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Material Safety Data Sheet (MSDS): L-Lysine

Identification

Product Name: L-Lysine
Synonyms: 2,6-Diaminohexanoic acid, L-2,6-Diaminohexanoic acid, Lysine
Chemical Formula: C6H14N2O2
Molecular Weight: 146.19 g/mol
CAS Number: 56-87-1
Recommended Use: Nutritional supplement, feed additive, pharmaceutical intermediate
Supplier Details: Manufacturer’s full name, address, emergency contact number, email
Emergency Phone: 24-hour emergency contact for immediate assistance
Relevant Identifiers: EINECS No. 200-294-2, UN No. Not classified

Hazard Identification

GHS Classification: Not classified as hazardous according to regulation (EC) No 1272/2008
Signal Word: None
Hazard Statements: Product presents little hazard to human health or the environment, may cause mild irritation to eyes and skin
Pictogram: None
Precautionary Statements: Avoid contact with eyes, skin, and clothing; prevent inhalation of dust
Potential Health Effects: Eyes: May cause irritation, Skin: May cause mild irritation, Ingestion: No significant effects under normal use, Inhalation: May cause respiratory irritation if dust present

Composition / Information on Ingredients

Chemical Name: L-Lysine (monohydrochloride may also be present in commercial forms)
Concentration: ≥98% pure
Impurities: Trace water, minor organic or inorganic residues (typically <1%)
Ingredient EINECS: 200-294-2
CAS Number: 56-87-1
Other Names: Essential amino acid derivative, pharmaceutical grade amino acid supplement

First Aid Measures

Inhalation: Move affected individual to fresh air immediately, allow rest, seek medical attention if irritation or difficulty breathing persists
Skin Contact: Remove contaminated clothing, wash area with soap and water, seek medical aid if irritation continues
Eye Contact: Rinse carefully with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, consult medical advice later if discomfort persists
Ingestion: Rinse mouth thoroughly, drink water if conscious, seek advice if discomfort or reactions occur
Notes for Physicians: Symptomatic and supportive treatment, no known specific antidote

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, CO2, foam
Unsuitable Extinguishing Media: Strong water jets may disperse product
Specific Hazards: Combustible but not highly flammable, thermal decomposition may release nitrogen oxides, carbon oxides
Protective Equipment: Full protective gear including self-contained breathing apparatus, gloves, safety goggles when handling fires involving powders
Special Procedures: Avoid inhalation of smoke, use fire-fighting measures appropriate to conditions

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel, wear suitable protective clothing, gloves, safety goggles, avoid direct contact
Environmental Precautions: Prevent entry into drains, surface water, or soil
Clean-up Methods: Collect spills mechanically, sweep or vacuum up powder, avoid generating dust, place in appropriate waste containers for disposal following local rules
Disposal: Dispose of according to section on Disposal Considerations

Handling and Storage

Handling: Handle in well-ventilated area, use proper industrial hygiene, avoid creating dust, wash hands after handling, do not eat, drink, or smoke during processing
Storage Conditions: Store in tightly sealed containers, keep in dry, cool, and well-ventilated space, protect from moisture and incompatible materials
Incompatibilities: Strong oxidizers, strong acids or bases may cause degradation
Storage Temperature: Maintain between 5–25°C for best performance
Shelf Life: Usually stable for at least 2 years under recommended storage

Exposure Controls and Personal Protection

Exposure Limits: Not established for L-Lysine, general dust nuisance level: 10 mg/m³ for inhalable particles, 3 mg/m³ respirable
Engineering Controls: Local exhaust ventilation, minimize dust release with suitable equipment
Personal Protection: Respiratory protection for dust producing operations (e.g., NIOSH-approved mask), safety goggles, lab coat or dedicated work clothing, protective gloves (nitrile or latex)
Hygiene Measures: Thorough washing before breaks and after handling, keep work areas clean and clear of waste

Physical and Chemical Properties

Appearance: White or slightly off-white powder or crystals
Odor: Odorless or slight characteristic smell
pH in Solution: Roughly 5–7 (2.5% solution in water)
Melting Point: 215–224°C (with decomposition)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Highly soluble in water, very slightly soluble in organic solvents
Vapor Pressure: Negligible at standard conditions
Density: ~1.28 g/cm³
Other Properties: Non-volatile, hygroscopic under high humidity

Stability and Reactivity

Chemical Stability: Stable under recommended conditions, sensitive to excessive heat, acidic or basic environments
Conditions to Avoid: Moisture, high temperatures, contact with oxidizers
Incompatible Materials: Strong oxidizing agents, mineral acids, alkalis
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, ammonia under fire conditions
Polymerization: Will not occur

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >5,000 mg/kg, practically non-toxic by ingestion
Skin Irritation: Not expected to cause significant irritation under normal conditions
Eye Irritation: May cause mild mechanical irritation
Inhalation: Dust may cause mild respiratory discomfort
Chronic Effects: Not known to cause chronic harm, no evidence of carcinogenic, mutagenic, or reproductive toxicity in scientific literature
Medical Conditions Aggravated by Exposure: Pre-existing respiratory conditions could be irritated by exposure to dust

Ecological Information

Eco-toxicity: Not considered dangerous to aquatic life or soil organisms at typical environmental concentrations
Mobility: High solubility in water, potential to move into groundwater if released in large quantities
Persistence and Degradability: Readily biodegradable, breaks down into natural products in soil and water
Bioaccumulation Potential: Does not accumulate in organisms
Other Effects: Over-enrichment of water can contribute to algal blooms in rare cases with massive discharges

Disposal Considerations

Product Disposal: Small quantities may be disposed as regular waste in accordance with local, state, and national regulations; for larger amounts, incineration or landfill in licensed facility as non-hazardous waste
Contaminated Packaging: Triple rinse containers, dispose following official requirements
Sewage Disposal: Discourage disposal to wastewater due to nutrient enrichment risk
Special Instructions: Consult local regulatory authorities for large-scale disposal

Transport Information

UN Number: Not regulated
Proper Shipping Name: Not subject to ADR, IMDG, or IATA regulations
Class: Not restricted
Packing Group: Not assigned
Labeling Requirements: None
Special Precautions: Avoid moisture ingress, pack in secure, sealed containers for transport

Regulatory Information

Regulatory Status: Not considered a hazardous substance or mixture within the meaning of OSHA Hazard Communication Standard (US), WHMIS (Canada), REACH/CLP (EU)
Inventory Status: Listed on TSCA (US), EINECS (EU), DSL (Canada), AICS (Australia), ENCS (Japan), KECI (Korea), PICCS (Philippines), and NZIoC (New Zealand)
Labelling: Not regulated, no specific hazard pictograms required under GHS
Other Regulations: Food additive and supplement regulations apply in some regions; check national legislation for food or feed applications