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Material Safety Data Sheet – Marbofloxacin

Identification

Product Name: Marbofloxacin
Chemical Formula: C17H19FN4O4
Common Synonyms: Marbocyl, Zeniquin, Forcyl
CAS Number: 115550-35-1
Manufacturer: Refer to supplier documentation
Recommended Use: Antimicrobial agent for veterinary application
Restrictions on Use: Not for human consumption or direct contact

Hazard Identification

Classification: Harmful if swallowed or inhaled, suspected of damaging fertility or unborn child, causes mild skin and eye irritation, may cause allergic skin reactions
Label Elements: Health Hazard, Exclamation Mark
Signal Word: Warning
Hazard Statements: May cause respiratory irritation, reproductive toxicity, moderate environmental hazard
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use increases risks for sensitive individuals, especially pregnant persons or those with pre-existing respiratory illness

Composition / Information on Ingredients

Substance: Marbofloxacin
Concentration: ≥98% (by weight)
Impurities: Trace residual solvents, water moisture
Other Ingredients: None intentionally added

First Aid Measures

Inhalation: Move to fresh air right away, seek medical attention if symptoms like shortness of breath, coughing, or chest tightness occur
Skin Contact: Remove contaminated clothing, wash skin with soap under running water for several minutes, monitor for signs of skin irritation
Eye Contact: Rinse gently with water for up to 15 minutes, consult medical personnel if discomfort persists
Ingestion: Rinse mouth, do not induce vomiting unless directed by medical professionals, seek immediate medical guidance, especially if large quantities swallowed
Most Important Symptoms: Nausea, respiratory distress, rash, eye irritation, dizziness in high doses

Fire-Fighting Measures

Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam; avoid direct water jet
Special Hazards: Will emit toxic fumes of nitrogen oxides, hydrogen fluoride in a fire; can aggravate respiratory symptoms
Protective Equipment: Wear self-contained breathing apparatus and suitable protective clothing to prevent exposure
Firefighting Instructions: Move containers from fire area if safe, prevent run-off from entering drains or water systems

Accidental Release Measures

Personal Precautions: Restrict access to area, ventilate if possible
Protective Equipment: Gloves, safety goggles, NIOSH-certified dust mask or respirator
Spill Response: Avoid creating dust, sweep up spills using non-sparking tools, collect in suitable waste container for disposal
Environmental Precautions: Avoid discharge into sewers, drains, or natural water bodies
Methods for Clean-Up: Dampen powder to minimize dust; dispose of waste with approved hazardous materials company

Handling and Storage

Handling Precautions: Work in well-ventilated area, wear protective gloves and eyewear, avoid creating dust, prevent contact with skin and eyes
Safe Storage: Keep container tightly closed, store in a dry, cool and well-ventilated place, protect from light and moisture, segregate from incompatible materials such as strong oxidizers and acids
Other Recommendations: Do not eat, drink or smoke while working; clean work surfaces after handling

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation, fume hood suggested for bulk handling
Personal Protection – Respiratory: Use approved respirator if exposure limits may be exceeded
Eye Protection: Safety goggles with side shields
Skin Protection: Chemical-resistant gloves, lab coat or apron
Work Hygiene: Wash thoroughly after handling, launder clothing before reuse
Exposure Limits: No occupational exposure limit value established, but minimize dust to prevent inhalation issues

Physical and Chemical Properties

Appearance: Off-white to pale-yellow crystalline powder
Odor: Not distinctive, practically odorless
pH: 4.0 to 6.0 (1% solution in water)
Melting Point/Freezing Point: 196-200°C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in dilute acids and bases, slightly soluble in water
Specific Gravity: Not determined
Vapor Pressure: Not applicable
Particle Size: Fine powder, risk of airborne particulates
Flash Point: Data not available, consider combustible at high temperature
Bulk Density: Typical for crystalline antimicrobials, varies by batch

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Minimal reactivity when handled and stored properly
Possible Hazardous Reactions: Exposure to strong acids, bases, or oxidizers may lead to decomposition
Conditions to Avoid: High humidity, temperature extremes, direct sunlight
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, hydrogen fluoride
Incompatible Materials: Strong oxidizing minerals, strong acids and bases, iron salts

Toxicological Information

Acute Toxicity: LD50 (oral, rat): approximately 5000 mg/kg, mild to moderate toxicity
Chronic Effects: Potential risk of reproductive toxicity, slight evidence for liver and kidney impact in prolonged high-dose studies
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Symptoms: Headache, drowsiness, dermatological irritation, mild gastrointestinal upset
Carcinogenicity: Not classified as carcinogen by IARC, OSHA, NTP
Additional Risks: Allergic skin reactions possible with frequent contact

Ecological Information

Ecotoxicity: Toxic to aquatic life with long lasting effects, risk for disruption of microbial ecosystems
Persistence and Degradability: Persistent in soil and water, does not biodegrade easily
Bioaccumulation Potential: Low to moderate risk, concentrates in sediment
Mobility in Soil: Moderate, may leach into groundwater in significant quantities
Other Adverse Effects: Potential to spread antimicrobial resistance in aquatic environments

Disposal Considerations

Waste Disposal: Dispose of as hazardous pharmaceutical waste, do not release into environment or sewage systems
Recommended Methods: Incineration at approved facility, chemical neutralization may be considered for large quantities under expert guidance
Packaging Disposal: Contaminated containers and materials should also follow hazardous waste protocol

Transport Information

UN Number: Not regulated as a hazardous material for ground or air shipment in small laboratory quantities
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not assigned
Packing Group: None
Special Precautions: Prevent packages from being crushed or punctured during transit, use leak-proof containers
Environmental Hazards: Not a marine pollutant in packaged quantities, take measures to avoid accidental spillage

Regulatory Information

Inventory Status: Listed or exempted under most chemical inventories (TSCA, EINECS/ELINCS, AICS)
OSHA Status: Not listed as hazardous chemical under OSHA hazard communications
SARA Title III: Not regulated under Sections 302/304/313
California Proposition 65: Not on Proposition 65 list
Other Regulatory Notes: Use and handling restricted to trained professionals for approved veterinary uses in accordance with local and national regulations