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Material Safety Data Sheet (MSDS) for Lactoferrin

Identification

Product Name: Lactoferrin
Chemical Name: Lactoferrin
CAS Number: 146897-68-9
Recommended Use: Dietary supplement, ingredient in infant formula, pharmaceutical applications
Manufacturer: Supplier information available upon request
Contact Phone Number: Listed with manufacturer or distributor
Emergency Phone: Provided by local distributor
Synonyms: Laktoferrin, Milk Iron-Binding Protein
Product Code: Provided by manufacturer

Hazard Identification

Classification: Not classified as hazardous under GHS standards; considered non-hazardous under normal conditions
Label Elements: No pictogram required
Signal Word: None
Hazard Statements: May cause minor respiratory irritation if dust is inhaled; ingesting large quantities might upset stomach; slight risk of skin or eye irritation with direct contact
Precautionary Statements: Avoid dust formation; use with adequate ventilation; wash hands after handling
Other Hazards: No known significant immediate risks beyond routine hygiene concerns

Composition / Information on Ingredients

Substance: Pure Lactoferrin
Concentration: ≥95% (w/w) as active protein
Impurities: Trace minerals, carbohydrates, less than 5% other milk-derived proteins
Additives: None reported
Formula: C1416H2232N386O394S19 (approximate for protein chain)

First Aid Measures

Inhalation: Remove to fresh air; seek medical attention if breathing becomes difficult
Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; seek medical guidance for irritation
Ingestion: Rinse mouth with water; drink water to dilute; obtain medical aid in case of discomfort
Symptoms/Effects: Coughing, sneezing from dust, mild irritation possible; typically resolves with supportive measures

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: Not determined; avoid strong water jets
Specific Hazards: Combustion may release oxides of carbon, nitrogen compounds
Protective Equipment: Standard firefighting PPE, self-contained breathing apparatus for enclosed spaces
Advice for Firefighters: Move containers away from fire zone if safe; prevent runoff entering waterways

Accidental Release Measures

Personal Precautions: Avoid breathing in dust; ventilate area; wear protective gloves, dust mask, goggles
Environmental Precautions: Do not allow large quantities to enter drains or waterways
Cleaning Methods: Sweep up and place in appropriate container for disposal; wash area with plenty of water to remove residue; avoid creating airborne dust

Handling and Storage

Handling: Use with adequate ventilation; avoid generating dust; wear suitable PPE
Hygiene Practices: Wash hands before eating or drinking; keep work area clean
Storage Conditions: Store in tightly closed container, away from moisture and direct sunlight; recommended storage temperature 2–8°C for longest shelf life
Incompatibilities: Strong acids, strong bases, oxidizing agents; minimize exposure to reactive chemicals
Specific Storage Requirements: Keep apart from food and feed in bulk; ensure containers are sealed to prevent contamination

Exposure Controls / Personal Protection

Exposure Limits: No occupational exposure limit values listed
Engineering Controls: Local exhaust ventilation in areas with significant dust production
Personal Protective Equipment (PPE): Safety glasses, dust mask or particulate respirator, disposable gloves, protective clothing in bulk handling
Hygiene Measures: Avoid eating, drinking, or smoking during use; wash hands after handling

Physical and Chemical Properties

Physical State: Fine powder or lyophilized cakes
Color: Light pink, pale tan, or off-white
Odor: Mild, characteristic protein odor
pH (1% Solution): 6.0–8.0
Melting Point: Not applicable (protein denatured before melting)
Boiling Point: Not applicable
Solubility: Soluble in water, forms clear to opalescent solution
Partition Coefficient (n-octanol/water): Not available
Vapor Pressure: Not relevant
Relative Density: 1.3–1.4 g/cm³
Flash Point: Not relevant
Decomposition Temperature: >80°C (thermal degradation of protein)
Viscosity: Not relevant

Stability and Reactivity

Chemical Stability: Stable under recommended conditions; prolonged exposure to heat and humidity will degrade protein
Conditions to Avoid: Moisture, high temperatures, direct sunlight, exposure to acids and oxidizers
Materials to Avoid: Strong acids, strong alkalis, oxidizing agents
Reactivity: Not reactive with most common substances under ambient conditions
Decomposition Products: Oxides of carbon, nitrogen compounds, sulfur oxides in fire
Hazardous Polymerization: Will not occur

Toxicological Information

Acute Toxicity: No data suggesting significant acute toxicity; generally recognized as safe (GRAS) in food use
Chronic Toxicity: Long-term effects not observed at reasonable levels for human use
Routes of Exposure: Inhalation of dust, skin/eye contact, ingestion
Skin Corrosion/Irritation: Minimally irritating in sensitive individuals
Eye Damage/Irritation: Slight irritation possible if particles enter eyes
Respiratory Effects: Dust may cause coughing or mild throat irritation in sensitive people
Carcinogenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: No evidence of adverse reproductive or developmental effects
Mutagenicity: No mutagenic effects reported
Occupational Disease Potential: No known associated conditions if handled properly

Ecological Information

Ecotoxicity: Not known to exert harmful effects on aquatic or terrestrial organisms
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulation Potential: Does not bioaccumulate
Mobility in Soil: Easily broken down, low mobility expected
Other Adverse Effects: No significant ecological impact anticipated at normal usage volumes

Disposal Considerations

Waste Disposal: Dispose of unused material in general waste according to local regulations
Contaminated Packaging: Rinse and dispose of as per local waste regulations or recycle if appropriate
Special Precautions: Prevent large amounts from entering drains, surface water, or groundwater systems

Transport Information

UN Number: Not classified as a hazardous material
UN Proper Shipping Name: Lactoferrin (non-hazardous)
Transport Hazard Class: Not regulated
Packing Group: Not applicable
Environmental Hazards: None
Special Precautions for User: Prevent package damage during transit; keep container tightly sealed and dry
Transport in Bulk: Allowed under standard food ingredient transport requirements

Regulatory Information

U.S. Regulations: FDA GRAS status for some applications
EU Regulations: Approved as food additive and infant formula component under specified conditions
Other International Regulations: Subject to national legislation for food, pharmaceutical, or cosmetic use
TSCA Listing: Not required
REACH Status: Exempt for substances of natural origin under certain volumes and uses
Workplace Regulation: No mandatory workplace exposure limits
Labeling Requirements: Comply with food labeling laws when used in consumable products
SDS Availability: Provided to downstream users and upon request according to regional regulations