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Product Name: Lornoxicam
Synonyms: 6-chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide
CAS Number: 70374-39-9
Recommended Use: Pharmaceutical ingredient, non-steroidal anti-inflammatory drug (NSAID)
Manufacturer: Identified by supplier information and listed locally
Contact Information: Emergency phone numbers and address provided by the supplier
Classification: Harmful if swallowed; May cause skin and eye irritation; Possible respiratory sensitizer; May cause serious damage to health by prolonged exposure
Label Elements: Hazard pictograms showing health hazard, exclamation mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes irritation, may cause allergy or asthma symptoms
Precautionary Statements: Avoid breathing dust or powder, wear protective gloves and eye protection, wash thoroughly after handling, do not eat, drink, or smoke during use
Other Hazards: Dust formation possible, presents environmental risk with aquatic toxicity concerns
Chemical Name: Lornoxicam
Common Name: Lornoxicam
CAS Number: 70374-39-9
Concentration: 100% (Active Pharmaceutical Ingredient; may vary in formulated products)
Impurities: Synthesis byproducts or residual solvents, trace levels, fully evaluated according to production method
Additives: None in pure drug substance, excipients present in formulated medications
Inhalation: Remove to fresh air immediately; seek medical advice for discomfort, irritation, or breathing problems
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing; medical attention for persistent irritation
Eye Contact: Rinse cautiously with water; remove contact lenses if present and easy; continue rinsing; consult medical aid if discomfort continues
Ingestion: Do not induce vomiting; rinse mouth thoroughly; seek immediate medical attention and provide product information
Advice to Physicians: Treat symptomatically, monitor for allergic or toxic reactions; supportive therapy as needed
Suitable Extinguishing Media: Dry chemical, water spray, carbon dioxide, appropriate foam
Specific Hazards: Combustion may produce toxic fumes such as nitrogen oxides, sulfur oxides, carbon monoxide, and hydrogen chloride
Protective Equipment: Respiratory protection, chemical resistant clothing, self-contained breathing apparatus
Precautions: Avoid inhalation of smoke or fumes, remove containers from fire area if safe, prevent water runoff from fire control from entering environment
Personal Precautions: Use respiratory protection, avoid dust generation, wear suitable gloves and eye protection
Environmental Precautions: Prevent spilled material from getting into drains, soil, groundwater, or surface waters
Containment and Cleanup: Sweep and collect spilt powder using methods that avoid dust, place in labeled waste container for disposal, ventilate affected area, wash spill site after cleanup
Disposal: Dispose of contaminated material according to local, regional, and national regulations with environmental concerns in mind
Handling: Use local exhaust ventilation to minimize exposure, avoid inhalation and contact with skin or eyes, practice good hygiene
Storage Conditions: Store in tight, light-resistant, labeled containers in a dry, cool, well-ventilated area away from incompatible substances such as acids or oxidizers
Specific Precautions: Protect from moisture, heat, and sunlight, keep containers tightly closed
Incompatibilities: Oxidizing agents, strong acids, reducing environments
Exposure Limits: No established occupational exposure limits for Lornoxicam, but handle with pharmaceutical precautions
Engineering Controls: Use fume hood, local ventilation, avoid dust and airborne particulate formation
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, laboratory coat, dedicated respiratory protection for powder handling
Hygiene Measures: Avoid eating, drinking, or smoking in work area, wash hands after handling, remove contaminated clothing
Form: Solid, crystalline powder
Color: Yellow to yellow-orange
Odor: Odorless or slightly characteristic
Molecular Weight: Approximately 371.8 g/mol
Melting Point: Around 220-226°C
Solubility: Slightly soluble in water, freely soluble in methanol and ethanol; insoluble in nonpolar solvents
pH (aqueous solution): Neutral to slightly acidic
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible
Partition Coefficient (log Kow): Approximately 1.7-2.3
Flammability: Not classified as flammable but combustible in presence of ignition source
Chemical Stability: Stable under recommended storage and handling conditions in closed containers at room temperature
Reactivity: No hazardous reactions identified under normal use; may react with strong oxidizers or acids
Hazardous Decomposition Products: Emits toxic fumes such as nitrogen oxides, sulfur oxides, and carbon monoxide if combusted
Polymerization: Will not undergo hazardous polymerization
Conditions to Avoid: Exposure to moisture, heat, strong acids, oxidizers, or direct sunlight
Acute Toxicity: Oral LD50 (rat) estimated around 500 mg/kg; risk of overdose effects if ingested in high quantities
Skin and Eye Contact: Mild to moderate irritation observed in animal tests; low risk of skin absorption
Inhalation: Can cause irritation to respiratory tract, coughing, or labored breathing with high airborne dust levels
Chronic Exposure: Possible effects include gastrointestinal disturbances, renal effects, hepatic toxicity, and allergic reactions
Sensitization: May provoke allergic responses in sensitized individuals
Mutagenicity/Carcinogenicity: No evidence of carcinogenic or mutagenic effects from standard assays, but long-term risk not fully evaluated
Reproductive Toxicity: No known reproductive risks at therapeutic doses; not recommended during pregnancy unless justified
Ecotoxicity: May be toxic to aquatic life with long-term effects, especially in low dilution or after chronic accumulation
Persistence and Degradability: Not rapidly biodegradable, potential for bioaccumulation in aquatic systems
Mobility in Soil: Moderately mobile in soil, possibility for leaching to groundwater under certain environmental conditions
Results of PBT and vPvB Assessment: Lornoxicam not classified as persistent, bioaccumulative, and toxic (PBT) or very persistent and very bioaccumulative (vPvB)
Other Adverse Effects: Avoid release to the environment, as pharmaceutical residues can affect microorganisms and aquatic species
Waste Disposal Methods: Dispose of in accordance with local, regional, national, and international regulations; incineration recommended where possible for pharmaceutical waste
Packaging Disposal: Triple-rinse containers and puncture before landfill or incineration; follow regulatory guidance
Contaminated Materials: Treat similarly to main product for all contaminated objects or clothing
Environmental Precautions: Prevent entry to waterways, drains, or soil
UN Number: Not assigned for pure Lornoxicam
Transport Hazard Class: Not classified as hazardous for road, air, or sea transport under existing conventions
Packaging Group: Not classified
Special Precautions: Protect from moisture, keep in original tightly closed containers during transport
Environmental Hazards: Not considered environmentally hazardous for transport purposes
Additional Transport Requirements: Ensure labeling and documentation match regional regulations, prevent accidental spillage or exposure during movement
Safety, Health, and Environmental Regulations: Not listed on major hazard inventories, but subject to regulation for pharmaceutical control and environmental protection
OSHA Status: Not specifically regulated under US OSHA hazard communication standard as of published date
TSCA Status: Not listed on US Toxic Substances Control Act inventory as a drug substance
EU Regulations: Listed in European Drug and Chemicals inventories, follows REACH guidelines for chemical safety
Labeling: Label in accordance with local and international requirements for pharmaceutical raw materials
Other Information: Industry best practice recommends regular review of safety literature and updated safety guidelines for laboratory and production use
