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Product Name: Madecassoside 90% (White)
Chemical Formula: C48H78O20
Synonyms: Madecassic acid glycoside
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Recommended Uses: Cosmetic ingredient, skin care additive
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CAS Number: 34540-22-2
EC Number: 252-379-3
GHS Classification: Not classified as hazardous under GHS
Hazard Statements: Possible irritation to eyes and skin from dust
Pictograms: None required at 90% purity
Signal Word: None
Precautionary Statements: Minimize dust, avoid breathing airborne particles, wash hands after use
Other Hazards: Large amounts of powder can become airborne and disturb breathing in poorly ventilated areas
Component: Madecassoside
Concentration: ≥90%
Impurities/Other Ingredients: Water (as moisture), Minor triterpenoid saponins (≤10%)
CAS Number: 34540-22-2
EC Number: 252-379-3
Inhalation: Move person to fresh air, provide water, seek medical help if symptoms persist
Skin Contact: Rinse with soap and water, remove contaminated clothing
Eye Contact: Rinse gently with plenty of water for several minutes, remove contact lenses, seek medical attention if irritation continues
Ingestion: Rinse mouth, drink water, monitor symptoms, seek care if feeling unwell
Suitable Extinguishing Media: Use water spray, dry chemical powder, carbon dioxide, or foam
Unsuitable Extinguishing Media: Direct water jets may disperse dust
Special Hazards: Fine powder can create dust clouds, increasing combustion risk
Protective Equipment: Wear self-contained breathing apparatus, protective clothing, and gloves to avoid inhalation of decomposition products
Specific Hazards: Product will emit irritating or toxic decomposition fumes such as carbon monoxide and carbon dioxide in fire conditions
Personal Precautions: Ventilate area, use appropriate PPE (gloves, dust mask, goggles), avoid skin and eye contact
Environmental Precautions: Prevent spillage into drains, surface waters, or soil
Methods for Clean Up: Shovel up without making dust, sweep gently, place in a sealed bag/container for disposal according to local regulations
Other Advice: Wash affected surfaces with plenty of water after material removal
Handling: Minimize dust generation, avoid breathing dust, wear eye and skin protection, keep away from food and drink
Storage: Keep in tightly closed containers, store in a cool, dry, well-ventilated area, keep away from sunlight and moisture
Incompatibilities: Strong oxidizing agents
Special Conditions: Segregate from substances with low ignition temperatures; avoid storing above 25°C
Occupational Exposure Limits: No official exposure limits established for Madecassoside
Engineering Controls: Local exhaust recommended for handling powder, use closed systems where possible
Personal Protection: Wear dust masks (P2), safety goggles, nitrile or latex gloves, and lab coats
Hygiene Measures: Wash hands and face thoroughly after handling, avoid eating and drinking in work areas
Environmental Exposure Controls: Do not allow product to enter environment uncontrolled
Appearance: White powder
Odor: Odorless or faint characteristic scent
pH: 5.0 – 7.0 (1% solution)
Melting Point: Approximate 250°C (decomposes)
Boiling Point: Not applicable (solid degrades)
Solubility: Soluble in water and ethanol, limited in nonpolar solvents
Vapor Pressure: Negligible
Density: Approximately 1.4 g/cm³
Partition Coefficient: Not available
Viscosity: Not applicable
Flash Point: Not determined; unlikely to present flash hazard
Evaporation Rate: Not applicable (non-volatile solid)
Chemical Stability: Stable at normal temperatures and recommended storage conditions
Possibility of Hazardous Reactions: No hazardous polymerization expected
Conditions to Avoid: Excessive heat, moisture, sources of ignition, strong oxidizers
Incompatible Materials: Strong oxidizing agents, acids, bases
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, and other unknown organics
Acute Toxicity: No significant acute toxicity reported, oral LD50 (rat) > 5000 mg/kg
Skin Irritation: May cause mild irritation after prolonged or repeated exposure
Eye Irritation: Dust can cause redness or watering
Respiratory Sensitization: Dust may provoke cough or discomfort if inhaled
Chronic Effects: No data showing organ toxicity, carcinogenicity, mutagenicity, or reproductive toxicity
Other Health Effects: Topical use on skin is regarded as low risk based on cosmetic evidence
Ecotoxicity: No observed acute toxicity in aquatic life at low concentrations, not persistent
Persistence/Degradability: Readily biodegradable based on natural triterpenoid structure
Bioaccumulation Potential: Low
Mobility in Soil: Slightly mobile in moist environments, unlikely to reach groundwater
Other Adverse Effects: None anticipated, madecassoside breaks down to non-toxic products in the environment
Waste Disposal Methods: Collect in a sealed, labelled container; send to licensed waste incinerator or landfill
Hazardous Waste: Product does not qualify as hazardous under most jurisdictions
Contaminated Packaging: Rinse containers, recycle or dispose according to local regulations
Special Precautions: Prevent dust release during disposal, wear suitable PPE throughout process
UN Number: Not regulated
Proper Shipping Name: Not classified as a dangerous good
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not marine pollutant
Special Transport Precautions: Ensure package is secure and dry during transport, prevent container breakage or spillage
Labelling Requirements: Not regulated under major chemical regulations (OSHA, GHS, REACH)
Chemical Inventory Status: Listed or exempted in key jurisdictions; cross-check with national inventories as needed
Other Regulations: No special restrictions for use in cosmetics or personal care under most global regulations, subject to purity verification for specific applications
SARA Title III Sections 302/304/313: Not listed
TSCA: Exempt as a naturally occurring substance
EU Reach: Meets requirements for cosmetic ingredients, not subject to registration at provided purity
Workplace Labeling: Use appropriate signal and precautionary phrases if re-packaging
