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Product Name: Lenvatinib Mesylate
Synonyms: Lenvatinib methanesulfonate
Chemical Formula: C21H19ClN4O4 • CH4O3S
CAS Number: 857890-39-2
Manufacturer: Pharmaceutical producers specializing in TKIs
Recommended Uses: Oncology research, targeted cancer therapy
Contact Information: Emergency telephone numbers provided by manufacturers and local poison control centers
Classification: Acute Toxicity Oral – Category 3; Specific Target Organ Toxicity – Category 2
Signal Word: Danger
Hazard Statements: Toxic if swallowed; May cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, Health hazard
Precautionary Statements: Use with protective gloves, avoid ingestion or skin contact, wash hands thoroughly after handling, keep out of reach of non-professionals
Routes of Exposure: Oral, dermal, inhalation
Symptoms: Headache, nausea, abdominal pain, fatigue, vomiting, loss of appetite
Chemical Name: Lenvatinib Mesylate
Percent Composition: Pure API content typically >98%
Impurities: Trace amounts <2% chemically related compounds
Additives: Absent (bulk raw material)
CAS Number: 857890-39-2
EC Number: No assigned EC number
Molecular Weight: 522.92 g/mol (with mesylate)
Eye Contact: Immediately rinse with plenty of water for 15 minutes, lift eyelids to expose all surfaces, seek medical advice promptly
Skin Contact: Remove contaminated clothing, wash skin with soap and water, if irritation or other symptoms develop consult a medical professional
Inhalation: Remove from exposure area to fresh air, keep person warm and at rest, consult a health professional if respiratory symptoms appear
Ingestion: Rinse mouth with water, do not induce vomiting unless told by a professional, consult poison control or a physician immediately
Most Important Symptoms: Gastrointestinal disturbance, rash, dizziness, blood pressure changes
Note to Physician: Symptomatic treatment; monitor vital signs; consider supportive care for overdose
Suitability of Extinguishing Media: Dry chemical powder, carbon dioxide, foam; avoid high-pressure water jet directly on the substance
Unsuitable Extinguishing Media: Direct high-volume water spray
Specific Hazards: Emits toxic fumes under fire conditions (oxides of carbon, nitrogen, sulfur)
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Fire/Explosion Hazards: Combustible dust may form explosive mixtures with air; avoid creating dust clouds
Special Procedures: Contain fire-fighting water to prevent environmental release; ventilate area after extinguishing fires
Personal Precautions: Use appropriate PPE, prevent contact with skin and eyes, avoid generating airborne dust
Environmental Precautions: Prevent release into drains, surface water, or soil; notify authorities if large quantities enter environment
Cleanup Methods: Carefully sweep or scoop up material, place in suitable closed container for disposal, wash area with water and mild detergent
Spill Response: Limit spread with absorbent materials (e.g., vermiculite), ventilate area, avoid raising dust, decontaminate with soap and water
Precautions for Safe Handling: Handle in well-ventilated areas, wear PPE (gloves, mask, goggles), minimize dust generation, avoid inhalation or ingestion
Incompatible Materials: Strong oxidizing agents
Hygiene Measures: Wash thoroughly after handling, do not eat, drink, or smoke in storage or work area
Storage Conditions: Store at room temperature (15-25°C), in original tightly-closed container, away from direct sunlight and moisture
Segregation: Keep apart from incompatible or reactive chemicals; secure storage location with limited access
Engineering Controls: Use fume hood or local exhaust ventilation, maintain negative pressure room if possible
Occupational Exposure Limits: No established limits for this specific molecule
Eye Protection: Chemical splash goggles
Skin Protection: Impermeable gloves (nitrile or latex), lab coat, closed footwear
Respiratory Protection: NIOSH-certified dust mask or respirator in cases of dust formation
Work Practices: Avoid direct contact, regularly clean work surfaces, use disposable bench paper, and avoid hand-to-face contact in the lab
Appearance: White or off-white crystalline powder
Odor: Practically odorless
Odor Threshold: Not determined
pH (1% sln): Not available
Melting Point: Estimated 207-210°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable
Flammability: Not classified as flammable, but may contribute to fine combustible dust
Vapor Pressure: Negligible
Solubility: Slightly soluble in water, soluble in DMSO and methanol
Partition Coefficient (log Pow): Not determined
Density: Approx. 1.4 g/cm³
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal handling conditions
Possibility of Hazardous Reactions: No dangerous reactions known under normal use
Conditions to Avoid: Excessive heat, uncontrolled dust generation, exposure to strong light
Incompatible Materials: Strong oxidizers, acids, and bases
Decomposition Products: Oxides of carbon, nitrogen, sulfur, other potentially hazardous organics
Routes of Exposure: Oral, skin contact, inhalation
Acute Toxicity: High oral toxicity; LD50 in animals (rats) reported between 50-300 mg/kg
Chronic Toxicity: May cause liver, kidney, or gastrointestinal tract damage with repeated exposure
Carcinogenicity: Not listed by IARC or OSHA
Reproductive Effects: Animal studies suggest potential for reproductive and fetal toxicity
Mutagenicity: Some evidence for mutagenicity in in vitro tests
Symptoms: Headache, fatigue, dizziness, hypertension, proteinuria, abdominal pain
Sensitization: May cause allergic reactions in sensitive individuals
Ecotoxicity: Harmful to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Expected to be persistent in natural waters, low biodegradability
Bioaccumulative Potential: Not significantly bioaccumulative due to low log Kow values
Mobility in Soil: Moderate mobility, risk for groundwater contamination
Other Adverse Effects: Unintentional release may disrupt local microbial or aquatic life
Disposal Methods: Handle as hazardous pharmaceutical waste; incinerate in approved facility
Container Disposal: Triple-rinse, then puncture and dispose according to local regulations
Contaminated Packaging: Treat as hazardous waste, consult specialist disposal contractor
Waste Codes: Consult local, regional, or national legislation for proper code assignment
Precautions: Avoid environmental release, do not flush into sewers or waterways
UN Number: Not assigned for this compound
UN Proper Shipping Name: Not regulated—not classified as a hazardous substance for transport under international conventions
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: Potential aquatic toxicity
Special Precautions: Ship in leak-proof containers, segregate from foodstuffs and animal feeds, ensure secure labeling
Global Inventory Status: Not listed in AICS, DSL, EINECS, or TSCA inventories
OSHA Status: Not regulated as a hazardous material under the OSHA Hazard Communication Standard
EU REACH: Registration not required for pharmaceutical research substances under Annex IV/V
SARA/Title III: Not subject to specific reporting
WHMIS Classification (Canada): Not required for clinical finished products, but considered hazardous as a pure powder
Other Local Regulations: Must comply with applicable pharmaceutical waste regulations and worker safety standards in country of use, including keeping documentation on file
