering Controls: Local exhaust ventilation, laboratory fume hoods recommended
Respiratory Protection: NIOSH-approved dust respirator for uncontrolled airborne exposure
Hand Protection: Chemical-resistant gloves made of nitrile or neoprene
Eye Protection: Safety goggles or face shield
Skin Protection: Lab coat, closed footwear, long sleeves
Hygiene Measures: Wash hands after handling, avoid eating or drinking in handling areas, remove contaminated clothing
Physical State: Solid, powder or crystalline
Appearance: White to off-white
Odor: Odorless or faint
Melting Point: 176-180°C
Boiling Point: Not available
Solubility: Freely soluble in water, slightly soluble in ethanol
pH (1% solution): 4.0 - 6.0
Vapor Pressure: Negligible
Partition Coefficient (log Kow): Not determined
Flash Point: Not applicable
Explosion Limits: No data
Autoignition Temperature: No data
Density: Not available
Chemical Stability: Stable under normal handling and storage conditions
Reactive Hazards: No significant reactive hazards under recommended use
Hazardous Polymerization: Will not occur
Incompatible Materials: Strong acids, bases, and oxidizers may react causing decomposition
Decomposition Products: Toxic fumes of sulfur oxides, carbon monoxide, carbon dioxide can form at high temperatures
Conditions to Avoid: Heating, moisture, open flames, static electricity
Likely Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: LD50 (oral, rat) around 900 mg/kg, data may vary
Chronic Effects: Potential for skin and respiratory sensitization with prolonged exposure
Carcinogenicity: No classification by IARC, NTP, or OSHA
Reproductive Toxicity: No clear evidence
Symptoms of Exposure: Drowsiness, dry mouth, blurred vision, rashes, gastrointestinal upset, breathing difficulties in sensitive individuals
Target Organs: Possibly affects central nervous system, skin, mucous membranes
Aquatic Toxicity: Data not fully available, precautionary approach advised
Persistence and Degradability: Potentially non-biodegradable, may persist in environment
Bioaccumulative Potential: Low expected due to solubility and structure
Mobility in Soil: May leach to groundwater if released in significant quantities
Other Adverse Effects: Avoid large releases to natural waters or sewage systems
Waste Disposal Methods: Dispose as hazardous chemical waste following local and national regulations, incinerate in authorized facility if permitted
Container Disposal: Rinse thoroughly, render container unusable, follow chemical container disposal rules
Environmental Precautions: Avoid dispersing dust into air or draining to water systems, do not landfill untreated
UN Number: Not classified as a regulated material for ground, air, or water transport based on available data
Transport Hazard Class: Not designated
Packing Group: None
Labeling Requirements: Standard chemical labeling, no special transport signage needed under current guidelines
Special Precautions: Shield from moisture and direct sunlight during transit, keep sealed
Transport in Bulk: Follow Good Distribution Practices for pharmaceuticals
International Inventories: Noted in many pharmaceutical compendia and chemical listings
SARA Title III (Section 313): Not listed
OSHA Hazard Communication: Classified hazardous based on acute toxicity and sensitizer properties
TSCA Status: For research and pharmaceutical use, typically not TSCA regulated
WHMIS Classification: Designated hazardous for acute toxicity and sensitizing effects in Canadian jurisdictions
EU REACH: Included on some lists for regulated pharmaceutical ingredients
Other Regulations: Use under strict professional control, maintain documentation of handling, keep MSDS available for all personnel
