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Product Name: Lisinopril
Chemical Name: (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate
CAS Number: 83915-83-7
Synonyms: Prinivil, Zestril
Product Use: Antihypertensive, treatment of heart failure, management of heart attacks
Manufacturer: Multiple pharmaceutical manufacturers globally, commonly produced as both generic and branded tablets
Contact Information: Refer to packaging for details; pharmacists and poison control provide further resources in emergencies
Emergency Phone: 24-hour poison control centers, hospital emergency departments, or regional health clinics handle accidental exposures
GHS Classification: Not considered a hazardous chemical by GHS criteria for pharmaceutical use in prescribed dosages
Health Hazards: Swallowing excessive amounts may trigger hypotension, dizziness, kidney dysfunction, or allergic reactions; accidental contact with open wounds or mucous membranes may cause minor irritation
Environmental Hazards: Lisinopril in significant quantities may disrupt aquatic life; improper disposal can contribute to pharmaceutical pollution
Label Elements: No pictogram required; warning applies in case of allergic predisposition, pregnancy, or renal compromise
Routes of Exposure: Oral ingestion; inhalation and skin contact considered less problematic in solid form but tablets may crumble to powder
Target Organs: Kidneys, cardiovascular system
Specific Hazards: Not flammable, not explosive, but dust generation should be avoided in large quantities during transport or handling
Main Ingredient: Lisinopril dihydrate (active, therapeutic agent)
Content: Typically 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, or 40 mg per tablet
Excipients: Includes lactose, magnesium stearate, microcrystalline cellulose, starch, calcium phosphate dibasic, iron oxide pigments, croscarmellose sodium, and others depending on manufacturer and formulation
Purity: Pharmaceutical-grade purity (typically >98%)
Impurities: Manufacturing process controls keep recognized impurities below pharmacopoeial limits
Inhalation: Remove individual from dusty area; breathe fresh air; rinse nasal passages if discomfort persists
Skin Contact: Wash thoroughly using soap and plenty of water; check for irritation or rash, seek attention if symptoms persist
Eye Contact: Flush gently with water for at least 15 minutes; remove contact lenses if applicable; get medical attention for redness or persistent symptoms
Ingestion: Rinse mouth out; seek immediate medical assistance especially if medication has not been prescribed or dose is excessive; poisoning symptoms include very low blood pressure, faintness, possible swelling of lips or face
Advice for Physicians: Monitor blood pressure, airway, kidney function; symptomatic treatment; standard supportive care
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, or foam – typical equipment for small-scale pharmaceutical fires
Specific Hazards: Powders or dust in air may form minimal explosive mix in industrial quantities but unlikely in daily use or stock
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, trace organic compounds
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective clothing
Additional Information: Remove containers from affected area if possible, avoid inhaling smoke or fumes
Personal Precautions: Wear gloves, lab coat, safety goggles to avoid direct contact; avoid generating dust; ensure good ventilation
Environmental Precautions: Prevent large spills from reaching water supply or drainage systems; inform appropriate environmental authorities if a significant quantity escapes
Clean-Up Methods: For tablets: pick up mechanically, place in secure disposal bag; for powder: sweep up using moist paper towels or HEPA-filter vacuum, avoid prolonged contact with skin
Disposal: Collect waste in designated hazardous pharmaceutical waste receptacles; labeled according to local and institutional protocols
Handling: Handle using standard procedures for prescription drugs; avoid inhaling dust or crushing tablets unnecessarily; wash hands after use
Storage: Store in a tightly closed original container in cool, dry place (15-30°C/59-86°F); shield from moisture, excessive heat, and direct sunlight; ensure inaccessible to children or unauthorized personnel
Incompatibilities: Keep away from strong acids or bases; avoid mixing with other pharmaceuticals outside prescription regimens
Other Precautions: Rotation and stock control ensure product maintains potency and safety
Engineering Controls: Normal pharmacy or healthcare facility ventilation is sufficient for routine handling; larger-scale handling in compounding or manufacturing requires localized exhaust
Personal Protection: Protective gloves are routine in pharmaceutical workplace; eye protection if crushing or compounding; lab coat or uniform if risk of dust exposure exists
Hygiene Measures: No eating, drinking, or smoking in drug preparation or storage areas; wash hands and exposed skin after use
Exposure Limits: No occupational exposure limit established for lisinopril; minimize exposure where possible; consult local guidelines for pharmaceutical exposure recommendations
Environmental Controls: Prevent bulk waste from entering surface or groundwater
Appearance: White to off-white crystalline powder, typically compressed into scored or coated tablets
Odor: Odorless or faintly medicinal
Molecular Formula: C21H31N3O5·2H2O
Molecular Weight: 441.53 g/mol (as dihydrate)
Melting Point: 174 – 175°C
pH (1% aqueous solution): 7.0 – 8.5
Solubility: Freely soluble in water, practically insoluble in organic solvents like ethanol or acetone
Stability: Chemically stable under recommended storage; sensitive to prolonged exposure to high humidity or temperature
Partition Coefficient (Log Pow): Approximately -2.1 (hydrophilic compound)
Chemical Stability: Stable under standard temperatures and pressures as well as in labeled packaging
Conditions to Avoid: Avoid storing in damp, excessively hot, or in direct sunlight; prevent contamination with incompatible materials
Incompatible Materials: Strong oxidizing agents or acids; avoid extended contact with other reactive pharmaceuticals
Hazardous Decomposition Products: May release oxides of carbon and nitrogen if incinerated
Polymerization: Does not polymerize
Acute Toxicity: Oral LD50 (rat): >90 mg/kg; toxicity in humans associated mostly with overdose, leading to pronounced hypotension, kidney impairment, or angioedema
Chronic Toxicity: Long-term exposure in therapeutic doses considered safe; animal studies show low risk of mutagenicity or carcinogenicity
Routes of Exposure: Swallowing; less commonly by skin or eye contact with powder
Symptoms of Overexposure: Extreme drops in blood pressure, fast or irregular heartbeat, confusion, weakness, swelling of face/hands/feet, or muscle cramps
Allergenic Potential: Possibility of severe reactions (angioedema) in susceptible individuals
Teratogenicity: Not safe during pregnancy; may cause birth defects or loss of pregnancy if given to pregnant women
Additional Data: No significant reproductive toxicity in animals; caution always advised in human therapeutic and handling scenarios
Ecotoxicity: Data limited; possible aquatic toxicity in non-target organisms at high concentrations; unknown potential for chronic ecological effects
Persistence and Degradability: Not rapidly biodegradable; persists in water and soil, standard wastewater treatment procedures may not remove all residues
Bioaccumulative Potential: Not known to bioaccumulate significantly in wildlife
Mobility in Soil: Moderately mobile due to hydrophilic profile
Other Information: Pharmaceutical contamination in waterways can impact drinking water and aquatic life, highlighting the need for responsible disposal
Waste Treatment Methods: Dispose of unused tablets, powders, or solutions through pharmaceutical take-back schemes, as hazardous waste per local regulations
Incineration: Permitted in licensed facilities; avoid open-air burning
Disposal of Containers: Empty packaging handled as regular waste only after all medication removed and destroyed per instructions
Precautions: Never flush down toilets or pour into drains to reduce pharmaceutical pollution
UN Number: Not classified as a dangerous good for land, sea, or air transport
Shipping Name: Lisinopril tablets or powder (non-hazardous material)
Transport Hazard Class: None assigned
Packing Group: None assigned
Environmental Hazards: Not a marine pollutant
Special Precautions: Protect from moisture and extreme temperatures during transit; prevent damage to packaging to avoid accidental spillage
Regulatory Status: Prescription-only medication regulated under national pharmaceutical laws; not an occupational chemical hazard by OSHA, WHMIS, or GHS
Labeling Requirements: Prescription bottle or blister pack must state product name, strength, batch, expiry, patient instructions
TSCA Status: Excluded as a pharmaceutical product
Controlled Substance Status: Not controlled under narcotic or psychoactive drug regulations
SARA Title III: Not listed as hazardous
Other Regulations: Environmental and pharmaceutical waste disposal laws apply at national, state, and institutional levels for both unused drug and manufacturing waste
