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Product Name: Laurocapram
Synonyms: 1-Dodecylazacycloheptan-2-one, Azone
CAS Number: 59227-89-3
Recommended Use: Penetration enhancer for pharmaceuticals and cosmetics, research chemical
Supplier: Chemical supplier or manufacturer as listed on packaging
Contact Information: Refer to product label for emergency telephone number and responsible party
UN Number: Not classified as hazardous for transportation
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Environmental hazard (Aquatic Chronic 3)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, Harmful to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing vapors, Wear protective gloves and eye protection, Wash hands thoroughly after handling, Avoid release to the environment
Pictograms: Exclamation mark, Environmental hazard
Chemical Name: Laurocapram
CAS Number: 59227-89-3
Concentration: >98% by weight
Impurities: Minor acyclic homologues or byproducts not known to affect safety under normal use
Inhalation: Move exposed person to fresh air, keep at rest, seek medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water or shower for at least 15 minutes, consult doctor if irritation persists
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, consult a physician
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Most important symptoms/effects: Redness, irritation, possible allergic reaction, no specific chronic effects known at this time
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide
Unsuitable Extinguishing Media: High-volume water jet can spread burning liquid
Specific Hazards: Combustion can produce irritating fumes, carbon oxides, nitrogen oxides
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, protective clothing
Firefighting Instructions: Keep containers cool with water spray, prevent runoff from entering drains
Personal Precautions: Use personal protective equipment, avoid contact with eyes and skin, ventilate area
Environmental Precautions: Prevent further leakage or spillage if safe, avoid discharge into environment, do not flush into surface water
Methods for Containment: Cover with inert absorbent material, sweep up, keep in suitable closed containers for disposal
Cleanup Procedures: Clean contaminated floors with plenty of water, ventilate space thoroughly afterward
Handling: Avoid contact with skin, eyes and clothing, do not breathe vapor or mist, use with adequate ventilation, wash hands before breaks and at end of work
Storage: Store tightly closed in a cool, dry, well-ventilated place, keep away from incompatible materials like strong oxidizers and acids, protect from excessive heat and direct sunlight
Recommended Packaging: Use original packaging or compatible chemical-resistant containers
Occupational Exposure Limits: No specific OSHA or ACGIH exposure limits established
Engineering Controls: Use with local exhaust ventilation or in chemical fume hood
Personal Protective Equipment: Protective gloves (nitrile recommended), safety goggles, laboratory coat, use respiratory protection in case of insufficient ventilation
General Hygiene Measures: Avoid eating, drinking, or smoking in areas where chemical is handled, wash hands thoroughly after use
Appearance: Colorless or slightly yellowish oil
Odor: Faint characteristic scent
Molecular Formula: C18H35NO
Molecular Weight: 281.48 g/mol
Melting Point: -22°C
Boiling Point: 192-195°C at 2 mmHg
Flash Point: >100°C (estimate, not highly flammable)
Solubility: Insoluble in water, soluble in organic solvents including ethanol, acetone, oils
Vapor Pressure: Low at room temperature
Density: 0.93–0.95 g/cm³ at 20°C
pH: Not applicable (neutral compound)
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Strong heat, sources of ignition, contact with strong oxidizing agents
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, irritating fumes
Potential for Polymerization: Will not polymerize under normal conditions
Routes of Exposure: Skin, eyes, ingestion, and inhalation
Acute Toxicity: Low acute toxicity based on available data; limited animal studies show high LD50 (>2000 mg/kg oral, rat)
Skin Irritation: Causes moderate irritation after prolonged or repeated contact
Eye Irritation: Can cause redness or stinging
Respiratory Effects: Minor irritation, only at high vapor concentrations
Sensitization: Not expected, but some individuals may develop mild contact dermatitis
Chronic Exposure: No data on carcinogenicity, mutagenicity, or reproductive toxicity found in existing studies
Long-term Effects: No cumulative toxicity reported under controlled use
Ecotoxicity: Harmful to aquatic organisms with prolonged exposure, possible bioaccumulation in aquatic systems
Persistence and Degradability: Slowly biodegradable in soil and water, breaks down over weeks to months
Bioaccumulation Potential: Moderate, high log Kow suggests potential for concentration in aquatic species
Mobility in Soil: Low water solubility reduces mobility, substance may adhere to sediment
Other Adverse Effects: Avoid uncontrolled environmental release
Disposal Methods: Dispose in accordance with local, regional, and national regulations; incinerate in approved facility, use licensed chemical waste disposal company
Contaminated Packaging: Treat as hazardous waste, recycle if possible or dispose as per chemical waste guidelines
Disposal Precautions: Avoid release to environment, do not drain to open water bodies or soil
UN Number: Not regulated for ground, air, or sea transport
Proper Shipping Name: Not classified as hazardous for transport
Hazard Class: None required
Packing Group: None
Marine Pollutant: No – but precaution suggested due to aquatic toxicity
Special Precautions: Transport in closed containers, keep away from food and feed, follow local regulations for chemical transport
US Regulations: Not listed in TSCA, CERCLA, SARA Title III Section 302/304/311/312/313
EU Regulations: Not listed as a hazardous substance under REACH Annex XIV or XVII, may require registration for industrial use
Canada (DSL/NDSL): Check local Canadian chemical substance inventories
Labeling Requirements: Refer to GHS, use appropriate pictograms, hazard and precautionary statements
Other International: Not classified as a controlled substance by major global chemical control regimes
