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Product Name: Lincomycin Hydrochloride Monohydrate
Chemical Formula: C18H35ClN2O6S·HCl·H2O
CAS Number: 859-18-7
Synonyms: Lincomycin HCl, Linco-Spectin
Recommended Use: Pharmaceutical raw material, veterinary medicine, antibiotic agent
Manufacturer: [Manufacturer information supplied as per regulation requirements, usually listed on packaging or batch certificate]
Contact Information: Emergency phone numbers, technical support phone, and address required for regulatory compliance from the original supplier.
GHS Classification: Sensitization, skin (Category 1); Specific target organ toxicity; Acute toxicity, oral (Category 4); Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; may cause allergic skin reaction; causes serious eye irritation
Pictogram: Exclamation mark as per GHS standard
Precautionary Statements: Wear eye protection, gloves, avoid skin and eye contact, do not eat, drink, or smoke when handling
Potential Health Effects: May trigger allergic reactions in sensitive individuals; repeated or prolonged contact causes skin and eye irritation
Chemical Name: Lincomycin Hydrochloride Monohydrate
Concentration: ≥97.0% active ingredient
Impurities: Residual solvents and moisture content below 1% combined, as per pharmaceutical monographs
Inactive Ingredients: None reported; mono-component substance in typical preparations
Inhalation: Move to fresh air, keep patient warm and at rest, seek medical attention if symptoms continue (e.g., coughing, difficulty breathing)
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and non-abrasive soap, medical attention if rash or irritation persists
Eye Contact: Rinse immediately with clean running water for at least 15 minutes, remove contact lenses if present, seek prompt medical help
Ingestion: Rinse mouth with water but do not induce vomiting, seek immediate medical attention; provide product packaging or identification to responders
Most Important Symptoms: Respiratory irritation, skin allergy, eye discomfort, nausea on ingestion in sensitive individuals
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical powder
Special Hazards: Emission of toxic and irritating fumes (e.g., nitrogen oxides, sulfur compounds, hydrogen chloride) during combustion
Firefighter Instructions: Wear self-contained breathing apparatus and full protective gear, avoid inhaling combustion gases, evacuate non-essential personnel from vicinity
Explosion Data: No known explosive properties but powders may form combustible dust-air mixtures
Personal Precautions: Wear chemically resistant gloves, protective clothing, goggles, and dust mask or respirator
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid contamination of soil and waterways
Cleanup Methods: Scoop up carefully, avoiding dust generation, place in suitable container for disposal; ventilate area and wash site of spillage with detergent and water; collect washings for proper disposal
Decontamination: Rinse with copious amounts of water and clean all tools used
Handling: Use in powder handling cabinet or well-ventilated area, keep containers tightly closed, avoid breathing dust or direct skin contact, wash hands before breaks and after work
Storage: Store in cool, dry, well-ventilated area away from incompatible substances such as oxidizers or strong acids, keep away from heat and moisture sources, secure against unauthorized access
Special Storage Requirements: Use polyethylene or glass containers preferred; do not store with foodstuffs or animal feed; keep away from children and pets
Shelf Life: Check expiration date as per suppliers. Loss of potency and stability beyond stated shelf life.
Exposure Limits: No official occupational exposure limits set for Lincomycin Hydrochloride; prudent practice recommends minimal dust exposure (use local exhaust ventilation/cabinet)
Engineering Controls: Fume hood or powder handling station for significant quantities; avoid recirculation of dust-laden air
Personal Protective Equipment: Nitrile or latex gloves, chemical splash goggles, long-sleeved lab coat or overalls, P2 or higher-rated respiratory protection if powder is airborne
Hygiene Measures: Wash hands, forearms, and face thoroughly before eating and after handling, avoid hand-to-mouth contact during use
Form: White to off-white crystalline powder
Odor: Slight or none
pH: 3.0 – 5.0 (1% aqueous solution)
Melting Point: 150°C – 156°C (decomposition)
Solubility in Water: Freely soluble
Vapor Pressure: Not significant under ambient conditions
Density: Roughly 1.3 g/cm³
Partition Coefficient (log Kow): Data unavailable, but expected to be low due to water solubility
Other Properties: Hygroscopic; light sensitive; tends to cake in humid conditions
Chemical Stability: Stable under recommended storage conditions; decomposes on heating or exposure to strong acids/bases
Reactivity: No hazardous polymerization reported; reacts with oxidizing agents
Conditions to Avoid: Excessive moisture, prolonged exposure to light, high temperatures
Hazardous Decomposition: Nitrogen oxides, sulfur oxides, hydrogen chloride gas in fire conditions
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral rat LD50 >4000 mg/kg; low acute oral toxicity but medical monitoring advised due to allergic potential
Chronic Toxicity: Prolonged or repeated exposure may sensitize skin, cause respiratory or skin allergies; target organ effects rare but documented as liver and kidney issues for susceptible individuals
Irritation: Causes eye and skin irritation on contact
Sensitization: Allergic reactions can occur in sensitive persons—including rashes, asthma-like symptoms, or anaphylaxis in rare cases
Additional Information: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity detected in animal studies at therapeutic doses
Ecotoxicity: Antibiotics present environmental concern due to persistence and impacts on microbial communities; can harm aquatic organisms at high concentrations
Persistence and Degradability: Moderately persistent; breakdown in environment requires specialized bacteria
Bioaccumulative Potential: Not considered bioaccumulative
Mobility in Soil: High solubility increases risk of leaching to groundwater
Other Adverse Effects: Prolonged chemical release contributes to development of antibiotic resistance in the environment
Waste Disposal Methods: Dispose in accordance with local, state, and federal environmental regulations; do not discharge to natural waterways or sewerage
Contaminated Packaging: Rinse containers, dispose safely through licensed chemical waste disposal contractor
Small Quantity Disposal: Can be mixed with absorbent material and sent to landfill where permitted, supervised by trained waste personnel
Precautions: Prevent accidental exposure to waste handlers, documentation for traceability recommended
UN Number: Not assigned
UN Proper Shipping Name: Not regulated for ground, air, or maritime transport in most countries
Transport Hazard Class: Not classified as a dangerous good
Packing Group: Not required
Environmental Hazards: Not classified as hazardous to the environment under international transport regulations
Special Precautions: Package to avoid generating dust and preventing moisture ingress during transit, label containers properly for identity and handling information
Inventory Status: Listed in main chemical inventories (TSCA, EINECS, DSL, AICS, NZIoC, etc.) depending on jurisdiction
Federal Regulations: Subject to drug, antibiotic, or hazardous substance regulations in some regions; veterinary usage must conform to local prescription requirements
Labeling Requirements: Clear identification, hazard pictograms, and precautionary measures required on workplace labels
Other Regulatory Status: Use restrictions may apply in food-producing animals or agricultural settings; consult applicable country-specific guidelines
Worker Protection: Training and safe work standards expected under occupational safety laws
