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Product Name: L-Tyrosine
Chemical Name: 4-Hydroxy-L-phenylalanine
CAS Number: 60-18-4
Molecular Formula: C9H11NO3
Molecular Weight: 181.19 g/mol
Synonyms: L-2-Amino-3-(4-hydroxyphenyl)propanoic acid, Tyrosine
Recommended Use: Nutritional supplement, amino acid source, biochemical reagent
Supplier Details: Company contact and emergency phone number supplied per local regulation, specific information available from manufacturer or distributor
Emergency Contact: Emergency phone numbers provided through workplace safety programs or product packaging
Classification: Not classified as hazardous according to OSHA Hazard Communication Standard (29 CFR 1910.1200) and EU Regulation (EC) No 1272/2008
Label Elements: No pictogram, signal word, or hazard statement required under GHS
Potential Health Effects: Ingestion can cause nausea or abdominal discomfort in some cases. Inhalation may be irritating to the respiratory tract. Prolonged contact with skin or eyes rarely triggers irritation. Always maintain good lab practice.
Environmental Hazards: No significant hazards for the environment expected under proper handling and disposal conditions
Special Note: Large quantities or dust may aggravate asthma or respiratory conditions in sensitive individuals
Chemical: L-Tyrosine
Purity: ≥98% (industry standard for supplements and research products)
Hazardous Components: No hazardous ingredients present above threshold amounts
Impurities/Additives: Trace process materials or by-products may occur below regulatory concern level, certificate of analysis available from supplier
General Advice: Move affected person away from exposure and into fresh air. Seek medical attention in case of persistent discomfort.
Inhalation: Move person to fresh air. Help with breathing as necessary. If symptoms develop or persist, get medical help.
Skin Contact: Remove contaminated clothing. Wash skin with plenty of soap and water. If irritation develops, consult a physician.
Eye Contact: Rinse thoroughly with water for several minutes, lifting upper and lower eyelids. Remove contact lenses if possible. Seek further medical care if symptoms remain.
Ingestion: Rinse mouth with water. Drink water to dilute. Seek medical advice if feeling unwell.
Protection of First Aid Responders: Use gloves and standard personal protection. Avoid powder inhalation or contact with eyes during first aid.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide (CO₂). Do not use high-pressure water streams.
Specific Hazards: May release irritating or toxic vapors such as nitrogen oxides and carbon oxides during combustion.
Protective Equipment: Wear self-contained breathing apparatus (SCBA) and full protective clothing to prevent contact with skin and eyes.
Firefighting Procedures: Approach fire from upwind to avoid hazardous vapors and stay clear of the area if not involved in firefighting.
Personal Precautions: Avoid dust formation. Wear suitable personal protective equipment—gloves, goggles, dust mask or respirator when dust may be generated.
Environmental Precautions: Prevent spilled material from entering drains, surface water, or soil.
Methods for Cleanup: Scoop or sweep solid powder with care to avoid dusting. Collect in a properly labeled waste disposal container.
Spill Response: Clean thoroughly with water and detergent after solid is removed. Dispose of according to regulations.
Precautions for Safe Handling: Handle in a well-ventilated area. Avoid breathing dust. Use local exhaust ventilation or work under a chemical fume hood.
Safe Storage Conditions: Store in tightly closed container, in a cool, dry, and well-ventilated place. Keep away from incompatible substances such as strong oxidizers.
Special Packaging Requirements: Use containers made of compatible materials, clearly labeled with product name and hazard information as required.
Hygiene Recommendations: Wash hands before breaks and after handling. Keep food, drink, and tobacco away from storage and use areas.
Occupational Exposure Limits: No OSHA or ACGIH exposure limits specified for L-Tyrosine. Use good hygiene practice and engineering controls to minimize airborne dust.
Engineering Controls: Use adequate general and local exhaust ventilation. Powder handling facilities, like those in compounding labs, benefit from HEPA filtration.
Personal Protective Equipment: Safety goggles, lab coat, disposable gloves (nitrile, latex), and a dust respirator or mask if powder may become airborne.
Environmental Exposure Controls: Procedures for spill prevention and proper ventilation reduce environmental exposure risk.
Appearance: White to off-white crystalline powder
Odor: Slight, characteristic
Odor Threshold: No data available
pH: 5.0–7.0 (1% solution in water)
Melting Point/Range: 343 °C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable under normal conditions
Vapor Pressure: Not relevant
Vapor Density: Not relevant
Solubility: Slightly soluble in water; insoluble in ethanol, acetone, ether
Partition Coefficient (log Kow): -2.26
Decomposition Temperature: Decomposes at high temperature, emitting smoke and irritating gases
Viscosity: Not relevant
Chemical Stability: Stable under recommended storage conditions
Reactivity: No specific reactivity hazards identified
Conditions to Avoid: Exposure to moisture, excessive heat, open flames, strong oxidizers
Incompatible Materials: Strong acids, strong oxidizing agents (cause potential degradation or fire risk)
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, smoke may form under fire or decomposition
Polymerization: Will not occur
Acute Toxicity: Low toxicity reported. LD50 (oral, rat): > 5000 mg/kg
Inhalation: Dust may irritate nose and throat. Symptoms include coughing or sneezing.
Skin Contact: Likely no irritation, but repeated, prolonged exposure may cause mild discomfort in rare cases.
Eye Contact: May cause mild irritation, redness or watering on contact.
Chronic Effects: No data indicating chronic toxicity or carcinogenicity. Not listed as a carcinogen by IARC, NTP, OSHA.
Target Organs: No specific target organ effects noted from occupational exposure.
Sensitization: Not known to trigger allergic reactions in contact or inhalation studies.
Mutagenicity/Genotoxicity: No evidence found in available literature.
Ecotoxicity: Not expected to be harmful to aquatic or terrestrial organisms at normal concentrations.
Persistence and Degradability: Readily biodegradable, does not persist in the environment.
Bioaccumulative Potential: Low, does not accumulate in biological systems.
Mobility in Soil: Water solubility allows some mobility, but unlikely to migrate significantly due to partial degradation.
Other Adverse Effects: No evidence of ozone depletion, endocrine disruption, or long-term environmental impact.
Waste Disposal Methods: Dispose of unfinished product, unused contents, and contaminated items as non-hazardous chemical waste in accordance with federal, state, and local regulations.
Sewage Disposal: Do not release large quantities into sewers or waterways.
Packaging Disposal: Clean and recycle or dispose of packaging as required by local waste authorities.
Special Precautions: Follow all applicable guidelines for chemical waste in laboratory or production settings.
UN Number: Not classified as hazardous for transport.
UN Proper Shipping Name: Not regulated.
Transport Hazard Class: Not regulated or classified for hazard.
Packing Group: Not regulated.
Marine Pollutant: No
Special Transport Precautions: Ship in tightly sealed containers to prevent spoilage; keep away from food and drink.
Labels: No hazard label required during transport.
Safety, Health, and Environmental Regulations: L-Tyrosine appears on U.S. TSCA inventory and EU EINECS (EC No 200-460-4). Does not qualify for specific workplace hazard under OSHA, CLP, or WHMIS.
Other Inventories: Listed in Australia AICS, Canada DSL/NDSL, Japan ENCS, Korea KECI, China IECSC, and New Zealand NZIoC.
SARA/Title III Hazard Categories: Not reportable under SARA 302, 304, 313.
California Proposition 65: Not listed.
Right-to-Know Listings: Not listed under New Jersey, Pennsylvania, or Massachusetts RTK requirements.
Workplace Labeling: Containers require standard workplace labeling in accordance with OSHA or EU CLP rules, including product identity and supplier information.
