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Product Name: Lomefloxacin Hydrochloride
Chemical Formula: C17H19F2N3O3•HCl
CAS Number: 98079-52-8
Manufacturer: Pharmaceutical and research chemical suppliers distributed through licensed wholesalers
Intended Use: Antibacterial agent in human medicines, subject to prescription control
Synonyms: Lomefloxacin HCL, Lomecin, Lomex
Contact Number for Emergency: Local Poison Control, Emergency Response Services
Recommended Restrictions: Only trained personnel should handle; veterinary and human medical application under regulation
Classification: Harmful if swallowed, can irritate eyes and skin, potential eye and respiratory sensitizer
Signal Word: Warning
Pictograms: Exclamation mark for irritant
Hazard Statements: May cause allergic skin reaction; may cause respiratory tract irritation and damage if inhaled or ingested in large quantities
Precautionary Statements: Wear protective gloves, eye protection, avoid breathing dust or vapors, wash hands thoroughly after handling
Routes of Exposure: Ingestion, inhalation, skin contact, eye contact
Target Organs: Liver, kidneys, gastrointestinal tract
Medical Conditions Aggravated: Existing allergies, respiratory conditions, pre-existing skin disorders
Active Ingredient: Lomefloxacin Hydrochloride
Chemical Composition: 98–102% pure, balance includes manufacturing-related impurities at trace levels
Impurities: Less than 0.5% each, as per pharmacopeial standards
Excipient Content: Non-applicable in raw bulk material
Eye Contact: Rinse eyes with plenty of water for 15 minutes and obtain medical attention immediately
Skin Contact: Remove contaminated clothing, wash affected skin with soap and water for at least 15 minutes
Inhalation: Move to fresh air, keep victim warm and at rest, seek medical attention if symptoms appear
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical attention
Additional Advice: Show physician this MSDS document if possible
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, water spray, foam
Unsuitable Extinguishing Media: Strong water jets may spread contamination
Hazardous Combustion Products: Hydrogen chloride gas, carbon oxides, nitrogen oxides, toxic fumes
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Special Procedures: Isolate fire area, avoid contamination runoff, evacuate non-essential personnel
Personal Precautions: Use chemical-resistant gloves, goggles, respirator, lab coat
Environmental Precautions: Prevent product from entering drains or waterways, report spillage to relevant local authority
Cleanup Methods: Sweep or vacuum up material, avoid dust formation, transfer to well-labeled disposal container, wash spill site with soap and water
Disposal of Contaminated Material: Dispose of in compliance with local, state, and federal regulations, avoid flushing to sewer
Emergency Procedures: Evacuate area if necessary, ensure ventilation
Handling Guidelines: Wear appropriate personal protective equipment, avoid inhalation of dust, use in ventilated area, keep away from incompatible substances
Storage: Store in a cool, dry, well-ventilated place, tightly sealed original packaging, protect from light and moisture
Incompatibility: Oxidizing agents, acids, alkalis, strong reducing agents
Hygiene Practices: Avoid eating, drinking, or smoking during handling, always wash hands after use
Temperature Recommendations: Store below 25°C unless otherwise stated by the supplier
Engineering Controls: Use local exhaust ventilation and process enclosures if dust or vapor likely
Personal Protection: Chemical safety goggles, gloves (nitrile, neoprene), lab coat, appropriate dust mask or respirator
Hygiene Controls: Wash hands before breaks and at end of work, remove contaminated clothing immediately
Occupational Exposure Limits: No established limit for active ingredient, handle as pharmaceutical agent
Environmental Controls: Ensure product does not reach drains, sewer, or natural water sources
Appearance: White to pale yellow crystalline powder
Odor: Odorless or slight medicinal odor
Melting Point: 255–265°C (decomposition)
Solubility: Freely soluble in water, sparingly in methanol, practically insoluble in chloroform and ether
pH in Solution: Typically slightly acidic
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Bulk Density: 0.45–0.65 g/cm³
Stability in Storage: Stable under recommended storage conditions
Chemical Stability: Stable at ambient temperatures and under normal storage conditions
Conditions to Avoid: Heat, moisture, light, strong oxidizers
Reactivity: May react with oxidizing or reducing agents
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, fluorinated compounds upon combustion or decomposition
Polymerization: Will not occur under normal handling
Incompatible Materials: Strong acids, bases, oxidizing or reducing agents
Routes of Exposure: Oral, dermal, inhalation
Acute Toxicity (Oral): LD50 (rat): 2,000–4,000 mg/kg
Acute Effects: May cause nausea, vomiting, headache, dizziness if ingested
Chronic Exposure Risks: May affect liver and kidney function with long-term or high-dose exposure, potential photosensitivity
Irritation: Can irritate skin, eyes, respiratory tract
Carcinogenicity: No evidence of carcinogenicity in standard tests
Mutagenicity: No significant mutagenic effects in standard in vitro assays
Other Effects: Some risk of allergic reactions in susceptible individuals
Aquatic Toxicity: Harmful to aquatic organisms, possible long-term effects in aquatic environments
Persistence/Degradability: Evidence for limited biodegradability; may persist in surface waters or soil
Bioaccumulation Potential: Low to moderate, but still recommended to prevent environmental release
Mobility in Soil: Moderate; leaching to groundwater possible if not properly contained
Other Effects: Do not allow product, runoff, or waste to contaminate the environment
Waste Disposal: Dispose as hazardous pharmaceutical waste according to local, regional, national standards
Packaging Disposal: Contaminated packaging and spill cleanup materials must be treated as hazardous waste
Sewage Disposal: Do not discharge into drains or natural water bodies
Incineration: Preferred for destruction where permitted
Recycling: Not applicable for this compound; avoid attempting to reclaim drug substance
UN Number: Not classified as dangerous under major transport regulations
Proper Shipping Name: Lomefloxacin Hydrochloride
Hazard Class: Not regulated as hazardous for transport
Packing Group: Not assigned
Special Precautions: Prevent from physical damage, water contact during transport, ensure packaging integrity
Labels: No special labeling required by ADR, IATA, IMDG
Other Transport Requirements: Secure containers to prevent breakage, maintain documents with shipment
US Regulations: Not listed as hazardous by OSHA, SARA Title III, or TSCA; pharmaceutical agents subject to FDA regulation
EU Regulation: Exempt from classification as hazardous under REACH for finished pharmaceuticals
Other Country Requirements: Handled under controlled substance regulations for antibiotics in many regions
Risk Phrases: R22 (Harmful if swallowed), R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Phrases: S24/25 (Avoid contact with skin and eyes), S36/37 (Wear suitable protective clothing and gloves)
