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Product Name: Isobutyryl Chloride
Chemical Formula: C4H7ClO
Synonyms: 2-Methylpropanoyl chloride, Isobutanoyl chloride
CAS Number: 79-30-1
Recommended Use: Chemical intermediate for organic synthesis, pharmaceutical and agrochemical manufacturing
Supplier Address: Manufacturer or distributor details with up-to-date emergency phone number and physical address
Emergency Contact: Chemtrec or local poison control center
GHS Classification: Corrosive to skin, causes severe burns and eye damage; classified as hazardous under OSHA regulations
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; harmful if inhaled; may cause respiratory irritation
Precautionary Statements: Avoid breathing vapors; wash hands thoroughly after handling; wear protective gloves, eye, and face protection; use only outdoors or in a well-ventilated area
Pictograms: Corrosive, Exclamation Mark
Potential Health Effects: Severe irritation to eyes, skin, and respiratory system; may produce toxic gases upon contact with water or alcohols; inhalation of fumes can damage lungs
Environmental Hazards: Toxic to aquatic life; chemical runoff can pollute waterways
Substance: Isobutyryl Chloride
Concentration: 98-100%
Impurities: Trace amounts of hydrochloric acid and organic chlorides possible based on manufacturing source
Chemical Formula: C4H7ClO
Molecular Weight: 106.55 g/mol
Inhalation: Remove to fresh air immediately; see a physician if symptoms persist; administer oxygen if breathing is difficult
Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes; get medical attention
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing and seek immediate medical assistance
Ingestion: Do not induce vomiting; rinse mouth with water; seek immediate medical attention
Most Important Symptoms: Burning, redness, blistering, eye damage, respiratory distress
Special Notes: Immediate medical intervention required to prevent serious health effects
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or foam; water spray may be used to cool containers but avoid direct contact with liquid as hydrolysis releases corrosive HCl gas
Unsuitable Extinguishing Media: Do not use water directly on chemical; violent reaction possible
Specific Hazards: Releases hazardous hydrogen chloride and phosgene gas on combustion; reacts with water and alcohols
Personal Protective Equipment: Full protective gear including self-contained breathing apparatus
Firefighting Instructions: Approach fire from upwind, use fireproof protective clothing, avoid inhaling fumes, evacuate non-essential personnel
Explosion Hazards: Possible pressure buildup if heated in closed container; rupture risk
Personal Precautions: Evacuate area; avoid inhalation and contact with skin and eyes; ventilate area and use chemical splash goggles and gloves
Environmental Precautions: Keep out of sewers and waterways; notify authorities if significant spill occurs
Containment Methods: Absorb spill using dry, inert materials like sand, earth, or vermiculite; do not use water or sawdust
Cleanup Procedures: Collect waste in chemically resistant containers for proper disposal; decontaminate area with dilute sodium carbonate or lime solution; ventilate area for residual vapors
Emergency Procedures: Restrict access to site, contain spill from spreading, use only trained personnel with proper PPE
Handling: Wear chemical-resistant gloves, safety goggles, and lab coat; handle under fume hood with local exhaust; do not breathe vapors or allow contact with skin or eyes
Storage: Keep container tightly closed in a cool, dry, well-ventilated area away from incompatible substances such as water, alcohols, strong bases, amines, and oxidizers
Incompatibilities: Moist air, water, alcohols, amines, strong bases, oxidizing agents
Protective Measures: Inspect containers regularly for leaks or deterioration; keep away from open flames or sources of ignition
Other Storage Information: Store in containers lined with corrosion-resistant material; segregate from food or animal feed
Exposure Limits: No OSHA PEL established; exposure should be minimized
Engineering Controls: Chemical fume hood required; use local exhaust ventilation to minimize exposure
Personal Protective Equipment: Use chemical-resistant gloves (neoprene, nitrile), splash goggles, face shield, flame-resistant lab coat, full-length pants, closed-toe shoes
Respiratory Protection: Approved respirator if ventilation is inadequate or during spill cleanup
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke in the work area
Environmental Controls: Keep handling areas away from drains and surface water; ensure spill kits are readily available
Appearance: Clear to slightly yellow, fuming liquid
Odor: Pungent, irritating, suffocating, acrid smell
Odor Threshold: Not available
pH: Not applicable (hydrolyzes in water to HCl)
Melting Point: -110°C
Boiling Point: 90°C at 760 mmHg
Flash Point: Not applicable (does not flash easily due to corrosive nature)
Evaporation Rate: Not available
Flammability: Not classified as flammable, but can support combustion
Upper/Lower Explosion Limits: Not determined
Vapor Pressure: 26 mmHg at 25°C
Vapor Density: 3.67 (air = 1)
Solubility: Decomposes violently in water
Partition Coefficient (log Kow): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions, but extremely reactive with moisture, water, and alcohols
Reactivity: Vigorous reaction with water, strong bases, oxidizers, and amines producing heat and corrosive fumes
Hazardous Reactions: Hydrolyzes rapidly to hydrochloric acid and isobutyric acid
Conditions to Avoid: Exposure to air, humidity, heat, flames, incompatible chemicals
Incompatible Materials: Water, air, alkalis, alcohols, amines, oxidizers
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon oxides
Acute Toxicity: Inhalation and skin exposure can rapidly cause pain, burns, breathing difficulty, or systemic effects; LD50 (oral, rat): not adequately established due to corrosive effects; corrosive properties can mask classic toxicity symptoms
Skin Corrosion: Causes severe burns, blistering, and ulceration
Eye Damage: May cause irreversible eye damage or blindness
Respiratory Sensitization: Severe irritation, coughing, choking, pulmonary edema
Chronic Effects: Prolonged exposure may lead to dermatitis, bronchial irritation, lung damage
Carcinogenicity/Mutagenicity: Not classified as carcinogenic; not tested extensively for mutagenic potential
Other Data: Vapor contact can cause severe respiratory tract burns
Ecotoxicity: Highly toxic to aquatic life due to rapid acidification and corrosive effects
Persistence and Degradability: Hydrolyzes rapidly in water to isobutyric acid and hydrochloric acid, both of which can lower pH of soils and water
Bioaccumulative Potential: Expected to have low potential for bioaccumulation due to rapid hydrolysis and volatility
Mobility in Soil: High due to water reactivity, but decomposition products can leach into groundwater
Other Adverse Effects: Large spills may severely alter aquatic environments by drastically changing pH and causing fish kills
Disposal Methods: Dispose of by incineration in a licensed facility with afterburner and scrubber for hydrogen chloride removal; must neutralize with sodium carbonate or lime before discharge
Contaminated Packaging: Rinse with dilute alkaline solution before disposal; destroy containers or return for proper disposal
Regulatory Requirements: Chemical waste must be managed in accordance with local, regional, and national environmental and hazardous waste regulations; generators have responsibility for proper disposal
Precautions: Do not release into environment; avoid landfill disposal without treatment
UN Number: 2225
UN Proper Shipping Name: Isobutyryl Chloride
Transport Hazard Class: 8 (Corrosive), secondary risk for toxic fumes
Packing Group: II (medium hazard)
Marine Pollutant Status: Not a marine pollutant as per IMDG but harmful to aquatic environments
Special Precautions: Use corrosion-resistant, airtight packaging; label containers with hazard statements and pictograms; avoid damage to containers during transport
Emergency Response Guide Number: 157
Regulated by: ADR/RID, IMDG, IATA, and national transport authorities
OSHA Status: Hazardous chemical; listed as corrosive and acutely toxic
TSCA Inventory: Listed as a valid chemical substance
SARA Title III: Subject to SARA 313 reporting for hazardous chemicals
Right-to-Know Act: Listed in state and federal regulations where applicable; users must inform workers about hazards
Label Requirements: Proper labeling with hazard pictograms, signal word, and precautionary statements required by GHS and OSHA
International: Covered under REACH and CLP regulations in the EU
Additional Notes: Compliance essential for chemical storage, transport, and worker protection
