© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Matrine
Chemical Formula: C15H24N2O
CAS Number: 519-02-8
EINECS Number: 208-244-1
Molecular Weight: 248.36 g/mol
Synonyms: Sophora alkaloid, matrine base
Manufacturer: Industrial chemical suppliers licensed for plant extraction and processing
Recommended Use: Agricultural pesticide, insect deterrent, experimental pharmaceutical application
Restrictions: Not for food, feed, or any human ingestion; handle in controlled laboratory or industrial facilities only
Contact Information: Emergency numbers should always be provided by the supplier; reports to local poison control strongly recommended on exposure
GHS Classification: Acute toxicity (oral, dermal, inhalation): Category 4; Eye irritation: Category 2A; Skin sensitization possible
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause skin and eye irritation, respiratory discomfort under acute exposures
Precautionary Statements: Avoid breathing dusts, fumes, or vapors; wash thoroughly after handling; use personal protective equipment as specified for chemical handling
Potential Health Effects: Ingestion may cause nausea, vomiting, nervous system effects like headaches, muscle spasms; inhalation of powders may irritate airways or lungs; skin and eye contact may cause redness or mild inflammation
Environmental Hazards: Toxic to aquatic life, potential for accumulation in soils if improperly disposed of
Ingredient: Matrine
Content Range: Usually 98% or higher for technical grade
Impurities: Trace alkaloids (less than 2%) from Sophora species
Stabilizers/Additives: None commonly added in analytical or pure powder form
Physical State: Crystalline powder, white to pale yellow
Component Disclosure: Full material identity should match the listed purity on supplier certification with batch numbers traceable for recall or regulatory checking
If Inhaled: Move to fresh air, seek immediate medical attention if any difficulty breathing occurs, provide artificial respiration as necessary
If on Skin: Remove contaminated clothing, wash area thoroughly with soap and water, seek treatment for persistent rash or irritation
If in Eyes: Flush eyes with running water for at least 15 minutes, remove contact lenses if applicable, do not allow victim to rub eyes, consult medical personnel
If Swallowed: Rinse mouth, do not induce vomiting except under direct medical instruction, call poison control, provide details on amount and timing of exposure
Advice to Physician: Treatment should address symptoms; close observation necessary for delayed onset systemic effects such as central nervous system symptoms
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or foam; water spray only for cooling containers
Specific Hazards: Product may decompose releasing toxic vapors of nitrogen oxides, carbon monoxide, and other organics during fire
Special Protective Equipment: Wear full firefighting gear, self-contained breathing apparatus, chemical-resistant gloves
Thermal Decomposition: Above 240°C product breaks down to hazardous gases; avoid confined area combustion
Precautions for Firefighters: Approach fire from upwind, avoid runoff to water systems, remove containers if safety allows
Personal Protection: Isolate area, ventilate, limit access to trained personnel in PPE (respiratory protection, gloves, goggles)
Environmental Precautions: Prevent further leakage or spillage if safe, avoid contamination of drains, soil, and surface water
Cleanup Methods: Collect with non-sparking tools, transfer into closed, labeled waste containers, decontaminate area with damp cloths that get disposed as chemical waste
Reporting Procedures: Notify local environmental and health authorities if spill exceeds reportable quantity, document incident for workplace safety logs
Handling: Avoid dust generation, do not eat, drink, or smoke while working, use with adequate local and general exhaust ventilation, ensure containers are tightly sealed after use
Storage Conditions: Store at room temperature in a cool, dry, well-ventilated area out of direct sunlight, keep away from strong oxidizers and acids
Packaging Materials: Preferentially keep in original chemically-resistant containers with clear labeling by content and hazard status
Special Requirements: Maintain inventory logs, segregate from incompatible materials, review shelf-life and rotate stock accordingly
Occupational Exposure Limits: No established national occupational exposure limits; handle as if moderately toxic material pending further studies
Engineering Controls: Use local exhaust ventilation or chemical fume hood, employ closed transfer systems in industrial applications
Personal Protective Equipment: Chemical splash goggles, gloves resistant to alkaloids (nitrile or neoprene), lab coats or chemical-resistant coveralls, NIOSH-approved respirator for dust or aerosol
Hygiene Measures: Wash hands after use, avoid hand-to-mouth contact, do not touch face mid-process, keep PPE clean and maintained
Environmental Controls: Employ filter systems to capture powder emissions, use spill containment pallets and segregated drainage zones
Appearance: White to pale yellow crystalline solid
Odor: Odorless
pH: No information for solid, neutral in aqueous solution on dilution
Melting Point: 76-78°C
Boiling Point: Decomposes before boiling under atmospheric pressure
Flash Point: Not determined (expected greater than 100°C, handle as non-flammable in solid form)
Solubility: Slightly soluble in water, more soluble in ethanol and organic solvents
Vapor Pressure: Not measurable at ambient condition
Density: Around 1.2 g/cm³
Partition Coefficient: No data available
Reactivity: Stable under specified storage and handling conditions
Chemical Stability: Stable in closed containers at recommended temperatures, avoid reactive contact with oxidizers
Possibility of Hazardous Reactions: No dangerous polymerization expected, hazardous decomposition if heated strongly or mixed with oxidizers
Conditions to Avoid: Excessive heat and moisture, proximity to acid or oxidizer chemicals
Incompatible Materials: Strong acids, strong oxidizing agents like peroxides and perchlorates
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, and traces of toxic alkaloid fumes under combustion
Acute Toxicity: Oral LD50 for rats: 570 mg/kg; may cause central nervous system depression, muscle spasms, at higher doses convulsions
Skin Corrosion/Irritation: Transient mild irritation in sensitive individuals, no severe skin effects in limited animal studies
Serious Eye Damage/Irritation: Moderate irritation, possible reversible conjunctivitis
Respiratory Sensitization: Not classified; dust inhalation may still cause throat discomfort
Carcinogenicity: No classification by IARC, NTP, or OSHA; insufficient data for chronic exposure
Reproductive Toxicity: Not specifically studied or regulated, possible toxicity at high doses in animal models
Other Effects: Neurotoxicity possible on substantial accidental ingestion; data gap for long-term human health effects
Aquatic Toxicity: Harmful to aquatic organisms; LC50 in fish (Zebra danio) under 96 hrs: 35 mg/L
Persistence and Degradability: Moderately biodegradable in aerobic conditions; potential for persistence or build-up in cold or poorly drained soil
Bioaccumulation: Limited bioaccumulative potential due to low solubility and rapid decomposition in natural waters
Mobility in Soil: Low volatility, likely binds to organic matter in soil, avoid application near surface water
Other Hazardous Effects: Disruption to beneficial soil insects and aquatic invertebrates, toxic to pollinators if misapplied
Waste Treatment Methods: Dispose of in accordance with state/national regulations for agricultural chemicals or pesticide waste
Product Disposal: Incinerate in licensed, controlled chemical waste incinerators; do not landfill large volumes or flush powder to drains
Contaminated Packaging: Triple rinse before disposal, puncture to prevent reuse, label as hazardous waste
Precautions: Never dispose near water bodies; document and track product lifecycle through regulated chains
UN Number: Not classified for most surface transport but check local hazardous substance listings
Proper Shipping Name: Matrine, technical
Hazard Class: Not regulated as dangerous goods in standard quantities under GHS; bulk shipments may require packaging group III for moderate toxicity
Packing Group: III (where classified)
Special Transport Precautions: Keep away from food/feedstuffs, provide documentation for chain-of-custody and emergency response info
Labels Required: “Harmful” symbol or local equivalent for agricultural materials
Global Inventory Listings: Registered under multiple regional chemical inventories (e.g. IECSC, TSCA)
Regulatory Status: Approved for use in agricultural and veterinary practices in several countries with concentration restrictions
Worker Protection Standard: Personal protective measures regulated in jurisdictions applying pesticide safety codes
SARA Title III: Not a listed “Extremely Hazardous Substance” or “Toxic Release Inventory” chemical
Other Requirements: Local, national, and international regulations may restrict storage, workplace exposure, environmental application and disposal
Reporting Obligations: Mandatory incident and spill reporting under environmental and occupational health legislation
