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Material Safety Data Sheet (MSDS) for L-(-)-Dibenzoyltartaric Acid Anhydrate

1. Identification

Product Name: L-(-)-Dibenzoyltartaric Acid Anhydrate
Chemical Formula: C18H14O8
Synonyms: L-(−)-Dibenzoyl-D-tartaric acid, (2R,3R)-(+)-Dibenzoyltartaric acid
CAS Number: 2743-38-6
Recommended Use: Chiral resolution, reagent in analytical chemistry, pharmaceutical intermediate
Manufacturer: Refer to supplier
Emergency Contact: Refer to local guidelines or supplier data sheet
Address: Based on supplier
Telephone Number: Refer to product packaging or local safety office

2. Hazard Identification

Classification: Irritant, harmful if swallowed, skin sensitizer
Signal Word: Warning
GHS Symbols: Exclamation mark
Hazard Statements: Causes moderate eye and skin irritation; may cause allergic skin reaction; harmful if swallowed
Precautionary Statements: Avoid breathing dust; wash hands after handling; do not eat, drink, or smoke when using
Potential Risks: Eye, skin, and respiratory tract irritation, allergic response on repeated exposure, possible environmental hazards in aquatic settings
Route of Exposure: Inhalation, skin and eye contact, ingestion
Target Organs: Eyes, skin, mucous membranes

3. Composition / Information on Ingredients

Chemical Name: L-(-)-Dibenzoyltartaric Acid Anhydrate
Concentration: 98–100% purity
Impurities: Residual solvents, trace related tartaric derivatives (typically <2%)
EC Number: 220-369-7
Molecular Weight: 358.30 g/mol
Other Names: Dibenzoyl-L-tartaric acid

4. First Aid Measures

Inhalation: Move person to fresh air; seek medical attention for breathing difficulty
Skin Contact: Wash skin with soap and plenty of water; remove contaminated clothing; seek care for irritation
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes; hold eyelids apart; seek medical help if irritation persists
Ingestion: Rinse mouth with water; never give anything by mouth to unconscious person; call physician or poison center
Most Important Symptoms: Irritation, redness, burning sensation, nausea if ingested
Special Instructions: Show this data sheet to the medical responder; use safety protocols in all cases

5. Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, water spray
Unsuitable Media: High-pressure water streams
Specific Hazards: On combustion, may release carbon oxides, benzoic acid fumes
Protective Gear: Full-face self-contained breathing apparatus, chemical resistant suit
Special Procedures: Remove sources of ignition, contain contaminated runoff; cool fire-exposed containers
Flammability: Non-flammable solid, decomposition under extreme heat

6. Accidental Release Measures

Personal Precautions: Use gloves, safety goggles, dust mask; evacuate unnecessary personnel
Environmental Precautions: Prevent product from entering drains, surface water, or soil
Containment Methods: Collect spillage with inert material (sand, vermiculite); place in chemical waste container
Clean-Up Procedure: Sweep up avoiding dust formation; ventilate area; wash affected surfaces with detergent
Disposal of Waste: Follow local, regional, national regulations for hazardous chemical disposal

7. Handling and Storage

Handling: Handle in chemical fume hood; wear personal protective gear; avoid dust generation; do not ingest or inhale
Storage Conditions: Store in tightly sealed, labeled containers; keep in cool, dry, well-ventilated area; protect from moisture and incompatible substances
Storage Incompatibilities: Strong bases, oxidizers, reducing agents
Specific Requirements: Use secondary containment, segregate from food and feedstuffs

8. Exposure Controls and Personal Protection

Occupational Exposure Limits: No established TLV or PEL; minimize exposure by engineering controls
Engineering Controls: Chemical fume hood, local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, lab coat, respiratory mask for dust
Hygiene Measures: Wash hands before breaks, after handling, and at the end of shift
Environmental Controls: Contain spills, use closed systems if available

9. Physical and Chemical Properties

Appearance: Off-white to light yellow crystalline powder
Odor: Slight aromatic, faint
Melting Point: Approx. 154–157°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in ethanol, methanol, acetone
Density: About 1.54 g/cm³
pH: Not available
Vapor Pressure: Not applicable
Flash Point: Not available
Partition Coefficient (n-octanol/water): Not determined
Autoignition Temperature: Not established
Viscosity: Not applicable (solid)

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage
Conditions to Avoid: Excess heat, moisture, open flames, incompatible chemicals
Materials to Avoid: Strong oxidizing agents, strong bases, acids, reducing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, benzaldehyde, benzoic acid
Polymerization: No hazardous polymerization expected under normal handling

11. Toxicological Information

Acute Toxicity: Data limited; estimated oral LD50 (rat) likely >2000 mg/kg
Skin Corrosion/Irritation: May cause mild skin irritation; prolonged contact can increase severity
Eye Damage/Irritation: Moderate irritant possible
Respiratory Sensitization: Dust may provoke irritation in sensitive individuals
Skin Sensitization: Possible allergenic reaction in predisposed users
Long-term Effects: No confirmed chronic toxicity; may aggravate pre-existing conditions of skin or respiratory tract
Carcinogenicity/Mutagenicity: No known data
Reproductive Toxicity: No studies available
Other Information: Use care during all handling to avoid unnecessary exposure

12. Ecological Information

Ecotoxicity: Not acutely toxic to aquatic life at typical concentrations, but excessive release may disrupt aquatic environments
Persistence/Degradability: Compound is not persistent; biodegradable by microbial action over an extended period
Bioaccumulative Potential: Not likely to bioaccumulate due to low water solubility and molecular size
Mobility in Soil: Low; limited water solubility decreases mobility
Other Ecological Effects: Keep out of watercourses to avoid localized harm, even at low levels

13. Disposal Considerations

Waste Treatment Methods: Utilize hazardous waste handler registered with local authorities
Contaminated Packaging: Triple rinse containers, dispose as hazardous waste
Disposal Regulations: Follows regional, national, international guidelines for chemical waste
Special Instructions: Do not release to environment or drains; incinerate at high temperature if possible
Other Disposal Notes: Consult licensed waste disposal service to ensure compliance

14. Transport Information

UN Number: Not classified as hazardous dangerous goods under international transport regulations
UN Proper Shipping Name: L-(-)-Dibenzoyltartaric Acid, not regulated
Transport Hazard Class: Non-hazardous
Packing Group: Not applicable
Environmental Hazards: None assigned
Special Precautions: Keep containers upright, dry, and closed; ensure secondary containment for bulk transport
Transport Label: None required
Additional Info: Follow shipping guidelines for chemicals; vehicle operators should know product hazards

15. Regulatory Information

US TSCA: Listed on Toxic Substances Control Act Inventory
Europe EINECS: Listed as EC Number 220-369-7
Canada DSL/NDSL: Listed
REACH Status: Registered or exempt for research and development purposes
Hazard Symbols: GHS07 (Exclamation Mark)
Risk Phrases: R22 (Harmful if swallowed), R36/37/38 (Irritating to eyes, respiratory system, and skin)
Safety Phrases: S24/25 (Avoid contact with skin and eyes)
WHMIS Classification (Canada): D2B (Toxic material causing other toxicity)
Other Regulatory Data: Follow all workplace substance control laws and report incidents to the appropriate local authority as needed