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Product Name: Ixazomib Citrate
Chemical Name: 2S-2-[(2-methyl-1-oxopropyl)amino]-4-phenyl-1,3-thiazole-5-carboxamide, citrate (1:1)
Synonyms: MLN9708, Ninlaro
CAS Number: 1239908-20-9 (Ixazomib), 6138-13-8 (Citrate)
Manufacturer: Pharmaceutical manufacturer or supplier
Recommended Uses: Investigational drug, research and pharmaceutical use
Contact Information: Emergency phone number for manufacturer or supplier
GHS Classification: Acute toxicity – Oral (Category 2), Specific target organ toxicity (STOT) repeated exposure (Category 2), Reproductive toxicity (Category 2), Eye irritation (Category 2)
Signal Word: Danger
Hazard Statements: Toxic if swallowed. May cause eye irritation. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: Avoid breathing dust, wear suitable PPE, wash hands thoroughly after handling, do not eat or drink when using.
Potential Health Effects: Exposure may cause systemic toxicity, irritation to eyes and respiratory tract, adverse effects on reproductive system.
Chemical Name: Ixazomib Citrate
Common Name: Ixazomib Citrate
CAS Number: 1239908-20-9 (Ixazomib); 6138-13-8 (Citrate)
Concentration: 100% (pure substance)
Impurities: Trace process-related impurities may be present, specific information available from supplier.
Inhalation: Move affected person to fresh air. Seek medical attention if symptoms such as coughing, respiratory distress or irritation occur.
Skin Contact: Wash skin immediately with soap and water. Remove contaminated clothing and seek medical attention for persistent irritation.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present. Seek medical attention if irritation persists.
Ingestion: Seek immediate medical advice. Rinse mouth with water; do not induce vomiting unless advised by medical personnel.
Most Important Symptoms/effects: Nausea, headache, dizziness, eye and respiratory irritation, potential systemic effects on prolonged exposure.
Note to Physician: Symptomatic treatment and monitoring recommended. Potential delayed toxicity possible.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam. Choose extinguishing media suitable for surrounding materials.
Specific Hazards Arising from Substance: Combustion can produce carbon oxides, nitrogen oxides, sulfur oxides, potentially irritating or toxic fumes.
Advice for Firefighters: Wear self-contained breathing apparatus and full protective gear. Avoid inhalation of combustion products.
Additional Information: Prevent runoff from entering drains or water sources. Cool exposed containers with water spray.
Personal Precautions: Use personal protective equipment including gloves, laboratory coat, eye protection, and suitable respiratory protection as necessary.
Environmental Precautions: Prevent material from entering waterways, drains, and soil. Notify relevant environmental authorities if contamination occurs.
Methods for Containment and Cleaning Up: Sweep up gently using non-sparking tools. Scoop spilled material into a suitable container for disposal. Wipe area with a damp cloth or absorbent material. Clean and ventilate the area thoroughly.
Reference to Other Sections: Refer to sections on personal protection and disposal considerations.
Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation of dust. Use in a controlled environment like a fume hood. Wash hands after handling and before eating, drinking, or smoking.
Conditions for Safe Storage: Store in a tightly closed container, in a cool, dry, well-ventilated area. Protect from light, heat, and moisture. Keep away from incompatible materials such as oxidizing agents.
Specific End Uses: For pharmaceutical or research use; not for food, cosmetic or household use.
Exposure Limits: No specific occupational exposure limit assigned. Handle using pharmaceutical industry best practices for potent compounds.
Engineering Controls: Work under chemical fume hood or local exhaust system. Use closed systems where feasible.
Respiratory Protection: Suitable respirator in case of insufficient ventilation or when handling bulk powder.
Eye Protection: Chemical safety goggles or face shield.
Skin Protection: Chemical-resistant gloves, laboratory coat, and suitable protective clothing.
Hygiene Measures: Wash hands and any exposed skin before breaks and after work. Remove contaminated clothing and PPE after use.
Appearance: White to off-white solid
Odor: Odorless or faint
Odor Threshold: Information not available
pH: Information not available
Melting Point/Freezing Point: Information not available
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Information not available
Evaporation Rate: Not determined
Flammability: Not classified as highly flammable
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: Not available
Solubility: Slightly soluble in water, more soluble in DMSO or methanol
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Information not available
Decomposition Temperature: Information not available
Reactivity: Stable under recommended handling and storage conditions
Chemical Stability: Stable in original packaging under normal temperature and dry conditions
Possibility of Hazardous Reactions: Will not polymerize under normal conditions
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides on combustion
Acute Toxicity: Toxic by oral exposure, data from animal studies indicate significant effects at low doses
Skin Corrosion/Irritation: May cause skin irritation
Serious Eye Damage/Irritation: May cause eye irritation
Respiratory or Skin Sensitization: Not classified, but dust or powder may irritate respiratory tract
Germ Cell Mutagenicity: Not classified as mutagenic based on available data
Carcinogenicity: No classification as carcinogenic, long-term effects not thoroughly studied in humans
Reproductive Toxicity: Suspected reproductive toxin based on animal studies
STOT-single exposure: May cause acute toxicity affecting organs
STOT-repeated exposure: Prolonged exposure may impact liver, kidneys, blood
Aspiration Hazard: No data available
Additional Information: Clinical effects may include gastrointestinal disturbance, hematologic changes, neuropathy.
Ecotoxicity: May be harmful to aquatic life with long lasting effects, toxicity data is limited
Persistence and Degradability: Persistence expected based on structure, biodegradability not established
Bioaccumulative Potential: Data not sufficient, potential for bioconcentration cannot be ruled out
Mobility in Soil: Not characterized, likely low mobility
Other Adverse Effects: Released material may be hazardous to the environment, especially aquatic ecosystems
Waste Treatment Methods: Dispose of unused substance and contaminated materials as hazardous waste in accordance with local, regional, national regulations.
Contaminated Packaging: Properly rinse empty containers and dispose of in an approved facility.
Other Information: Do not release to sewer or waterways; incinerate in a licensed facility if possible. Coordinate with qualified disposal companies.
UN Number: Not classified as a hazardous material under most transport regulations (provide specifics if required by regulations)
Proper Shipping Name: Not regulated
Transport Hazard Class(es): None assigned
Packing Group: None assigned
Special Precautions for Transport: Minimize vibration and physical damage during shipment, secure packaging
Environmental Hazards: Avoid release of large quantities into the environment
Safety, Health, and Environmental Regulations: Subject to chemical safety and occupational health laws, consult regulations for handling pharmaceutical products
Global Inventory Listing: Not all components listed on TSCA, DSL, or similar chemical inventories
Other Regulatory Information: Handled as a prescription drug in many countries, specific workplace exposure controls apply in pharmaceutical settings
Labeling Requirements: Follow all relevant labeling provisions for laboratory and pharmaceutical handling
Workplace Classification: Handle in compliance with local, state, and federal safety regulations regarding potent, hazardous chemicals used in medical settings
