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Product Name: L-Methionine
Chemical Formula: C5H11NO2S
CAS Number: 63-68-3
Synonyms: 2-Amino-4-(methylthio)butyric Acid
Use: Nutritional supplement, animal feed additive, laboratory reagent
Manufacturer Contact: Emergency phone number and full address required here for complete traceability and compliance with safety regulations.
Recommended Restrictions: For industrial use and laboratory research only, not for drug, food, or household purposes.
Hazard Classification: Not classified as hazardous under GHS criteria
Physical Hazards: Can form dust clouds if handled in bulk, which pose combustible dust risks
Health Hazards: May cause mild irritation to respiratory tract, eyes, or skin after lengthy exposure; not considered acutely toxic
Environmental Hazards: Potential for local aquatic toxicity if large amounts enter waterways
Label Elements: No pictogram required; precautionary statements focus on dust control and good hygiene practice during handling
Chemical Identity: L-Methionine
Concentration: >98% (commercial/technical grade)
Impurities/Additives: Trace levels of other amino acids or inert materials, can vary by provider; purity must support both efficacy and safety for feed or supplement grades
Inhalation: If dust is inhaled, move individual to fresh air and keep at rest; stomach upset or mild throat irritation can clear quickly with fresh air
Skin Contact: Wash skin thoroughly with water; in case of redness, seek further medical attention
Eye Contact: Rinse with plenty of water for several minutes; remove contact lenses if present and easy to do
Ingestion: Rinse mouth with water, give water to drink, seek medical aid if symptoms appear unusual or do not resolve
Suitable Extinguishing Media: Water spray, dry powder, foam, or carbon dioxide—never use a direct water stream on burning dust clouds
Unsuitable Media: High-velocity water could spread fine dust particles, increasing risk
Special Hazards: Combustion releases carbon oxides, nitrogen oxides, sulfur oxides, and methyl mercaptan fumes
Protective Equipment: Firefighters should use self-contained breathing apparatus and protective clothing, especially in poorly ventilated spaces or large warehouse settings
Fire and Explosion Hazards: Accumulated powder forms explosive mixtures with air under certain conditions, highlighting the need for dust control and grounding procedures
Personal Precautions: Long sleeves, goggles, gloves, and dust respirator prevent direct contact and inhalation during clean-up
Spill Cleanup Methods: Sweep up gently, minimizing dust clouds, and collect in a labeled, closed container; use HEPA filter-equipped vacuums if available; avoid dry sweeping in occupied areas
Environmental Precautions: Prevent entry into sewers or local waterways by sealing off drains and using spill containment tools
Reporting Requirements: Not typically subject to mandatory release reporting unless combined with significant water contamination or chemical mixing
Handling: Avoid creating or breathing dust; keep away from open flames and static discharge sources; grounding systems for storage bins and transfer systems reduce dust explosion threat
Hygiene Measures: Wash hands after handling; remove contaminated clothing before meals or breaks
Storage Conditions: Store in sealed containers, cool and dry location, protected from sunlight and strong oxidizers; monitor warehouse humidity to prevent caking or product degradation
Incompatible Materials: Acidic or oxidizing agents—such as perchlorates, nitrates, or chlorine—accelerate decomposition or trigger unsafe reactions
Engineering Controls: Local exhaust ventilation and dust extraction equipment reduce airborne concentrations in production, transfer, and packaging areas
Occupational Exposure Limits: Not established for L-methionine, but standard nuisance dust limits apply (e.g., OSHA PEL 15 mg/m³ total dust)
Respiratory Protection: NIOSH-approved dust mask or respirator required for dusty work
Eye/Face Protection: Chemical splash goggles for bulk handling
Skin Protection: Gloves and standard lab coats or coveralls; for long-term exposure, chemical-resistant gloves
General Hygiene: Provide eye wash and shower facilities near work zones; proper staff training prevents accidents caused by complacency or rushed procedures
Appearance: White to off-white crystalline powder
Odor: Faint sulfur smell (like boiled eggs)
Molecular Weight: 149.21 g/mol
Melting Point: 281°C (dec)
Boiling Point: >200°C
Solubility: Soluble in water, insoluble in organic solvents like ether
pH (1% solution): 5.5–6.1
Vapor Pressure: Not volatile
Density: 1.34–1.41 g/cm³ at 20°C
Partition Coefficient: log Kow = -2.6; product does not bioaccumulate
Chemical Stability: Stable under normal conditions; no unusual degradation if protected from moisture and heat
Hazardous Reactions: Strong acids, oxidizers, and bases accelerate unwanted reactions or degradation; avoid mixing with products like nitrates or hypochlorites
Decomposition Products: Sulfur oxides, methyl mercaptan and ammonia gas release in strongly heated or burned material
Polymerization: Will not occur under recommended use and storage
Acute Toxicity: LD50 (oral, rat) approximately 5,600 mg/kg or higher, which ranks the compound as low toxicity by common regulatory standards
Irritation: Mild eye/skin irritation possible with high or repeated exposure, but not sensitizing in animal studies or documented human cases
Chronic Exposure: Prolonged handling in high dust environments may trigger mild respiratory symptoms, improved by engineering controls and personal protection
Carcinogenicity: Not listed by IARC, ACGIH, NTP, or OSHA as carcinogenic
Target Organs: No confirmed target organ damage in humans or established animal studies at occupational exposure levels
Acute Aquatic Toxicity: LC50 (fish, 96h) > 100 mg/L; not acutely toxic to aquatic life
Persistence and Degradability: Readily biodegradable in soil and water via standard environmental pathways
Bioaccumulation Potential: Very low; log Kow values confirm low hazard for trophic transfer
Soil Mobility: Dissolves and disperses quickly if wetted, does not bind strongly to soil particles
Other Adverse Effects: Not known to affect wastewater operations or biota at environmental levels expected from accidental spills or disposal
Waste Treatment Methods: Dispose through licensed chemical waste contractor, landfilling or incineration as dictated by local authority
Product Disposal: Avoid large releases to environment, follow recommended procedures for “non-hazardous” organic waste in most districts
Container Disposal: Triple rinse containers before discarding as plastic or metal scrap; label as chemical residue until fully cleaned
Regulatory Compliance: Disposal practices shaped by region—always follow local, regional, and national requirements to limit environmental impact
UN Number: Not regulated by ADR/RID/IMDG/ICAO as a hazardous material
Proper Shipping Name: Methionine, not hazardous
Transport Class: General cargo; dust control and moisture-sensitive packaging keep product stable
Packing Group: Not assigned—product does not meet any hazardous transport criteria
Special Precautions: Use sealed packaging in bulk transport; avoid stacking heavy loads upon product bags to prevent leaking or caking in transit
Safety Assessment: Verified safe for use in food and feed at permitted levels by EU (EFSA), US (FDA/AAFCO), and other major markets
GHS Status: Not classified as hazardous for health or environment
US TSCA Inventory: Listed
EU REACH Registration: Registered, no special restrictions
Other Labeling Requirements: SDS, workplace safety posters, and worker safety briefings ensure that knowledge about proper handling and potential risks reaches all handlers
Occupational Protection Laws: Covered by general dust and chemical product regulations; falls under OSHA’s right to know and chemical hygiene standards in labs and industry
