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Product Name: Kitasamycin
Chemical Family: Macrolide antibiotic
Synonyms: Leucomycin, Leucomycin A3
CAS Number: 5691-64-1
Recommended Uses: Veterinary medicine, antibacterial agent
Supplier Details: Supplier name, address, phone number, emergency contact
Classification: Eye irritation (Category 2A), respiratory sensitizer (Category 1), skin sensitizer (Category 1), specific target organ toxicity (single exposure, Category 3)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, may cause allergic skin reaction, suspected of damaging fertility or the unborn child
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Avoid breathing dust or fume, wash thoroughly after handling, wear protective gloves, use in well-ventilated area
Chemical: Kitasamycin
Concentration: Usually >95% (technical grade)
CAS Number: 5691-64-1
Other Components: Some formulations may contain excipients, stabilizers, or diluents such as starch or lactose (check label for specifics)
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and get medical attention if irritation persists.
Skin Contact: Remove contaminated clothing. Wash exposed skin with soap and water. Seek medical advice if rash or discomfort appears.
Inhalation: Move affected person to fresh air immediately. Support breathing as necessary. Seek prompt medical attention if breathing troubles occur.
Ingestion: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Call poison control or a physician for guidance.
Suitable Extinguishing Media: Dry chemical, CO2, water spray, foam
Unsuitable Media: Avoid high-pressure water streams
Hazardous Combustion Products: Emits toxic fumes under fire conditions including carbon monoxide, carbon dioxide, nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Specific Hazards: Dust may form explosive mixture in air. Heat may produce hazardous decomposition products.
Personal Precautions: Avoid inhalation of dust. Use respiratory protection and gloves.
Environmental Precautions: Prevent runoff to soil, sewers, surface water, and groundwater.
Spill Cleanup Methods: Sweep up and place material in suitable containers for disposal. Clean spill site thoroughly with detergent and water. Avoid creating dust. Ventilate area.
Handling: Avoid breathing dust or vapors. Handle in well-ventilated places. Wear protective equipment such as gloves, goggles, and masks. Wash hands after use.
Storage Conditions: Keep containers tightly closed in a cool, dry location. Store away from incompatible materials such as acids, oxidizers, and strong bases. Protect from moisture, light, and excessive heat. Clearly label storage containers.
Exposure Limits: No established OSHA PEL or ACGIH TLV for Kitasamycin. Limit exposure as low as reasonably achievable.
Engineering Controls: Use with local exhaust ventilation or in a chemical fume hood.
Personal Protective Equipment (PPE): Safety glasses or chemical goggles, laboratory coat or equivalent protective clothing, suitable gloves (e.g. nitrile), and approved respirator if exposure limits may be exceeded.
Hygiene Measures: Wash thoroughly after handling, avoid eating or drinking in the work area, change out of contaminated clothing promptly.
Appearance: White to light yellow crystalline powder
Odor: Faint characteristic odor
Molecular Formula: C35H59NO13
Molecular Weight: 701.85 g/mol
Melting Point: 124–128°C
Solubility: Soluble in methanol, ethanol, and chloroform; slightly soluble in water
pH: No data available for pure powder; solutions are typically weakly acidic
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible at room temperature
Density: 1.2–1.3 g/cm³ (approximate)
Chemical Stability: Stable under recommended storage conditions and at room temperature.
Reactivity: Avoid strong acids, strong bases, and oxidizing agents.
Conditions to Avoid: Moisture, excessive heat, light exposure.
Decomposition Products: Thermal decomposition emits irritating fumes and gases including carbon oxides and nitrogen compounds.
Hazardous Polymerization: Will not occur under normal conditions.
Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg; typically low acute toxicity.
Routes of Exposure: Inhalation, ingestion, skin and eye contact.
Chronic Toxicity: Long-term or repeated exposure may cause allergic reactions, respiratory or skin sensitization.
Symptoms: Eye and skin irritation, allergic responses, respiratory discomfort.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA.
Mutagenicity and Reproductive Effects: Not enough evidence to confirm mutagenic or reproductive effects in humans, though some studies highlight concerns in animal models.
Target Organs: Eyes, skin, respiratory system.
Ecotoxicity: Toxic to aquatic organisms and may cause long-term adverse effects in the aquatic environment.
Mobility: May migrate in soil and contaminate water sources.
Persistence and Degradability: Moderately persistent; degraded by photolysis and some bacteria though breakdown in environment takes time.
Bioaccumulative Potential: Low to moderate potential.
Other Effects: Avoid unnecessary release to the environment. Waste management routes should minimize aquatic exposure.
Waste Disposal Methods: Dispose through licensed chemical waste contractor. Do not dispose to drains, surfaces, or the environment.
Contaminated Packaging: Containers should be thoroughly emptied and then rinsed, disposed of in line with local, state, and federal regulations.
Special Precautions: Prevent release into the environment during disposal. Incineration preferred for bulk material under permitted facilities.
UN Number: Not classified as a dangerous good for transport by current ADR, IMDG, IATA standards.
Transport Hazard Class: None assigned
Packing Group: Not regulated
Environmental Hazards: Avoid accidental release during packing or transit
Transport Labels: Not required
Special Transport Precautions: Store in original, tightly closed packaging. Protect from weather; avoid rough handling.
US Regulations: Not listed as a hazardous substance under CERCLA, SARA 302, SARA 313. May be regulated under TSCA for research and development.
EU Regulations: Not classified as a dangerous substance under Regulation (EC) No 1272/2008 (CLP/GHS). Provided with safety phrases regarding handling and exposure.
Other Regulations: Handle according to local, regional, national, and international regulations. Product use limited to intended applications specified by relevant industry and governmental authorities.
Workplace Safety: Suitable risk assessments, training, and controls should be in place for users handling antibiotics like Kitasamycin.
