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Product Name: Maduramicin Ammonium
Chemical Family: Polyether ionophore antibiotic; coccidiostat
CAS Number: 155862-77-4
Synonyms: Maduramycin ammonium salt, CP-60,395
Recommended Use: Anticoccidial agent in animal feed (poultry)
Manufacturer: Contact information for the producing or distributing company, address, phone number for further assistance
Emergency Contact: 24-hr poison control center phone number or manufacturer emergency line
Hazard Classification: Acute toxicity (oral, inhalation, dermal), hazardous to aquatic life, specific organ toxicity (repeated exposure)
Signal Word: Danger
Hazard Statements: Harmful if swallowed, inhaled, or absorbed through skin; causes damage to organs through prolonged or repeated exposure (heart, muscle tissue); toxic to aquatic organisms with long-lasting effects
Pictograms: Skull and crossbones, exclamation mark, environment
Precautionary Statements: Avoid breathing dust or fumes; prevent release into environment; wear protective gloves, clothing, and eye protection; wash hands thoroughly after handling; do not eat, drink, or smoke during use
Chemical Substance: Maduramicin ammonium
Concentration: Pure active ingredient typically 98% or higher (technical grade), with remaining content as inert formulation aids
Impurities: Minor byproducts from fermentation or synthesis, generally less than 2% total
Component Breakdown: No hazardous ingredients other than active compound identified above; formulation additives usually proprietary but nonhazardous
Inhalation: Move affected person to fresh air; keep at rest in comfortable position; seek medical advice if symptoms develop (shortness of breath, dizziness)
Skin Contact: Remove contaminated clothing immediately; wash affected skin with soap and water for at least 15 minutes; seek medical attention for irritation or persistent symptoms
Eye Contact: Immediately flush eyes gently with large amounts of water for no less than 15 minutes, lifting eyelids occasionally; seek immediate medical attention
Ingestion: Rinse mouth; do NOT induce vomiting unless directed by medical personnel; seek immediate medical help; provide information about the substance to responders
Symptoms: Nausea, vomiting, muscle tremors, difficulty breathing, irregular heartbeat, convulsions with overexposure
Suitable Extinguishing Media: Dry chemical, CO2, water spray (fog), foam
Unsuitable Media: Direct water jet may cause contamination spread
Special Hazards: Product may give off toxic fumes (carbon monoxide, nitrogen oxides, unidentified organics) during combustion
Protective Equipment: Wear self-contained breathing apparatus and full firefighting gear; avoid breathing vapors and dust
Advice for Firefighters: Stay upwind and keep out of low areas; prevent contaminated water runoff entering drains or watercourses
Personal Precautions: Wear suitable protective gear (gloves, goggles, respirator); restrict access to spill area; avoid dust formation
Environmental Precautions: Prevent material entering sewer, surface water, or soil; control spread with barriers if possible to reduce environmental impact
Cleanup Methods: Scoop or sweep up spilled powder carefully; place in suitable labeled closed container for safe disposal; avoid raising dust; ventilate area well
Decontamination: Wash spill site after material pickup is complete; collect washings and residues for disposal
Precautions for Safe Handling: Work in well-ventilated area; minimize dust generation; use local exhaust or fume hood; wear recommended personal protective equipment
Hygiene: Wash hands and face after handling; do not eat, drink, or smoke where product is used
Storage Conditions: Keep container tightly closed in a dry, cool, well-ventilated area; protect from moisture, heat, incompatible substances
Incompatibilities: Strong acids, oxidizing agents; avoid prolonged exposure to air and light
Shelf Life: Stable under recommended storage conditions; check product-specific expiration date
Exposure Limits: No established occupational exposure limits; handle as hazardous dust
Engineering Controls: Use local ventilation and/or general exhaust to control airborne concentrations below nuisance levels
Respiratory Protection: Use NIOSH-approved dust/mist respirator if airborne exposure likely or ventilation inadequate
Eye Protection: Safety goggles or face shield required for handling powder or solution
Skin Protection: Wear chemical-resistant gloves (nitrile, neoprene), lab coat, long sleeves to reduce skin exposure
Other Protective Equipment: Eye wash station and emergency shower accessible in work area; remove contaminated clothing and wash before reuse
Appearance: White to pale yellow crystalline powder
Odor: Mild, characteristic fermentation odor
Odor Threshold: Not determined
pH (1% solution): 4.5–7.0
Melting Point: 175–185°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not data available (not flammable)
Evaporation Rate: Not applicable
Vapor Pressure: Negligible at ambient temperature
Solubility: Freely soluble in ethyl acetate and methanol, very slightly soluble in water
Partition Coefficient (log Kow): Estimated moderate to high (lipophilic)
Vapor Density: Not relevant
Density: Approx. 1.2–1.3 g/cm³
Viscosity: Solid material; not applicable
Chemical Stability: Stable when stored under recommended conditions; sensitive to light; degrades in acidic or alkaline environments
Reactivity: No rapid polymerization or violent reaction hazards identified
Conditions to Avoid: Moisture, extreme temperatures, exposure to light and air
Incompatible Materials: Strong oxidizers, acids, bases; avoid co-storage with incompatible chemicals
Hazardous Decomposition: Burning may produce carbon monoxide, carbon dioxide, ammonia, nitrogen oxides, other unknown gases
Acute Toxicity: LD50 (oral, rat): approximately 4.3 mg/kg; low oral LD50 means high acute toxicity
Routes of Exposure: Inhalation, skin contact, ingestion, possible eye absorption
Symptoms: Muscle tremors, loss of coordination, diarrhea, vomiting, cardiac arrhythmias, possibly convulsions and death in severe overdose
Chronic Effects: Cardiac and skeletal muscle degeneration from repeated low-level exposure
Carcinogenicity: No evidence in animal studies that maduramicin ammonium is carcinogenic
Mutagenicity and Reproductive Toxicity: Studies do not indicate mutagenic or teratogenic effects at expected exposure levels
Target Organs: Heart, skeletal muscle, nervous system
Aspiration Hazard: Not anticipated under normal usage conditions
Ecotoxicity: Highly toxic to aquatic organisms (fish, daphnia); may cause long-lasting effects in water
Persistence and Degradability: Moderately persistent in the environment; degradation products may still pose risk
Bioaccumulation: Potential for moderate accumulation in aquatic species due to lipophilicity
Mobility in Soil: Expected to adsorb to soils, especially organic-rich soils; may leach with runoff
Other Adverse Effects: Avoid release to the environment; major risks to aquatic ecosystems where improperly managed
Product Disposal: Dispose of unused or contaminated product at licensed hazardous waste facility; never flush to drains or natural waterways
Container Disposal: Triple rinse and then puncture empty containers before disposal; follow regulations for hazardous materials
Precautions: Label waste properly; prevent accidental release during handling and transport
UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains maduramicin ammonium)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II (medium danger)
Sea (IMDG): Marine pollutant, classified as environmentally hazardous
Air (IATA): Regulated for air freight; follow cargo shipper’s instructions
Special Transport Precautions: Keep in sturdy, sealed containers; secure from physical damage and extreme conditions; communicate hazard to handlers
Global Inventories Status: Check for listing under TSCA (US), EINECS/ELINCS (Europe), DSL (Canada), AICS (Australia), other national inventories
OSHA Classification: Hazardous chemical under Hazard Communication Standard
EPA Status: Regulated for environmental discharge and pharmaceutical use; not registered for direct application in food production animals in every jurisdiction
Signal Phrases: DANGER/Peligro
SARA 313 Reporting: Not specifically listed, but all chemical releases must be reported if causing environmental harm
Other National or Regional Controls: Local guidelines for veterinary pharmaceutical disposal, agricultural use, and food chain contamination apply
