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Product Name: Isobutyric Anhydride
Chemical Formula: C8H14O3
CAS Number: 97-32-5
Synonyms: Isobutyric acid anhydride, 2,2-Dimethylpropanoic anhydride
Use: Industrial chemical; mordant in dyeing; pharmaceutical synthesis; acylation reagent
Manufacturer: Data provided by relevant supplier on shipping documents; specific emergency contacts listed on product packaging
Contact Information: Phone numbers for immediate chemical emergency and non-emergency information typically provided on original container label by legal supplier.
Recommended Restrictions: Avoid consumer use; for trained personnel in industrial settings only.
Hazard Classification: Flammable liquid (Category 3), Skin corrosion/irritation (Category 1B), Serious eye damage (Category 1), Specific target organ toxicity – single exposure (Category 3)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; may cause respiratory irritation; flammable liquid and vapor
Pictograms: Flame, corrosion, exclamation mark
Precautionary Statements: Avoid breathing vapors; keep away from ignition sources; wear protective gloves, goggles, and clothing; ensure good ventilation; wash skin thoroughly after handling; immediately flush eyes if exposed.
Emergency Overview: Releases pungent, acrid vapors; contact with moisture produces isobutyric acid causing severe irritation and possible tissue damage.
Chemical Name: Isobutyric Anhydride
Chemical Formula: (CH3)2CHCO2COCH(CH3)2
CAS Number: 97-32-5
Concentration: ≥98% by weight in commercial product
Impurities: Low levels of isobutyric acid as hydrolysis by-product; potential small amounts of related anhydrides depending on batch.
Stabilizers/Preservatives: Not intentionally added; check specific batch certificate for presence.
Inhalation: Remove affected person to fresh air immediately; keep individual at rest and comfortable; seek prompt medical attention if respiratory symptoms develop or worsen.
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water for at least fifteen minutes; if irritation persists or chemical burns develop, contact a physician.
Eye Contact: Immediately flush eyes with copious amounts of water for at least fifteen minutes, lifting eyelids intermittently; seek emergency medical attention as eye damage may be irreversible.
Ingestion: Do not induce vomiting; rinse mouth with water; give nothing by mouth if unconscious; seek medical help swiftly.
General Advice: Always provide medical staff with information on the chemical involved and the MSDS.
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, or alcohol-resistant foam; avoid using water as it can release heat and corrosive vapors.
Specific Hazards: Vapors form explosive mixtures with air; combustion produces acrid smoke, carbon oxides, and isobutyric acid fumes.
Protective Equipment: Firefighters require full protective gear, including self-contained breathing apparatus.
Precautions: Cool fire-exposed containers with water spray from a distance to prevent rupture; avoid runoff entering waterways.
Personal Precautions: Evacuate area; ensure adequate ventilation; use appropriate respiratory protection and chemical-resistant clothing.
Environmental Precautions: Prevent spills from entering sewers, watercourses, or low areas; notify authorities if environmental contamination is a risk.
Containment: Dike spills with inert barriers such as earth or sand; contain leaks quickly.
Cleanup Procedures: Absorb with inert material such as vermiculite or dry sand; collect in secure chemical waste containers; neutralize residues with diluted alkaline solution; decontaminate area thoroughly.
Handling: Handle only in well-ventilated environments; avoid direct contact with skin, eyes, and clothing; use non-sparking tools and explosion-proof equipment; ground containers; avoid generating vapors and aerosols.
Storage: Store in tightly closed, properly labeled containers made of compatible materials; keep away from heat or direct sunlight; segregate from moisture, strong oxidizers, bases, and acids.
Special Instructions: Regularly inspect storage area for leaks; use secondary containment for drums and bulk tanks; always have emergency shower and eye wash stations nearby.
Incompatible Materials: Water, alcohols, amines, strong bases, oxidizing agents.
Occupational Exposure Limits: No specific OSHA PEL; ACGIH TLV not available for isobutyric anhydride.
Engineering Controls: Use laboratory hoods or process enclosures; provide local exhaust ventilation if vapor concentrations exceed safety guidelines.
Personal Protective Equipment: Chemical splash goggles; face shield; chemical-resistant gloves (nitrile or neoprene recommended); flame-resistant laboratory coat; respirators conforming to NIOSH standards for organic vapor protection when airborne concentrations risk exists.
Hygiene Measures: Wash hands and exposed skin with soap and water before eating, drinking, or smoking; remove contaminated clothing and clean before reuse.
Emergency Equipment: Provide eyewash stations and safety showers at all points of use.
Appearance: Clear, colorless to light yellow liquid
Odor: Pungent, sharp, butter-like acid smell
Odor Threshold: Not determined
pH: Not applicable (anhydride hydrolyzes in water)
Melting Point/Freezing Point: -48°C
Boiling Point: 151°C (steam may carry vapors)
Flash Point: 43°C (closed cup method)
Evaporation Rate: Data not established
Flammability: Flammable liquid and vapor
Upper/Lower Flammability Limits: Lower explosive limit about 1.1%, upper limit not determined
Vapor Pressure: 2 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 0.935 at 20°C
Solubility: Reacts slowly with water; soluble in organic solvents such as ether, chloroform
Partition Coefficient (log Kow): Not established
Autoignition Temperature: Approximately 227°C
Decomposition Temperature: Not specified; decomposes in contact with moisture
Viscosity: Not determined or reported
Chemical Stability: Stable under recommended storage conditions; sensitive to moisture
Possibility of Hazardous Reactions: Violent reaction with water, alcohols, oxides, and bases generating heat and corrosive vapors
Conditions to Avoid: Exposing to humidity, direct flame, sparks, or elevated temperatures
Incompatible Materials: Water, strong oxidizing agents, bases, alcohols, amines
Hazardous Decomposition Products: Isobutyric acid, carbon monoxide, carbon dioxide, irritating organic vapors
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Causes severe irritation and burns to eyes, skin, and respiratory tract; inhaling vapors may result in coughing, chest tightness, and airway edema; ingestion produces burning and systemic toxicity
LD50 (oral, rat): 500 mg/kg (literature values, verify with supplier for batch specific data)
LD50 (dermal, rabbit): Not specified; expected to be corrosive
Chronic Effects: Prolonged or repeated exposure can result in dermatitis or delayed lung changes due to inhaled vapors; no established evidence for mutagenicity, carcinogenicity, or reproductive toxicity from published animal studies
Sensitization: No data documenting allergic responses; corrosive action may mask sensitization in practice
Ecotoxicity: Moderately toxic to aquatic life, especially due to rapid hydrolysis to isobutyric acid in water, causing lowered local pH
Persistence and Degradability: Anhydride rapidly reacts with water, forming biodegradable acid
Bioaccumulation: Not expected in aquatic or terrestrial systems owing to acid hydrolysis
Mobility in Soil: Liquid may migrate but will hydrolyze and bind to soil particles
Other Effects: Sudden large releases may result in severe fish kills and ecosystem pH shifts; regulatory notification may be required for major environmental releases.
Waste Treatment Methods: Dispose as hazardous chemical waste via licensed transporter; neutralize cautiously with dilute alkali before sewering subject to local regulations
Hazardous Waste Number: Contact local agency or consult regulatory lists for exact disposal code
Contaminated Packaging: Empty containers can retain residues; triple rinse and offer to licensed waste handling companies
Precautions: Do not dispose of into surface water, sewer, or non-approved landfills; track large volume or recurring disposal through manifest system
Regulatory Notifications: Alert authorized regulatory body if released in environmentally significant quantities.
UN Number: UN 2733
Shipping Name: Isobutyric anhydride
Transport Risk Class: 8 (Corrosive), subsidiary risk: 3 (Flammable liquid)
Packing Group: II
Transport Labels: Corrosive, Flammable Liquid
Marine Pollutant: Not designated, but spill control required near water
Special Precautions: Secure containers upright; segregate from incompatible freight; carry emergency response guide accessible to crew
Regulations: Comply with DOT, ADR, IMDG, IATA guidelines for chemicals in corrosive/flammable classes.
Labeling: Requires GHS-compliant pictograms, precautionary and hazard statements, and supplier information
US EPA: Listed on TSCA Inventory; requires reporting under section 313 if specific thresholds met
REACH Status (EU): Registration and notification under REACH; safety data available on ECHA portal
Canadian WHMIS: Classified as D1B (toxic), E (corrosive); product label and training required
Other International: Compliance with Japanese CSCL/PRTR and Australian AICS listing confirmed in supplier certification
Local Regulations: Local workplace exposure, use, and disposal limits may apply; always reference latest government publications for national updates.
