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Product Name: Lesinurad
Chemical Name: Lesinurad
Synonyms: RDEA594
CAS Number: 878672-00-5
Recommended Use: Pharmaceutical intermediate, uric acid reabsorption inhibitor
Manufacturer: Registered pharmaceutical supplier
Emergency Contact: See local emergency health provider
Classification: Eye irritation, skin sensitizer, specific target organ toxicity-single exposure
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, use in a well-ventilated area, wash thoroughly after handling
Physical Hazards: Dust can form explosive mixtures in air, irritation to skin and eyes
Environmental Hazards: Potentially harmful to aquatic organisms with long-lasting effects
GHS Label Elements: Exclamation mark symbol
Chemical Identity: Lesinurad
Purity: ≥98%
Impurities: Less than 2%, mostly process-related chemicals
Molecular Formula: C17H14BrN3O2S2
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses, seek immediate medical advice
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, consult a doctor if irritation persists
Inhalation: Move person to fresh air, provide artificial respiration if needed, seek medical attention
Ingestion: Rinse mouth thoroughly, do not induce vomiting, seek immediate medical care
Notes for Physicians: Monitor for symptoms of respiratory distress or allergic reaction
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder or foam
Unsuitable Extinguishing Media: Avoid high-pressure water streams
Specific Hazards: Emission of toxic fumes under fire conditions, forms hazardous carbon oxides, nitrogen oxides, sulfur and bromine compounds
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Special Precautions: Avoid inhaling smoke, contain run-off to prevent environmental contamination
Personal Precautions: Use personal protective equipment, avoid dust generation, avoid contact with eyes and skin
Emergency Procedures: Evacuate unnecessary personnel, ventilate area, wear NIOSH-approved respirator
Containment: Avoid release into drains, contain spillage using non-combustible absorbent material
Cleanup: Sweep up and transfer to sealed container for proper disposal, wash spill area with water
Handling: Use only in well-ventilated environments, minimize dust generation, wear suitable protective equipment
Safe Storage: Store in cool, dry, well-ventilated location away from light, incompatible materials include strong oxidizers, acids, and bases
Storage Conditions: Keep tightly sealed in original packaging, protect from moisture
Sensitive To: Light, humidity
Engineering Controls: See that local exhaust ventilation is used, employ mechanical ventilation for dust control
Personal Protective Equipment: Safety glasses, nitrile gloves, laboratory coat
Respiratory Protection: NIOSH-approved respirator if dust becomes airborne
Exposure Limits: No established occupational exposure limits for Lesinurad
Hygiene: Wash hands before breaks, after handling, and at end of shift
Appearance: Off-white to pale yellow powder
Odor: Odorless
Odor Threshold: Not available
pH: Not determined
Melting Point: 214-218°C
Boiling Point: Decomposes before boiling
Flash Point: Data unavailable
Evaporation Rate: Not relevant (solid)
Flammability: Not considered flammable, but dust can form explosive mixtures
Vapor Pressure: Negligible
Vapor Density: Not applicable
Solubility: Slightly soluble in water, soluble in DMSO and methanol
Partition Coefficient: log P value approximately 2.3
Auto-Ignition Temperature: Data not available
Decomposition Temperature: >200°C
Chemical Stability: Stable when stored under recommended conditions
Reactivity: No dangerous reactions expected under normal use
Hazardous Reactions: Reacts with strong oxidizing agents, acids, bases
Conditions to Avoid: Excessive heat, light, moisture
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur compounds, bromine compounds
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Low oral toxicity in animal studies, may cause irritation to respiratory tract and digestive system
Skin Sensitization: Causes irritation, potential for allergic reactions in sensitive individuals
Eye Contact: Causes redness, pain, tearing
Chronic Exposure: No evidence for carcinogenicity or mutagenicity
Teratogenicity: Not established for humans
LD50: Animal LD50 (oral, rat) > 2,000 mg/kg
Ecotoxicity: Harmful to aquatic organisms, risk of long-term adverse effects in the aquatic environment
Persistence and Degradability: Poorly biodegradable, tends to persist in soil and water
Bioaccumulation Potential: Low based on chemical structure and available data
Mobility in Soil: Expected to exhibit limited mobility
Other Adverse Effects: Avoid release to the environment, collect spillages
Waste Treatment Methods: Dispose of contents and container according to local regulations, incinerate in permitted facility
Hazardous Waste: Classified as hazardous due to ecotoxicological properties
Contaminated Packaging: Rinse containers, manage as chemical waste
Special Precautions: Avoid landfill disposal, do not release into waterways
UN Number: Not assigned
UN Proper Shipping Name: Not regulated for transport
DOT (US): Not regulated as a hazardous material
IMDG Code: Not hazardous for sea transport
IATA: Non-regulated for air transport
Special Transport Precautions: Protect against physical damage, avoid temperature extremes
OSHA Status: Not regulated as hazardous
TSCA Inventory: Not listed
SARA Title III: Not designated as a reportable material
EU Regulations: Not subject to classification under CLP Regulation
REACH Status: Not registered
WHMIS Classification (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Other Regulatory Listings: Detailed submission to national authorities required for commercial pharmaceutical use
