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Product Name: Mebendazole
Molecular Formula: C16H13N3O3
Molecular Weight: 295.3 g/mol
CAS Number: 31431-39-7
Product Use: Anthelmintic, pharmaceutical ingredient
Synonyms: Methyl 5-benzoylbenzimidazole-2-carbamate
Manufacturer Information: Listed on each package label or supplier’s details, including address and contact
Emergency Telephone: Found through local poison control center or company hotline
Recommended Restrictions: Not intended for veterinary or unapproved human use
GHS Classification: Reproductive Toxicity Category 2, Acute Oral Toxicity Category 4, Eye Irritation Category 2
Route of Exposure: Ingestion, skin contact, eye contact, inhalation of dust
Signal Word: Warning
Hazard Statements: Harmful if swallowed; suspected of damaging fertility or the unborn child; causes serious eye irritation
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; use personal protection for eyes
Other Hazards: Avoid environmental release due to persistence and toxicity concerns
Mebendazole: 98-100%
Impurities: Not more than 2% unspecified related compounds; minor pharmaceutical excipients or synthesis residuals may be present depending on manufacturer process
Other Ingredients: None significant for hazard concerns outside of pure active bulk
Inhalation: Remove to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, get medical help if irritation persists
Eye Contact: Rinse thoroughly with water for several minutes, remove contact lenses if present and easy, continue rinsing, seek medical advice if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, give water if victim is conscious, get medical assistance immediately
Most Important Symptoms: May include nausea, headache, abdominal discomfort, irritation to respiratory passages or skin, potential reproductive effects
Suitable Extinguishing Media: Water spray, CO2, foam, dry chemical powder
Unsuitable Extinguishing Media: Do not use direct water stream on burning powder dust
Unusual Fire and Explosion Hazards: Fine dusts may form explosive mixtures with air, risk of toxic fumes under fire conditions
Special Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing
Hazardous Combustion Products: Oxides of nitrogen, carbon monoxide, carbon dioxide, other toxic organic vapors
Advice for Firefighters: Evacuate area, contain runoff, do not breathe combustion gases
Personal Precautions: Wear suitable protective gloves, goggles, dust mask or respirator
Environmental Protection: Prevent further leakage; avoid discharge into drains, surface or groundwater
Spill Cleanup Methods: Use HEPA vacuum or wet methods to pick up powder, avoid dry sweeping, place in suitable waste container for disposal, ventilate area after cleanup
Reference to Other Sections: See exposure controls and disposal guidance for additional support steps
Safe Handling Advice: Work in a well-ventilated space, minimize dust generation, wear proper PPE, avoid direct contact with skin, eyes, and clothing
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke during use
Storage Conditions: Store locked up in original tightly closed container, cool and dry area, away from light and incompatible materials such as strong oxidizers or acids
Specific End Uses: Pharmaceutical applications only as prescribed, not for non-medical laboratory projects
Occupational Exposure Limits: No established ACGIH or OSHA exposure limits, minimize exposure by good industrial hygiene and engineering controls
Engineering Controls: Local exhaust ventilation or fume hood recommended
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), safety goggles, lab coat or protective uniform, dust mask or respirator if airborne dust a risk
Environmental Controls: Avoid environmental release, follow proper waste and air handling methods
Appearance: White to off-white crystalline powder
Odor: Odorless or faintly aromatic
Odor Threshold: Data not available
pH: Not applicable (insoluble in water)
Melting Point: 288–292°C
Boiling Point: Decomposes before boiling
Flash Point: Not readily flammable, data not applicable
Evaporation Rate: Not relevant (solid substance)
Flammability: Not easily flammable in bulk, but fine dust presents explosive risk
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: Negligible
Vapor Density: Not applicable
Relative Density: 1.38–1.40 g/cm³
Solubility: Practically insoluble in water, sparingly soluble in some organic solvents
Partition Coefficient (Log Pow): Estimated 1.6
Auto-Ignition Temperature: Data not established
Decomposition Temperature: Above 290°C
Viscosity: Not applicable
Reactivity: Stable under normal handling conditions
Chemical Stability: Stable when stored in dry, cool, light-protected conditions
Possibility of Hazardous Reactions: No dangerous reactions under normal processing
Conditions to Avoid: Excess heat, light, incompatible materials such as oxidizing agents
Incompatible Materials: Strong acids, strong bases, powerful oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, other irritant or toxic organic vapors on combustion or thermal decomposition
Routes of Exposure: Mainly oral; possible dermal and ocular risk, inhalation of fine particles
Acute Toxicity: Oral LD50 (rat): 940–1700 mg/kg
Skin Corrosion/Irritation: Mild to moderate irritation on prolonged contact
Eye Damage/Irritation: Causes severe eye irritation
Respiratory Sensitization: May cause short-term respiratory discomfort if dust inhaled
Skin Sensitization: Low frequency but repeated exposure may increase risk
Germ Cell Mutagenicity: Negative in most in-vitro tests; equivocal in some animal models
Carcinogenicity: Not listed by NTP, IARC, OSHA
Reproductive Toxicity: Suspected human reproductive hazard, teratogenic effects observed in animal studies at high doses
STOT (Specific Target Organ Toxicity): Target organs include liver, testis in animal models during chronic exposure
Symptoms of Exposure: Abdominal pain, nausea, allergic skin reactions, eye redness or watering, headaches, potential developmental risk
Ecotoxicity: Toxic to aquatic organisms (Daphnia EC50: 2.6 mg/L, 48h; Fish LC50: 8.1 mg/L, 96h)
Persistence and Degradability: Moderately persistent, not readily biodegradable, potential to bioaccumulate
Bioaccumulative Potential: Protein-binding properties, moderate-to-high potential in aquatic food chains suggested by log Pow and animal studies
Mobility in Soil: Limited mobility, binds to soil particles, can reach surface runoff after heavy use
Other Adverse Effects: Considerable risk if released in quantity to water bodies or soils, pharmaceutical residues have been detected downstream from manufacturing or disposal sites
Product Disposal: Dispose of unused or waste material through authorized chemical waste incinerator with afterburner and scrubber, or contact appropriate hazardous waste handler
Container Disposal: Decontaminate with detergent before recycling or discarding in compliance with local regulations
Environmental Precautions: Do not flush into drains, sewers, or natural environments
Handling of Waste: Use personal protective equipment during waste handling to avoid secondary exposure
Regulatory Considerations: Comply with all national, regional, and local environmental and safety laws for pharmaceutical waste
UN Number: Not classified as a dangerous good for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant under current criteria, but avoid spills to avoid ecological risk
Special Precautions for Transport: Transport in tightly closed containers, shielded from light and moisture, handle as pharmaceutical with hazard awareness
EU: Subject to Regulation (EC) No 1907/2006 (REACH), listed on EINECS/ELINCS
US: Listed on TSCA for research, FDA-monitored as a pharmaceutical
Japan: Listed on ENCS
Canada: DSL/NDSL listed
Other Global Listings: Included on Australia AICS and China IECSC
Health and Safety Laws: Handle according to Occupational Health Guidelines for hazardous pharmaceuticals
Workplace Controls: Subject to medical monitoring and workplace exposure tracking if handled in bulk or manufacturing settings
Labeling Requirements: Include hazard pictograms, precautionary statements, and safety instructions inline with local GHS standards
