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Name: Isopropyl Chloroformate
Chemical Formula: C4H7ClO2
Other Names: Carbonochloridic acid, 1-methylethyl ester; Chloroformic acid isopropyl ester
CAS Number: 35123-06-9
Hazard Class: Flammable, Toxic, Corrosive
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, toxic if inhaled, flammable liquid and vapor, may cause respiratory irritation, reacts violently with water generating toxic gas
Routes of Exposure: Inhalation, skin absorption, eye contact, ingestion
Target Organs: Eyes, skin, respiratory system, central nervous system
Substance: Isopropyl Chloroformate
Purity: Typically greater than 98%
Impurities: Traces of hydrochloric acid on decomposition
Inhalation: Move person to fresh air, keep comfortable, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin with copious running water for at least fifteen minutes, seek medical help
Eye Contact: Rinse cautiously with water for several minutes, remove contacts if easy to do, get immediate medical advice
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical assistance
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam
Unsuitable Media: Water jet may cause violent reaction with product
Special Hazards: Releases toxic gases such as phosgene, hydrogen chloride, and carbon monoxide upon combustion
Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus
Firefighting Instructions: Approach from upwind, contain runoff to prevent environmental contamination
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear chemical-resistant gloves and splash goggles
Spill Response: Use inert absorbent material, collect in compatible container for disposal
Environmental Precautions: Prevent entry into waterways, sewers, or soil
Decontamination: Wash spill site after removal
Handling: Perform all manipulations in a chemical fume hood, avoid breathing vapors, do not let chemical touch skin or eyes
Storage: Keep container tightly closed in a cool, dry, well-ventilated place away from incompatible substances, especially water, alcohols, acids, bases, and oxidizers
Incompatible Materials: Avoid moisture, strong acids, strong bases, and amines
Engineering Controls: Chemical fume hood, eye wash station, safety shower
Personal Protection: Chemical-resistant gloves, tightly sealed safety goggles, laboratory coat, suitable vapor respirator
Occupational Exposure Limits: No established US OSHA/NIOSH limit, but minimize exposure as much as possible due to severe toxicity
Hygiene Measures: Wash hands and face thoroughly after handling, remove contaminated clothing
Appearance: Colorless to pale yellow liquid
Odor: Sharp, pungent
Boiling Point: Around 90°C (194°F)
Melting Point: Not well documented
Flash Point: About 24°C (75°F)
Vapor Pressure: Moderate at room temperature
Solubility: Reacts with water, soluble in most organic solvents
Density: Roughly 1.08 g/cm³
Stability: Decomposes in water, sensitive to moisture
Chemical Stability: Unstable in presence of water or moisture
Hazardous Reactions: Reacts with water, alcohols, amines to form toxic and corrosive products
Decomposition Products: Hydrogen chloride, phosgene, isopropanol
Conditions to Avoid: Heat, sparks, flame, moisture, incompatible chemicals
Acute Effects: Severe irritation to respiratory tract, eyes, and skin; symptoms include coughing, shortness of breath, burns, blurred vision
Chronic Effects: Potential respiratory sensitization, prolonged skin exposure may cause dermatitis
Inhalation LC50 (rats): Not widely published, but expected to be low due to corrosivity and toxicity
Ingestion Effects: May be fatal, severe internal burns
Carcinogenicity: Not classified as carcinogen by IARC or OSHA, but risk assessment requires caution
Aquatic Toxicity: Harmful to aquatic organisms due to hydrolysis and release of toxic byproducts
Persistence and Degradability: Hydrolyzes rapidly in water, forming products with potential environmental impact
Mobility in Soil: Reacts quickly on release, little expected long-term mobility
Potential for Bioaccumulation: Low because of instability in environment
Disposal Methods: Incinerate in accordance with local regulations, or arrange disposal with a licensed hazardous waste facility
Precautions: Do not discharge into sewage or natural waterways, avoid evaporation into air
Empty Containers: Treat as hazardous due to residue, rinse with compatible solvent, dispose of solvent as hazardous waste
UN Number: 2735
Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (Isopropyl chloroformate)
Hazard Class: 8 (Corrosive), may be classified as 6.1 (Toxic) by some authorities
Packing Group: II or III depending on concentration and intended use
Labeling: Corrosive, Toxic, Flammable
Transport Precautions: Use appropriate containment, clearly mark containers, follow local and international regulations
Regulations: Covered under various chemical control laws such as REACH and US TSCA
Workplace Safety: OSHA laboratory safety standards apply, use of personal protective equipment mandatory in regulated workplaces
Environmental Release: Releases reportable under emergency planning and community right-to-know acts in several jurisdictions
