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Material Safety Data Sheet: Isopropyl β-D-Thiogalactopyranoside (IPTG)

1. Identification

Product Name: Isopropyl β-D-Thiogalactopyranoside
Synonyms: IPTG; 1-Isopropyl-β-D-thiogalactopyranoside
Chemical Formula: C9H18O5S
CAS Number: 367-93-1
Intended Use: Laboratory reagent, not recommended for drug, household, food, or cosmetic use
Supplier: Laboratory chemical suppliers, research organizations
Contact Information: Supplier emergency phone number or safety resource contact

2. Hazard Identification

Classification: Not classified as hazardous under GHS
Routes of Exposure: Skin contact, inhalation, ingestion, eye contact
Potential Health Effects: May cause mild irritation to skin, eyes, respiratory tract, or if swallowed; not identified as a carcinogen, reproductive toxin, or mutagen
Signal Word: None
Hazard Statements: May cause minor irritation to membranes and exposed tissues
Precautionary Statements: Avoid breathing dust, ensure good ventilation, prevent direct skin and eye contact, wash hands thoroughly after handling
Pictograms: Not a GHS-labeled hazard

3. Composition / Information on Ingredients

Chemical Name: Isopropyl β-D-thiogalactopyranoside
Synonyms: IPTG, Isopropylthiogalactoside
CAS Number: 367-93-1
Concentration: >99% pure
Other Components: Trace impurities from manufacturing process below reporting thresholds
Molecular Weight: 238.31 g/mol

4. First Aid Measures

General Advice: Seek fresh air, help individual move calmly from exposure, pursue medical attention as symptoms arise
Inhalation: Remove individual to fresh air immediately, comfort and observe, seek medical help should symptoms persist
Skin Contact: Wash area thoroughly with plenty of soap and water, remove contaminated clothing, obtain medical care if rash or discomfort continues
Eye Contact: Rinse eyes with gentle steady stream of water for at least 15 minutes, lift eyelids periodically, consult a physician if irritation stays
Ingestion: Rinse mouth, do not induce vomiting, provide water to dilute, obtain medical attention
Note to Physicians: No specific antidote; treat symptomatically based on exposure

5. Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical, water spray, regular foam
Specific Hazards: May emit carbon oxides and sulfur oxides if burned
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Special Procedures: Apply water spray to cool exposed containers, withdraw personnel not involved in firefighting, prevent runoff from entering sewers or water sources
Combustion Products: Carbon dioxide, carbon monoxide, sulfur oxides

6. Accidental Release Measures

Personal Precautions: Prevent skin and eye contact, avoid dust formation, ventilate area thoroughly, use proper protective equipment
Environmental Precautions: Prevent further leakage or spillage if safe, avoid entry into waterways, soil, or drains
Cleanup Methods: Sweep up material carefully, place in labeled waste container, clean surface with water, avoid generating airborne dust, dispose of according to local regulations
Decontamination: Wash spill site with water and appropriate cleaning agent after material pickup

7. Handling and Storage

Handling: Minimize dust generation, use in well-ventilated setting, keep containers tightly sealed, wear appropriate personal protective equipment, avoid inhaling powder, avoid consumption of food or drink during use, practice standard laboratory hygiene
Storage: Store in cool, dry space away from incompatible substances, keep container closed, shield from moisture and heat sources, label containers clearly, reserve area for chemical storage, restrict access to trained personnel

8. Exposure Controls and Personal Protection

Engineering Controls: Use fume hood or localized exhaust, maintain good ventilation at work stations
Exposure Limits: No established occupational exposure limits for IPTG, general dust limits apply
Personal Protective Equipment: Nitrile or latex gloves, chemical splash goggles, laboratory coat or apron, respiratory protection if dust is generated or limits could be exceeded
Hygiene Measures: Wash hands thoroughly after handling, avoid touching face, eyes, or skin with contaminated gloves, remove and clean protective gear before leaving the workspace

9. Physical and Chemical Properties

Appearance: White crystalline powder
Odor: Odorless or slight sulfurous scent
pH: Not available
Melting Point: 108-111°C
Boiling Point: Not applicable (decomposes prior to boiling)
Solubility: Soluble in water, insoluble in most organic solvents
Vapor Pressure: Not available
Density: Approximately 1.37 g/cm3
Partition Coefficient: Not available
Flash Point: Not applicable
Evaporation Rate: Not available

10. Stability and Reactivity

Chemical Stability: Stable under recommended conditions
Incompatible Materials: Strong oxidizing agents
Hazardous Decomposition: Carbon monoxide, carbon dioxide, sulfur oxides
Conditions to Avoid: High humidity, excessive heat, open flames, contact with incompatible materials
Polymerization: Will not occur

11. Toxicological Information

Acute Toxicity: Not expected to be acutely toxic at normally encountered laboratory levels; ingestion of large amounts may result in mild gastrointestinal discomfort
Skin Corrosion/Irritation: May cause mild irritation to skin from repeated or prolonged contact
Eye Damage/Irritation: May cause mild irritation, redness, discomfort
Respiratory: Inhalation of dust can cause mild irritation in airway passages
Sensitization: Not expected based on known usage
Carcinogenicity: Not listed by IARC, ACGIH, NTP, OSHA
Mutagenicity: Not reported as mutagenic in standard assays
Reproductive Toxicity: Not known to cause reproductive harm or developmental toxicity
Chronic Effects: Prolonged or repeated exposure may cause mild discomfort or irritation

12. Ecological Information

Ecotoxicity: No data suggesting significant hazardous effects to aquatic or terrestrial organisms
Persistence and Degradability: Expected to degrade gradually in biological or natural systems
Bioaccumulation: Unlikely to bioaccumulate significantly
Mobility in Soil: Dissolves readily in water, may migrate through soil with runoff
Other Adverse Effects: No major ecological impacts recognized for laboratory-scale releases

13. Disposal Considerations

Waste Treatment Methods: Collect and place in appropriately labeled, sealed container for hazardous waste disposal
Disposal of Products: Use licensed chemical waste contractor, follow local, state, or national environmental regulations
Disposal of Contaminated Packaging: Dispose of as unused chemical product, avoid recycling containers if contaminated
Avoid Release: Prevent uncontrolled release of material to the environment or sewers

14. Transport Information

UN Number: Not classified as a dangerous good for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant
Special Precautions: Ship in original container, secondary containment for large volume, follow supplier advice for temperature control during shipments
Regulations: Follow standard provisions for non-hazardous laboratory chemicals

15. Regulatory Information

Inventory Listings: Registered in common country inventories like TSCA, DSL, EINECS
Safety, Health, and Environmental Regulations: Not subject to specific labeling requirements for hazardous substances
OSHA Hazards: Not categorized as hazardous
SARA Title III: Not considered a hazardous chemical under this regulation
California Proposition 65: No ingredients listed
Other Regulatory Data: Observe workplace safety laws and enforce risk management through use of standard personal protective equipment and proven lab protocols