© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Isobutyl Isocyanate
CAS Number: 542-58-5
Synonyms: 2-Isocyanatobutane, Isocyanic acid, isobutyl ester
Recommended Uses: Chemical intermediate, laboratory reagent
Supplier Details: Name and address of manufacturer, supplier contact information including phone number for emergencies
Emergency Phone Number: CHEMTREC or company-designated hotline
Classification: Flammable liquid, Acute toxicity (inhalation, oral, dermal), Skin and eye irritant, Sensitizer (skin and respiratory)
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor, Toxic if inhaled or swallowed, Causes severe skin burns and eye damage, May cause allergic reactions upon contact or inhalation
Pictograms: Flame, Skull and Crossbones, Corrosion, Health Hazard
Precautionary Statements: Keep away from heat sources, Do not breathe vapor or mist, Wear protective gear, Wash thoroughly after handling, Use only in well-ventilated areas
Chemical Name: Isobutyl Isocyanate
CAS Number: 542-58-5
Concentration: 98-100%
Impurities: Trace isocyanates, possibly minor hydrolysis byproducts
Other Components: No hazardous non-isocyanate ingredients present
Inhalation: Move person to fresh air, keep at rest, call poison center or doctor, provide oxygen if breathing is difficult, do not give anything by mouth if unconscious
Skin Contact: Remove contaminated clothing and rinse skin with water for at least 15 minutes, seek medical attention promptly
Eye Contact: Flush eyes with water for at least 15 minutes holding eyelids open, remove contact lenses if present and easy to do, call physician immediately
Ingestion: Rinse mouth, do not induce vomiting, call poison center or get emergency medical help immediately
Most Important Symptoms: Respiratory distress, burns, eye damage, skin sensitization, delayed onset possible
Suitable Extinguishing Media: Carbon dioxide, foam, dry chemical, avoid water jets which may spread material
Specific Hazards: Produces toxic gases including nitrogen oxides, hydrogen cyanide, carbon monoxide on burning, vapors may form explosive mixtures in air
Special Protective Equipment: Full turnout gear, self-contained breathing apparatus, chemical splash suit
Advice for Firefighters: Cool containers exposed to flames, stay upwind, prevent runoff to drains or water bodies
Personal Precautions: Evacuate non-essential personnel, ventilate area, wear appropriate chemical-resistant gloves, eye and face protection, respirator if needed
Environmental Precautions: Prevent entry into sewers, surface water, or soil, contain spills using inert absorbent material
Cleanup Methods: Absorb with sand or vermiculite, collect residue in chemical waste drum, wash down with dilute ammonia or hypochlorite solution, ventilate thoroughly before re-entry
Disposal: Follow federal and local regulations, avoid direct handling of contaminated materials
Safe Handling: Use only in chemical fume hood, ground and bond containers, avoid contact with moisture and oxidizers, do not eat, drink or smoke near material
Storage Conditions: Store in cool, well-ventilated area away from heat and ignition, tightly sealed metal container only, segregated from acids, bases, and amines
Incompatible Materials: Strong oxidizers, water, alcohols, amines, acids, bases
Specific Practices: Clearly label all containers, practice strict chemical hygiene, monitor for leaks or corrosion
Exposure Limits: ACGIH TLV: 0.005 ppm (ceiling), OSHA PEL: none established
Engineering Controls: Local exhaust ventilation, explosion-proof equipment
Personal Protective Equipment: Chemical goggles, face shield, flame-resistant lab coat, chemical-resistant gloves (nitrile, neoprene), organic vapor respirator
Hygiene Measures: Wash hands after handling, remove contaminated clothing immediately, do not reuse until washed
Appearance: Clear, colorless to pale yellow liquid
Odor: Sharp, pungent isocyanate odor
Molecular Formula: C5H9NO
Molecular Weight: 99.13 g/mol
Boiling Point: 120-123 °C
Melting Point: -76 °C
Flash Point: 24 °C (closed cup)
Vapor Density: 3.4 (air = 1)
Vapor Pressure: 7 mm Hg at 20 °C
Solubility: Reacts with water, slightly soluble in most organic solvents
Chemical Stability: Unstable in presence of moisture, heat or sunlight
Reactivity: Violent reaction with water, acids, bases, alcohols and amines forming CO2 and toxic vapors
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen cyanide
Polymerization: May occur in contact with water or amines, risk of pressure buildup and container rupture
Acute Toxicity: LD50 oral (rat): 71 mg/kg, LD50 dermal (rabbit): 95 mg/kg, LC50 inhalation (rat): 0.09 mg/l/4h
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Effects: Severe respiratory irritation, pulmonary edema, skin and eye burns, systemic toxicity, sensitization after repeated exposure
Delayed/Chronic Effects: Asthma, dermatitis, possible organ damage from repeated exposure
Carcinogenicity: Not classified by IARC, NTP, or OSHA
Toxicity to Aquatic Life: Harmful to aquatic organisms, risk of acute effects in fish and daphnia
Persistence: Rapidly hydrolyzes in water to produce insoluble polyureas and CO2
Bioaccumulation: Low potential for bioaccumulation
Mobility: Volatile, vapor-phase transport is significant
Degradation: Hydrolyzes rapidly to less harmful substances when in contact with moisture
Waste Handling: Incinerate in approved facility with afterburner and scrubber for acid gases, do not dispose in landfill
Container Disposal: Empty containers contain residue, triple rinse and puncture before disposal, follow local disposal rules
Precautions: Do not allow material or runoff to reach surface waters or sewers, consult environmental agency for appropriate procedures
UN Number: UN2480
Proper Shipping Name: Isobutyl Isocyanate
Hazard Class: 6.1 (Toxic substances)
Packing Group: I
Labeling Requirements: Toxic, flammable liquid
Transport by Road/Rail (ADR/RID): Comply with international carriage of dangerous goods
Marine Transport (IMDG): IMDG Code compliant, emergency schedules for spills and fires
Air Transport (IATA): Refer to packing instructions and operator notifications
OSHA: Hazardous chemical by definition of Hazard Communication Standard
TSCA Inventory: Listed
SARA Title III: Section 302 Extremely Hazardous Substance, Section 313 Toxic Release
California Proposition 65: Not listed as known to cause cancer or reproductive toxicity
Other Standards: Follow workplace and environmental control standards, ensure employee training and reporting as required by federal, state, and local regulations
