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Product Name: Maropitant Citrate
Chemical Name: 2-Piperidinone, 4-(3-methoxy-2-methylphenyl)-1-(1-methyl-4-(3-methyl-2-pyridinyl)-1H-imidazol-5-yl)carbonyl-, citrate (1:1)
Common Trade Names: Cerenia
Synonyms: Maropitant, Cerenia Injectable
CAS Number: 158861-67-7
Manufacturer: Veterinary pharmaceutical companies, details available on vial or packaging
Recommended Use: Antiemetic for veterinary purposes
Contact Information: Emergency phone numbers, address, and technical support listed per manufacturer
Classification: Not classified as hazardous under GHS for general handling
Hazard Statements: May cause mild skin or eye irritation, respiratory tract irritation possible with high dust
Signal Word: Not applicable
Pictograms: None required under usual conditions
Precautionary Statements: Avoid generating dust or aerosol, wash hands after handling, avoid inhalation
Route of Exposure: Inhalation, skin and eye contact, ingestion
Target Organs: Central nervous system in animal studies
Other Hazards: May cause allergic reactions in sensitive individuals
Component: Maropitant citrate (active ingredient)
Chemical Formula: C32H40N2O8
Concentration: Varies by formulation. Typical injectable or tablet 10-50 mg/ml or mg/tab
Excipients: May include gelatin, lactose, microcrystalline cellulose, sodium metabisulfite, and water for injection or mannitol
Impurities: Negligible or below reporting limits under GMP
Inhalation: Remove to fresh air, provide oxygen if needed, contact physician if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, seek medical advice if irritation continues
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention for persistent symptoms
Notes for Healthcare Providers: Treat symptomatically and supportive care, limited human data available
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray
Unsuitable Media: Direct water jets for powder fires
Specific Hazards: Emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide under fire conditions
Protective Equipment: Self-contained breathing apparatus, full protective clothing
Firefighting Instructions: Move containers from fire area if possible, cool containers with water spray
Personal Precautions: Wear appropriate PPE such as gloves, lab coat, dust mask, goggles
Environmental Precautions: Prevent further leakage or spillage if safe, avoid entering waterways
Spill Cleanup Methods: Sweep up material and place in appropriate containers for waste disposal, ventilate area, rinse area with detergent and water
Special Procedures: Notify authorities if product enters environment in significant quantities, dispose according to local and national regulations
Handling: Minimize dust or mist generation, avoid ingestion, wash hands before eating or drinking, use in well-ventilated spaces
Storage: Store in tightly closed container away from incompatible materials, below 25°C, protect from light and moisture
Other Recommendations: Keep out of reach of children and unauthorized persons, maintain proper inventory records
Control Parameters: No established occupational exposure limits for Maropitant Citrate
Engineering Controls: Work in fume hood or area with local exhaust ventilation if possible
Personal Protection: Chemical-resistant gloves, protective eyewear, long-sleeved clothing, laboratory coat
Respiratory Protection: Respirator mask with particulate filter when risk of airborne exposure exists
Hygiene Measures: Wash hands thoroughly after handling, avoid eating or drinking in work area, remove contaminated clothing promptly
Appearance: White or off-white crystalline powder (pure), clear or colorless solution (injectable form)
Odor: Odorless
Odor Threshold: Not determined
pH (1% Solution): 3.0 - 4.0 (injectable)
Melting Point: 155–165°C (pure)
Boiling Point: Decomposes before boiling
Solubility: Soluble in water (injectable formulation), slightly soluble in common organic solvents
Vapor Pressure: Not applicable
Partition Coefficient (log Kow): Not available
Viscosity: Not applicable
Flash Point: Not flammable under normal conditions
Chemical Stability: Stable under regular conditions recommended for pharmaceuticals
Conditions to Avoid: Excessive heat, moisture, direct sunlight, strong oxidizers
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide may form
Polymerization: Not likely to occur
Acute Toxicity: Low in animals, clinical signs include mild CNS effects at high doses
Skin Corrosion/Irritation: Can cause slight irritation to skin
Eye Damage/Irritation: May lead to mild, reversible irritation
Carcinogenicity: No evidence from animal models
Mutagenicity: No evidence from standard tests
Reproductive Toxicity: Can affect developing fetus in animal studies at high doses
Specific Target Organ Toxicity: CNS effects in high dose animal studies
Sensitization: May cause allergic skin reactions in hypersensitive individuals
Ecotoxicity: Data limited, no large scale impact reported, possible risk to aquatic organisms if released in bulk
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulative Potential: Potential low, based on molecular profile
Mobility in Soil: Data not available, possible low mobility
Other Harmful Effects: Avoid large-scale release to sewage or waterways to prevent accidental exposure to non-target species
Waste Treatment Methods: Collect waste in approved containers, incinerate in licensed facility or use hazardous waste disposal service
Contaminated Packaging: Rinse thoroughly before disposal, observe national and local regulations
Disposal Precautions: Do not dispose of via household garbage or regular drain, avoid environmental release
UN Number: Not regulated as dangerous good for transport
UN Proper Shipping Name: Not applicable
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions: Transport in secure containers, avoid contamination with food or feed
Environmental Hazards: Not classified as marine pollutant
TSCA: Not specifically listed
REACH Status: Not registered for human use
SARA Title III: Not listed as reportable substance
OSHA Hazard Communication: Not considered hazardous in normal use
Other Regulations: Subject to regulation by national health and veterinary authorities for veterinary pharmaceutical use
Labeling Requirements: Follow local health and safety laws for labeling veterinary products containing Maropitant Citrate
