© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Isophorone Diisocyanate
Chemical Family: Aliphatic diisocyanate
Chemical Formula: C12H18N2O2
CAS Number: 4098-71-9
Synonyms: IPDI
Manufacturer Contact: Refer to supplier details on shipment label
Recommended Uses: Polyurethane polymers, coatings, adhesives, sealants
Emergency Phone Number: Refer to product label or local poison control
GHS Classification: Acute toxicity (inhalation, dermal), Skin corrosion/irritation, Serious eye damage/eye irritation, Respiratory sensitization, Skin sensitization, Specific target organ toxicity (single and repeated exposure)
Signal Word: Danger
Pictograms: Health hazard, acute toxicity, exclamation mark
Hazard Statements: Harmful if inhaled, causes skin and serious eye irritation, may cause allergy or asthma symptoms, may cause respiratory irritation or skin sensitization
Precautionary Statements: Avoid breathing mist/vapors, use only outdoors or in well-ventilated areas, wear protective gloves/eye/face protection, wash thoroughly after handling, store locked up away from incompatible materials
Substance: Isophorone Diisocyanate
CAS Number: 4098-71-9
Concentration: Typically >99% in pure form
Impurities: Trace amounts of isocyanate-related compounds possible
Additional Components: No significant additives or stabilizers present
Inhalation: Move to fresh air, seek immediate medical attention for breathing difficulty, keep person at rest
Skin Contact: Remove contaminated clothing, wash with plenty of water and soap, consult a doctor for persistent irritation or symptoms
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses if present, seek prompt medical attention if irritation persists
Ingestion: Do not induce vomiting, rinse mouth, call poison center or physician right away
Most Important Symptoms/Effects: Irritation, redness, allergic reactions, difficulty breathing, asthma-like symptoms
Notes for Emergency Responders: Use proper personal protective equipment; provide oxygen or artificial respiration if necessary
Suitable Extinguishing Media: Use water spray, dry powder, carbon dioxide, or foam
Unsuitable Media: Avoid direct water stream, may spread material
Special Hazards: Combustion produces toxic fumes including nitrogen oxides, carbon monoxide, hydrogen cyanide, and isocyanates
Protective Equipment: Wear full protective clothing and self-contained breathing apparatus
Firefighting Procedures: Remove containers from fire area if safe, cool containers with water mist, avoid inhaling fumes
Personal Precautions: Evacuate non-essential personnel, ventilate area, put on suitable protective clothing
Environmental Precautions: Prevent entry to drains, sewers, and waterways
Containment: Stop leak if safe, surround spill with non-combustible absorbent such as earth or sand
Cleanup Methods: Absorb with inert material, collect into labeled waste containers, decontaminate surface with a solution of ammonia and detergent
Disposal of Collected Material: Seal in chemical waste container, arrange proper disposal according to regulations
Precautions for Safe Handling: Keep containers tightly closed, avoid exposure to heat, moisture, and direct sunlight, use only with adequate ventilation, do not breathe fumes or vapor
Hygiene Measures: Wash hands before breaks and after handling, do not eat or drink in work area, prevent skin and eye contact
Storage Conditions: Store in cool, dry, well-ventilated area, away from incompatible substances like water, alcohols, amines, acids, and bases
Special Requirements: Ground all equipment, protect from moisture to reduce risk of formation of carbon dioxide gas and pressure buildup
Prohibited Practices: Do not re-use empty containers; residual vapors may pose risk
Exposure Limits: ACGIH TLV - 0.005 ppm (TWA); OSHA PEL - no specific limit for IPDI
Engineering Controls: Use local exhaust ventilation to keep levels below exposure limits, consider closed systems for manufacturing processes
Respiratory Protection: Wear full-face respirator with appropriate isocyanate filter when ventilation inadequate
Skin Protection: Use chemical-resistant gloves (e.g., nitrile, butyl rubber), wear protective clothing
Eye Protection: Use safety goggles and face shield
Additional Protection: Provide emergency showers and eyewash stations in work area
Appearance: Clear, colorless to pale yellow liquid
Odor: Sharp, pungent
Odor Threshold: Not determined
pH: Not applicable (reacts with water)
Melting Point/Freezing Point: -60°C
Boiling Point and Range: 158°C at 760 mmHg
Flash Point: 158°C (closed cup)
Evaporation Rate: Not determined
Flammability: Not highly flammable, but combustible
Upper/Lower Flammability or Explosive Limits: Not available
Vapor Pressure: 0.02 mmHg at 20°C
Vapor Density: 5.7 (air = 1)
Relative Density: 1.06–1.09 (water = 1)
Solubility: Reacts with water, soluble in most organic solvents
Partition Coefficient: Log Kow: estimated 3.13
Auto-ignition Temperature: 425°C
Decomposition Temperature: Not determined
Viscosity: Approx. 3–4.5 mPa·s at 25°C
Chemical Stability: Stable under recommended storage conditions; unstable with moisture
Possibility of Hazardous Reactions: Reacts violently with water, alcohols, acids, amines; forms CO2 gas, may cause pressure buildup
Conditions to Avoid: Contact with water and incompatible materials, heat, open flames
Incompatible Materials: Water, alcohols, amines, strong acids, alkalis, oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon dioxide, carbon monoxide, hydrogen cyanide, isocyanates
Acute Toxicity: LD50 (oral, rat): approx. 3,900 mg/kg; LD50 (dermal, rabbit): approx. 1,000 mg/kg; LC50 (inhalation, rat, 4h): approx. 0.09 mg/l
Skin Corrosion/Irritation: Can cause severe irritation or burns on prolonged contact
Serious Eye Damage/Irritation: Causes eye irritation, risk of severe, irreversible damage possible
Respiratory/Skin Sensitization: Exposure may lead to allergic asthma, bronchitis, or skin allergies; known to cause occupational asthma in some workers
Germ Cell Mutagenicity: Not expected based on available data
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: Data insufficient, no known direct risk
Specific Target Organ Toxicity (Single/Repeated): Respiratory tract
Effects of Overexposure: Coughing, wheezing, chest tightness, dermatitis, conjunctivitis, headache, nausea
Ecotoxicity: Toxic to aquatic organisms; LC50 (fish): 4.1 mg/L (96 h, Oryzias latipes); EC50 (daphnia): 89 mg/L (48 h)
Persistence and Degradability: Reacts with water, forms solid ureas that may persist in environment
Bioaccumulative Potential: Log Kow suggests moderate potential; actual bioaccumulation low due to rapid reactivity
Mobility in Soil: Low mobility; hydrolyzes on contact with moisture
Other Adverse Effects: Hydrolysis products may remain in sediments; pose risks to aquatic life
Disposal Recommendations: Treat as hazardous waste according to local, regional, and national regulations; do not dump into drains, groundwater or soil
Waste Treatment Methods: Do not dispose with household waste; incinerate or treat chemically with an appropriate neutralizing solution (such as dilute ammonia in water)
Contaminated Packaging: Dispose of empty containers as hazardous waste—even if well-drained
Special Precautions: Notify authorities if substantial release occurs; all personnel handling waste should wear full protective gear
UN Number: 2281
UN Proper Shipping Name: Isophorone Diisocyanate
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Yes, marine pollutant
Special Precautions: Avoid container shock during transport; comply with all labeling, documentation, and placarding requirements
Transport Labels: Toxic, environmentally hazardous substance
Transport by Air/Rail/Sea: Subject to regulations for dangerous goods; confirm specific carrier requirements
OSHA Status: Regulated as hazardous
TSCA Status: Listed on TSCA Inventory
SARA Title III: Section 302 (Extremely Hazardous): No, Section 313: Yes (reportable)
REACH Status: Registered
Other Regulations: Subject to local reporting requirements and workplace exposure monitoring
Labeling Requirements: Comply with OSHA, GHS, and regional labeling regulations
Workplace Controls: Annual worker training, exposure monitoring, health surveillance for respiratory sensitization
